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Integrin targeted oncolytic adenoviruses Ad5‐D24‐RGD and Ad5‐RGD‐D24‐GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors

Data up to Jan 2025

Published2011
Citations96
References47

Total Citations Per Year

Abstract

References (47)

Dendritic cells and the control of immunity

1998 • 14,345 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

2003 • 1,418 citations

Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

2005 • 878 citations

An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism via Utilization of a Coxsackievirus and Adenovirus Receptor-Independent Cell Entry Mechanism

1998 • 764 citations

A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo

2000 • 742 citations

Phase II Clinical Trial of a Granulocyte-Macrophage Colony-Stimulating Factor–Encoding, Second-Generation Oncolytic Herpesvirus in Patients With Unresectable Metastatic Melanoma

2009 • 584 citations

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

2000 • 572 citations

A Phase I Study of OncoVEXGM-CSF, a Second-Generation Oncolytic Herpes Simplex Virus Expressing Granulocyte Macrophage Colony-Stimulating Factor

2006 • 541 citations

Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial

2008 • 499 citations

A randomized placebo-controlled phase III study of granulocyte- macrophage colony-stimulating factor in adult patients (> 55 to 70 years of age) with acute myelogenous leukemia: a study of the Eastern Cooperative Oncology Group (E1490)

1995 • 462 citations

Regulation of myeloid development and function by colony stimulating factors

2003 • 385 citations

Treatment of Cancer Patients With a Serotype 5/3 Chimeric Oncolytic Adenovirus Expressing GMCSF

2010 • 225 citations

Use of recombinant granulocyte-macrophage colony-stimulating factor during and after remission induction chemotherapy in patients aged 61 years and older with acute myeloid leukemia (AML): final report of AML-11, a phase III randomized study of the Leukemia Cooperative Group of European Organisation for the research and treatment of cancer (EORTC-LCG) and the Dutch Belgian Hemato-Oncology Cooperative Group (HOVON)

1997 • 217 citations

Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients

2010 • 213 citations

Evidence that granulocyte macrophage-colony-stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers.

1993 • 198 citations

Phase I–II trial of ONYX-015 in combination with MAP chemotherapy in patients with advanced sarcomas

2005 • 168 citations

Expression of HLA-A,B,C antigens on primary and metastatic tumor cell populations of human carcinomas.

1991 • 160 citations

Treatment of ovarian cancer with a tropism modified oncolytic adenovirus.

2002 • 156 citations

Cyclophosphamide Augments Antitumor Immunity: Studies in an Autochthonous Prostate Cancer Model

2009 • 153 citations

Treatment of metastatic neuroblastoma with systemic oncolytic virotherapy delivered by autologous mesenchymal stem cells: an exploratory study

2010 • 131 citations

Low-dose Cyclophosphamide Treatment Impairs Regulatory T Cells and Unmasks AFP-specific CD4+ T-cell Responses in Patients With Advanced HCC

2010 • 122 citations

Current Developments In Adenovirus-Based Cancer Gene Therapy

2006 • 115 citations

Comparison of One-, Two-, and Three-Dimensional Measurements of Childhood Brain Tumors

2001 • 110 citations

Frequency, demographics and risk (according to tumour type or site) of cancer-associated thrombosis among patients seen at outpatient DVT clinics

2009 • 92 citations

A phase I trial of intravenous infusion of ONYX-015 and enbrel in solid tumor patients

2007 • 84 citations

Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 (‘Telomelysin-RGD’)

2005 • 84 citations

A phase I study of KH901, a conditionally replicating granulocyte-macrophage colony-stimulating factor: Armed oncolytic adenovirus for the treatment of head and neck cancers

2009 • 83 citations

Prolonged systemic circulation of chimeric oncolytic adenovirus Ad5/3-Cox2L-D24 in patients with metastatic and refractory solid tumors

2010 • 70 citations

Adenovirus hexon T-cell epitope is recognized by most adults and is restricted by HLA DP4, the most common class II allele

2004 • 64 citations

Intralesional Cytokine Therapy in Cancer

1998 • 55 citations

In situ adenovirus vaccination engages T effector cells against cancer

2009 • 53 citations

A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma

2004 • 50 citations

Activation of Tumor-Specific CD8+ T Cells after Intratumoral Ad5-TRAIL/CpG Oligodeoxynucleotide Combination Therapy

2007 • 47 citations

Evaluation of a selectively oncolytic adenovirus for local and systemic treatment of cervical cancer

2004 • 43 citations

A modified E2F-1 promoter improves the efficacy to toxicity ratio of oncolytic adenoviruses

2009 • 43 citations

Systemic efficacy of oncolytic adenoviruses in imagable orthotopic models of hormone refractory metastatic breast cancer

2007 • 43 citations

Regulatory T cell depletion enhances tumor specific CD8 T-cell responses, elicited by tumor antigen NY-ESO-1b in hepatocellular carcinoma patients, in vitro

2010 • 42 citations

Identifying the safety profile of a novel infectivity-enhanced conditionally replicative adenovirus, Ad5-Δ24-RGD, in anticipation of a phase I trial for recurrent ovarian cancer

2007 • 40 citations

Intralesional granulocyte‐monocyte colony‐stimulating factor followed by subcutaneous interleukin‐2 in metastatic melanoma: a pilot study in elderly patients

2001 • 40 citations

Noninvasive imaging for evaluation of the systemic delivery of capsid‐modified adenoviruses in an orthotopic model of advanced lung cancer

2006 • 39 citations

Survivin promoter-based conditionally replicative adenoviruses target cholangiocarcinoma

2006 • 38 citations

Oncolytic adenovirus treatment of a patient with refractory neuroblastoma

2010 • 35 citations

Stimulation of suppressor cells in the bone marrow and spleens of high dose cyclophosphamide-treated C57Bl/6 mice

1987 • 29 citations

Live viruses in cancer treatment.

2002 • 27 citations

E1A, E1B Double-Restricted Adenovirus with RGD-Fiber Modification Exhibits Enhanced Oncolysis for CAR–Deficient Biliary Cancers

2007 • 24 citations

Linked Tumor-Selective Virus Replication and Transgene Expression from E3-Containing Oncolytic Adenoviruses

2005 • 19 citations

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Integrin targeted oncolytic adenoviruses Ad5‐D24‐RGD and Ad5‐RGD‐D24‐GMCSF for treatment… (2011) – International Journal of Cancer | Metascience Observatory Explorer