Impaired G‐proteins and cyclic nucleotide phosphodiesterase activity in T‐lymphocytes from patients with sarcoidosis

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

The Glomerular Permeability Determined by Dextran Clearance Using Sephadex Gel Filtration

1968 • 2,659 citations

Pulmonary sarcoidosis

2018 • 894 citations

The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding.

1982 • 542 citations

The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response

1988 • 533 citations

G Proteins in Signal Transduction

1990 • 479 citations

Gamma interferon is spontaneously released by alveolar macrophages and lung T lymphocytes in patients with pulmonary sarcoidosis.

1985 • 462 citations

Enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromide

1975 • 417 citations

Signal transduction by guanine nucleotide binding proteins

1987 • 362 citations

Spontaneous Release of Interleukin-2 by Lung T Lymphocytes in Active Pulmonary Sarcoidosis

1983 • 358 citations

Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium.

1986 • 202 citations

[30] Assay of cyclic nucleotide phosphodiesterases with radioactive substrates

1974 • 184 citations

Transmembrane Ion Fluxes during Activation of Human T Lymphocytes: Role of Ca²⁺, Na⁺/H⁺ Exchange and Phospholipid Turnover

1987 • 154 citations

Multiple high-affinity cAMP-phosphodiesterases in human T-lymphocytes

1991 • 130 citations

Compartmentalized activation of the interleukin 2 gene by lung T lymphocytes in active pulmonary sarcoidosis.

1986 • 116 citations

cAMP antagonizes interleukin 2-promoted T-cell cycle progression at a discrete point in early G1.

1988 • 97 citations

An Immunodeficiency Characterized by Defective Signal Transduction in T Lymphocytes

1989 • 88 citations

Calcium, cyclic AMP and protein kinase C ? partners in mitogenesis

1987 • 86 citations

Stimulation of specific GTP binding and hydrolysis activities in lymphocyte membrane by interleukin-2

1987 • 83 citations

Control of human T-lymphocyte interleukin-2 production by a cAMP-dependent pathway

1988 • 70 citations

Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4).

1990 • 68 citations

Evidence of cells bearing interleukin-2 receptor at sites of disease activity in sarcoid patients.

1984 • 67 citations

Signal transduction pathway for IL-1. Involvement of a pertussis toxin-sensitive GTP-binding protein in the activation of adenylate cyclase.

1989 • 65 citations

Interleukin-2 Receptor Gene Expression by Bronchoalveolar Lavage Lymphocytes in Pulmonary Sarcoidosis

1989 • 51 citations

Inhibition and activation of interleukin 2 synthesis by direct modification of guanosine triphosphate-binding proteins.

1988 • 43 citations

Antigen-induced Proliferative Response of Lavage and Blood T Lymphocytes: Comparison of Cells from Normal Subjects and Patients with Sarcoidosis

1991 • 36 citations

Flow cytometry analysis of T lymphocytes in sarcoidosis

1982 • 32 citations

The effects of pertussis toxin and cholera toxin on mitogen-induced interleukin-2 production: Evidence for G protein involvement in signal transduction

1988 • 26 citations

Evidence that guanine-nucleotide binding regulatory proteins couple cell-surface receptors to the breakdown of inositol-containing lipids during T-lymphocyte mitogenesis

1987 • 24 citations

Functional maturation of human T lymphocytes is accompanied by changes in the G-protein pattern.

1990 • 18 citations

Influence of dietary omega-3 fatty acids on transmembrane signalling in rat submandibular salivary gland

1990 • 18 citations

Cyclic adenosine 3',5'-monophosphate metabolism in activated T-cell clones.

1989 • 16 citations

Isoelectric-focusing patterns of cyclic nucleotide phosphodiesterase from rat heart

1981 • 16 citations

CD3/T‐cell receptor coupling to a pertussis and cholera toxin‐insensitive G‐protein

1989 • 13 citations

Interrelationship between signals transduced by phytohemagglutinin and interleukin 1

1990 • 13 citations

Metabolism of αβ-diaminopropionate in a Pseudomonas sp

1970 • 10 citations

Alveolar Lymphocytes from Patients with Sarcoidosis Respond Poorly to Activation by Mitogenic Lectins

1986 • 8 citations

Phosphatidyl inositol hydrolysis after CD3 binding in human peripheral blood T cells: Inhibition by prostaglandin E2

1989 • 7 citations

Distribution of the α-subunit of the Guanine Nucleotide-binding Protein G_i2and its Comparison to Gα_o

1989 • 7 citations

Phosphatidylethanolamine methyltransferase and cAMP, cGMP phosphodiesterases in lymphocytes and monocytes in sarcoidosis

1987 • 5 citations

Decreased Cyclic Nucleotide Phosphodiesterase Activity in Human Peripheral Blood Mononuclear Cells from Elderly Women

1990 • 5 citations

Dilsulfide‐linked receptors for mitogenic lectins on piglet lymphocytes

1988 • 4 citations

Impaired production of interleukin-2 in peripheral blood of patients with sarcoidosis.

1985 • 4 citations

Concanavalin A receptor-associated GTP-binding proteins

1990 • 3 citations