Clinical aspects of exhaled nitric oxide

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Increased nitric oxide in exhaled air of asthmatic patients

1994 • 1,462 citations

Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma.

1996 • 1,370 citations

Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

1995 • 1,366 citations

Increased amount of nitric oxide in exhaled air of asthmatics

1993 • 1,252 citations

Induction of nitric oxide synthase in asthma

1993 • 852 citations

Neutrophilic Inflammation in Severe Persistent Asthma

1999 • 850 citations

Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide in Adults and Children—1999

1999 • 751 citations

Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma.

1998 • 694 citations

Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients.

1996 • 588 citations

Nitric oxide and asthmatic inflammation

1995 • 514 citations

Marked flow-dependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide.

1997 • 482 citations

Lower Airway Inflammation in Infants and Young Children with Cystic Fibrosis

1997 • 470 citations

Increased formation of the potent oxidant peroxynitrite in the airways of asthmatic patients is associated with induction of nitric oxide synthase: effect of inhaled glucocorticoid

1998 • 441 citations

Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome

1994 • 403 citations

Expired nitric oxide levels during treatment of acute asthma.

1995 • 353 citations

Formation of 8‐nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination

1995 • 343 citations

Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide.

1995 • 329 citations

Effect of Cigarette Smoke Extract on Nitric Oxide Synthase in Pulmonary Artery Endothelial Cells

1998 • 324 citations

Effect of a nitric oxide synthase inhibitor and a glucocorticosteroid on exhaled nitric oxide.

1995 • 276 citations

Effect of inhaled steroids on airway hyperresponsiveness, sputum eosinophils, and exhaled nitric oxide levels in patients with asthma

1999 • 270 citations

Effect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma

1999 • 265 citations

Exhaled nitric oxide in paediatric asthma and cystic fibrosis.

1996 • 261 citations

NO in Exhaled Air of Asthmatic Children Is Reduced by the Leukotriene Receptor Antagonist Montelukast

1999 • 255 citations

Inducible nitric oxide synthase expression is reduced in cystic fibrosis murine and human airway epithelial cells.

1998 • 251 citations

Changes in the dose of inhaled steroid affect exhaled nitric oxide levels in asthmatic patients

1996 • 247 citations

Reduced upper airway nitric oxide in cystic fibrosis.

1996 • 246 citations

Effect of Inhaled Budesonide on Lung Function and Airway Inflammation

1999 • 237 citations

Exhaled Nitric Oxide Correlates with Airway Hyperresponsiveness in Steroid-naive Patients with Mild Asthma

1998 • 228 citations

Corticosteroids decrease exhaled nitric oxide in children with acute asthma

1997 • 226 citations

Exhaled and nasal NO levels in allergic rhinitis: relation to sensitization, pollen season and bronchial hyperresponsiveness

1999 • 212 citations

Decreased concentration of exhaled nitric oxide (NO) in patients with cystic fibrosis

1997 • 211 citations

Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects.

1996 • 191 citations

Time Course of Change in Bronchial Reactivity with an Inhaled Corticosteroid in Asthma

1991 • 184 citations

Lack of inducible nitric oxide synthase in bronchial epithelium: a possible mechanism of susceptibility to infection in cystic fibrosis

1998 • 178 citations

Airway nitric oxide in asthmatic children and patients with cystic fibrosis

1996 • 169 citations

Exhaled Nitric Oxide as a Noninvasive Assessment of Chronic Cough

1999 • 163 citations

Exhaled Nitric Oxide Concentrations during Treatment of Wheezing Exacerbation in Infants and Young Children

1999 • 158 citations

Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase.

1996 • 158 citations

Pulmonary dysfunction in cystic fibrosis is associated with oxidative stress

1996 • 149 citations

Evidence for Increased oxidative Damage in Patients with Cystic Fibrosis

1994 • 145 citations

A Dose-dependent Effect of the Novel Inhaled Corticosteroid Ciclesonide on Airway Responsiveness to Adenosine-5 ′ -Monophosphate in Asthmatic Patients

1999 • 144 citations

Pulmonary oxidative stress response in young children with cystic fibrosis

1997 • 140 citations

Relationship between Exhaled Nitric Oxide and Childhood Asthma

1998 • 135 citations

Exhaled nitric oxide is not elevated in the inflammatory airways diseases of cystic fibrosis and bronchiectasis

1998 • 124 citations

Smoking Cessation Is Associated With an Increase in Exhaled Nitric Oxide

1997 • 121 citations

Effect of Natural Grass Pollen Exposure on Exhaled Nitric Oxide in Asthmatic Children

1999 • 118 citations

Changes in sputum composition between two inductions performed on consecutive days.

1998 • 116 citations

Fractional analysis of sequential induced sputum samples during sputum induction: Evidence that different lung compartments are sampled at different time points☆☆☆

1999 • 111 citations

Exhaled Nitric Oxide Is Increased in Active Fibrosing Alveolitis

1999 • 104 citations

Exhaled nitric oxide before and after montelukast sodium therapy in school-age children with chronic asthma: A preliminary study

1999 • 103 citations

Eosinophils transcribe and translate messenger RNA for inducible nitric oxide synthase.

1997 • 102 citations

Exhaled Nitric Oxide and Bronchial Reactivity During and After Inhaled Beclomethasone in Mild Asthma

1998 • 101 citations

Total Sputum Nitrate plus Nitrite Is Raised during Acute Pulmonary Infection in Cystic Fibrosis

1998 • 101 citations

Methods for sputum induction and analysis of induced sputum: a method for assessing airway inflammation in asthma.

1998 • 99 citations

Exhaled Nitric Oxide, Sensitization, and Exposure to Allergens in Patients with Asthma Who Are Not Taking Inhaled Steroids

1999 • 98 citations

Induced Sputum, Eosinophilic Bronchitis, and Chronic Obstructive Pulmonary Disease

1999 • 98 citations

Nitric Oxide Inhalation During Exercise in Chronic Obstructive Pulmonary Disease

1997 • 97 citations

Changes in sputum composition during sputum induction in healthy and asthmatic subjects

1998 • 96 citations

An inhaled steroid improves markers of airway inflammation in patients with mild asthma

1998 • 95 citations

Nitric Oxide Is Present in Exhaled Breath in Humans: Direct GC-MS Confirmation

1994 • 94 citations

Decreased exhaled nitric oxide may be a marker of cardiopulmonary bypass–induced injury

1998 • 81 citations

Exhaled and nasal nitric oxide measurements : recommendations

1997 • 80 citations

Neutrophil-derived long-lived oxidants in cystic fibrosis sputum.

1995 • 79 citations

Exhaled Nitric Oxide During Exercise in Primary Pulmonary Hypertension and Pulmonary Fibrosis

1997 • 75 citations

Administration of budesonide once daily by means of Turbuhaler to subjects with stable asthma☆☆☆★

1999 • 73 citations

Allergen avoidance is associated with a fall in exhaled nitric oxide in asthmatic children☆☆☆★

1999 • 71 citations

Exhaled nitric oxide during acute changes of airways calibre in asthma

1996 • 70 citations

Exhaled Nitric Oxide Does Not Provide a Marker of Vascular Endothelial Function in Healthy Humans

1999 • 69 citations

Childhood asthma: exhaled nitric oxide in relation to clinical symptoms

1999 • 59 citations

Exhaled and nasal nitric oxide is increased in laboratory animal allergy

1998 • 58 citations

IMMUNOHISTOCHEMICAL LOCALIZATION OF NITRIC OXIDE SYNTHASE AND THE OXIDANT PEROXYNITRITE IN LUNG TRANSPLANT RECIPIENTS WITH OBLITERATIVE BRONCHIOLITIS1

1997 • 53 citations

eNOS expression is not altered in pulmonary vascular remodeling due to increased pulmonary blood flow

1998 • 50 citations

Effect of salmeterol treatment on nitric oxide level in exhaled air and dose–response to terbutaline in children with mild asthma

1998 • 48 citations

In Stable Lung Transplant Recipients, Exhaled Nitric Oxide Levels Positively Correlate with Airway Neutrophilia and Bronchial Epithelial iNOS

1999 • 46 citations

Endothelial nitric oxide synthase in hypoxic newborn porcine pulmonary vessels

1997 • 41 citations

Expression of inducible nitric oxide synthase and formation of peroxynitrite in posttransplant obliterative bronchiolitis.

1998 • 34 citations

Exhaled Nitric Oxide and Bronchoalveolar Lavage Nitrite/Nitrate in Active Pulmonary Sarcoidosis

1997 • 32 citations

Nitric oxide-mediated regulation of transepithelial sodium and chloride transport in murine nasal epithelium

1999 • 31 citations

Nasal nitric oxide and its relationship to nasal symptoms, smoking and nasal nitrate.

1998 • 30 citations

Effect of Sputum Induction on Spirometric Measurements and Arterial Oxygen Saturation in Asthmatic patients, Smokers, and Healthy Subjects

1999 • 29 citations

Dexamethasone Increases Survival and Attenuates Induction of Inducible Nitric Oxide Synthase in Experimental Skin Flaps

1999 • 25 citations

Role of Endogenous Nitric Oxide in Airflow Obstruction in Smokers

1996 • 24 citations

[Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression].

1998 • 20 citations

Decreased Exhaled Nitric Oxide in Mild Persistent Asthma Patients Treated with a Leukotriene Receptor Antagonist, Pranlukast.

1999 • 20 citations

Eosinophilic inflammation assessed by induced sputum in corticosteroid-dependent asthma

1999 • 19 citations

Prostaglandins mediate bradykinin-induced reduction of exhaled nitric oxide in asthma

1999 • 19 citations

Effect of nitric oxide synthesis inhibition with nebulized L-NAME on ventilation-perfusion distributions in bronchial asthma

1998 • 15 citations

Lack of Inhibitory Effect of Dexamethasone on Exhalation of Nitric Oxide by Healthy Humans.

1996 • 7 citations

Comparison of exhaled nitric oxide, serum eosinophilic cationic protein, and soluble interleukin‐2 receptor in exacerbations of pediatric asthma

1997 • 3 citations

Inhaled flunisolide can prevent an increase in exhaled nitric oxide levels in allergic asthmatic children exposed to relevant allergens

1998 • 2 citations