The evolution of tamoxifen therapy in breast cancer: selective oestrogen-receptor modulators and downregulators
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References (88)
Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
1998 • 5,487 citations
Cloning of a novel receptor expressed in rat prostate and ovary.
1996 • 4,782 citations
Tamoxifen for early breast cancer: an overview of the randomised trials
1998 • 4,082 citations
Molecular basis of agonism and antagonism in the oestrogen receptor
1997 • 3,285 citations
The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen
1998 • 2,622 citations
Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy
1992 • 2,084 citations
The Effect of Raloxifene on Risk of Breast Cancer in Postmenopausal Women
1999 • 1,858 citations
Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites
1997 • 1,808 citations
Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription
2000 • 1,658 citations
Effects of Raloxifene on Bone Mineral Density, Serum Cholesterol Concentrations, and Uterine Endometrium in Postmenopausal Women
1997 • 1,641 citations
Tamoxifen in the Treatment of Breast Cancer
1998 • 1,295 citations
Effects of Tamoxifen on Bone Mineral Density in Postmenopausal Women with Breast Cancer
1992 • 1,139 citations
The Estrogen Receptor β-Isoform (ERβ) of the Human Estrogen Receptor Modulates ERα Transcriptional Activity and Is a Key Regulator of the Cellular Response to Estrogens and Antiestrogens1
1999 • 1,055 citations
Superior Efficacy of Letrozole Versus Tamoxifen as First-Line Therapy for Postmenopausal Women With Advanced Breast Cancer: Results of a Phase III Study of the International Letrozole Breast Cancer Group
2001 • 1,019 citations
Anastrozole Is Superior to Tamoxifen as First-Line Therapy for Advanced Breast Cancer in Postmenopausal Women: Results of a North American Multicenter Randomized Trial
2000 • 990 citations
ADJUVANT TAMOXIFEN IN EARLY BREAST CANCER: OCCURRENCE OF NEW PRIMARY CANCERS
1989 • 932 citations
The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture.
1976 • 820 citations
A New Anti-oestrogenic Agent in Late Breast Cancer: An Early Clinical Appraisal of ICI46474
1971 • 692 citations
Continued Breast Cancer Risk Reduction in Postmenopausal Women Treated with Raloxifene: 4-Year Results from the MORE Trial
2001 • 678 citations
Letrozole, a new oral aromatase inhibitor for advanced breast cancer: double-blind randomized trial showing a dose effect and improved efficacy and tolerability compared with megestrol acetate.
1998 • 647 citations
Five Versus More Than Five Years of Tamoxifen for Lymph Node-Negative Breast Cancer: Updated Findings From the National Surgical Adjuvant Breast and Bowel Project B-14 Randomized Trial
2001 • 634 citations
Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats.
1994 • 614 citations
After the Trial at Leicester
1981 • 545 citations
Exemestane Is Superior to Megestrol Acetate After Tamoxifen Failure in Postmenopausal Women With Advanced Breast Cancer: Results of a Phase III Randomized Double-Blind Trial
2000 • 531 citations
Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover.
1992 • 468 citations
A NEW DERIVATIVE OF TRIPHENYLETHYLENE: EFFECT ON IMPLANTATION AND MODE OF ACTION IN RATS
1967 • 456 citations
A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies.
2002 • 446 citations
Estrogen receptors and breast cancer response to adrenalectomy.
1971 • 434 citations
Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma: results of a survival update based on a combined analysis of data from two mature phase III trials. Arimidex Study Group.
1998 • 421 citations
Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse.
1988 • 420 citations
Development of antiestrogens and their use in breast cancer: eighth Cain memorial award lecture.
1990 • 419 citations
Effects of Tamoxifen on Cardiovascular Risk Factors in Postmenopausal Women
1991 • 380 citations
Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata
1976 • 377 citations
Anti-oestrogen Therapy for Breast Cancer: A Trial of Tamoxifen at Two Dose Levels
1973 • 373 citations
Prognostic significance of progesterone receptor levels in estrogen receptor-positive patients with metastatic breast cancer treated with tamoxifen: results of a prospective Southwest Oncology Group study.
1992 • 360 citations
Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer
1995 • 351 citations
Oral penicillin in gonorrhoea.
1946 • 348 citations
Adjuvant tamoxifen in the management of operable breast cancer : Scottish Trial
1987 • 344 citations
Structural Insights into the Mode of Action of a Pure Antiestrogen
2001 • 342 citations
Effects of anti-estrogens on bone in castrated and intact female rats
1987 • 329 citations
Activity of Exemestane in Metastatic Breast Cancer After Failure of Nonsteroidal Aromatase Inhibitors: A Phase II Trial
2000 • 318 citations
STEROIDAL PURE ANTIOESTROGENS
1987 • 313 citations
Aromatase Inhibitors in the Treatment and Prevention of Breast Cancer
2001 • 300 citations
Growth Regulation of Estrogen Receptor-Negative Breast Cancer Cells Transfected With Complementary DNAs for Estrogen Receptor
1992 • 263 citations
Inhibition of tamoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens.
1989 • 249 citations
STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTI-OESTROGENS WITH REGARD TO INTERACTION WITH 17β-OESTRADIOL IN THE MOUSE UTERUS AND VAGINA
1971 • 211 citations
The Mechanism of ICI 164,384 Antiestrogenieity Involves Rapid Loss of Estrogen Receptor in Uterine Tissue
1991 • 201 citations
Effects of Tamoxifen on Spinal Bone Density in Women With Breast Cancer
1989 • 197 citations
Tamoxifen (ICI 46,474) and the human carcinoma 8S oestrogen receptor
1975 • 186 citations
Phase II Evaluation of Lyl56758 in Metastatic Breast Cancer
1988 • 180 citations
Anastrozole versus megestrol acetate in the treatment of postmenopausal women with advanced breast carcinoma
1998 • 171 citations
EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometrium
1999 • 163 citations
Effects of Raloxifene on Bone Mineral Density, Serum Cholesterol Concentrations, and Uterine Endometrium in Postmenopausal Women
1998 • 162 citations
The estrogen receptor from a tamoxifen stimulated MCF-7 tumor variant contains a point mutation in the ligand binding domain
1994 • 152 citations
Selective estrogen receptor modulation: a personal perspective.
2001 • 151 citations
ADJUVANT TAMOXIFEN IN THE MANAGEMENT OF OPERABLE BREAST CANCER: THE SCOTTISH TRIAL
1987 • 145 citations
3-[4-(1,2-Diphenylbut-1-enyl)phenyl]acrylic Acid: A Non-Steroidal Estrogen with Functional Selectivity for Bone over Uterus in Rats
1994 • 144 citations
Species-specific pharmacology of antiestrogens: role of metabolism.
1987 • 131 citations
The development of tamoxifen for breast cancer therapy: A tribute to the late Arthur L. Walpole
1988 • 130 citations
LY353381.HCl: a novel raloxifene analog with improved SERM potency and efficacy in vivo.
1998 • 129 citations
Randomized trial of diethylstilbestrol vs. tamoxifen in postmenopausal women with metastatic breast cancer. An updated analysis
1999 • 128 citations
Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCa101) in athymic mice.
1990 • 127 citations
The Brighton resuscitation ambulances: a continuing experiment in prehospital care by ambulance staff.
1976 • 127 citations
The key to the antiestrogenic mechanism of raloxifene is amino acid 351 (aspartate) in the estrogen receptor.
1998 • 122 citations
New biospecific adsorbents for the purification of estradiol receptor.
1978 • 120 citations
Allosteric silencing of activating function 1 in the 4-hydroxytamoxifen estrogen receptor complex is induced by substituting glycine for aspartate at amino acid 351.
2000 • 110 citations
243. Antitumour activity of the antiestrogen ICI 46,474 (Tamoxifen) in the dimethylbenzanthracene (DMBA)—induced rat mammary carcinoma model
1974 • 107 citations
THE INDUCTION OF OVULATION BY TAMOXIFEN
1973 • 104 citations
Estrogenic activity is increased for an antiestrogen by a natural mutation of the estrogen receptor
1997 • 104 citations
Molecular Mechanism of Action at Estrogen Receptor α of a New Clinically Relevant Antiestrogen (GW7604) Related to Tamoxifen**This work was supported by NIH CA-56143 (to V.C.J.); Fundaçao Coordenaçao de Aperfeiçoamento de Pessoal de Nível Superior, (CAPES) Scholarship, Brazil (to R.D.); the U.S. Army Medical Research and Material Command Breast Cancer Research Program, DAMD17–96-16169 (to H.L.); the generosity of the Lynn Sage Breast Cancer Research Foundation of Northwestern Memorial …
2001 • 92 citations
A naturally occurring estrogen receptor mutation results in increased estrogenicity of a tamoxifen analog.
1995 • 82 citations
Silencing and reactivation of the selective estrogen receptor modulator-estrogen receptor alpha complex.
2001 • 73 citations
Phase I Study of a Third-Generation Selective Estrogen Receptor Modulator, LY353381.HCl, in Metastatic Breast Cancer
2001 • 72 citations
SYNTHETIC ŒSTROGENS IN MAMMARY CANCER
1949 • 69 citations
Inhibition of the Uterotropic Activity of Estrogens and Antiestrogens by the Short Acting Antiestrogen LY117018*
1983 • 66 citations
The oestrogen-like effect of 4-hydroxytamoxifen on induction of transforming growth factor alpha mRNA in MDA-MB-231 breast cancer cells stably expressing the oestrogen receptor
1998 • 65 citations
The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor.
1999 • 65 citations
OOPHORECTOMY IN CANCER OF THE BREAST
1902 • 62 citations
Prevention of bone loss by EM-800 and raloxifene in the ovariectomized rat
2000 • 59 citations
Possible mechanisms in the emergence of tamoxifen-resistant breast cancer
1995 • 55 citations
The ATAC (Arimidex, Tamoxifen, Alone or in Combination) adjuvant breast cancer trial in postmenopausal (PM) women.
2001 • 55 citations
Analysis of cross-resistance of the selective estrogen receptor modulators arzoxifene (LY353381) and LY117018 in tamoxifen-stimulated breast cancer xenografts.
2001 • 50 citations
Tamoxifen: a personal retrospective
2000 • 43 citations
Regulation of Prolactin Synthesis in Vitro by Estrogenic and Antiestrogenic Derivatives of Estradiol and Estrone*
1989 • 40 citations
A naturally occurring estrogen receptor mutation results in increased estrogenicity of a tamoxifen analog
1995 • 34 citations
Randomized comparison of tamoxifen versus diethylstilbestrol in estrogen receptor-positive or -unknown metastatic breast cancer: a Southeastern Cancer Study Group trial.
1986 • 29 citations
Structural derivatives of tamoxifen and oestradiol 3-methyl ether as potential alkylating antioestrogens
1981 • 20 citations
The ATAC ('Arimidex', tamoxifen, alone or in combination) adjuvant breast cancer trial in postmenopausal (PM) women
2002 • 11 citations