Disruption of T Cell Tolerance to Self-Immunoglobulin Causes Polyclonal B Cell Stimulation Followed by Inactivation of Responding Autoreactive T Cells

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

Determination of free amino groups in proteins by trinitrobenzenesulfonic acid

1966 • 2,029 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

1998 • 890 citations

Natural autoantibodies

1995 • 569 citations

Induction of self-tolerance in mature peripheral B lymphocytes

1989 • 525 citations

Autoimmune Diseases: The Failure of Self Tolerance

1990 • 495 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo.

1995 • 410 citations

The phenotype and fate of the antibody‐forming cells of the splenic foci

1996 • 340 citations

Self-reactive antibodies (natural autoantibodies) in healthy individuals

1998 • 326 citations

Scavenger receptors in innate immunity

1996 • 325 citations

Maintenance of B-cell memory by long-lived cells generated from proliferating precursors

1990 • 323 citations

Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast.

1991 • 266 citations

Breakdown of self-tolerance in anergic B lymphocytes

1991 • 254 citations

Induction of autoreactive B cells allows priming of autoreactive T cells.

1991 • 253 citations

Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras.

1989 • 245 citations

Accessory Molecule and Costimulation Requirements for CD4 T Cell Response

1997 • 231 citations

Expression of syndecan regulates human myeloma plasma cell adhesion to type I collagen

1993 • 230 citations

Programmed death of autoreactive thymocytes

1990 • 224 citations

Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells.

1992 • 214 citations

Maintenance of in Vivo Tolerance by Persistence of Antigen

1992 • 209 citations

Infectious tolerance

1998 • 198 citations

Circulating plasma cells in multiple myeloma: characterization and correlation with disease stage

1997 • 185 citations

The germinal center: a crucible for lymphocyte selection

1996 • 166 citations

Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.

1993 • 164 citations

The Need for Central and Peripheral Tolerance in the B Cell Repertoire

1990 • 154 citations

Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen

1992 • 128 citations

Dendritic cells are the most efficient in presenting endogenous naturally processed self-epitopes to class II-restricted T cells.

1995 • 125 citations

Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo.

1995 • 123 citations

Tolerance in Transgenic Mice Expressing Major Histocompatibility Molecules Extrathymically on Pancreatic Cells

1990 • 117 citations

Modulation of immunogenicity and antigenicity of proteins by maleylation to target scavenger receptors on macrophages.

1995 • 109 citations

Scavenger receptor-mediated recognition of maleyl bovine plasma albumin and the demaleylated protein in human monocyte macrophages.

1985 • 101 citations

Neutrophil migration induced by inflammatory stimuli is reduced by macrophage depletion

1988 • 81 citations

Positive and Negative Thymocyte Selection

1998 • 72 citations

In vivo induction of tolerance in murine CD4+ cell subsets.

1993 • 68 citations

Thyroid autoimmunity and aging

1998 • 68 citations

Clonal deletion as direct consequence of an in vivo T cell response to bacterial superantigen

1993 • 68 citations

Modulation of T Cell Cytokine Profiles and Peptide-MHC Complex Availability In Vivo by Delivery to Scavenger Receptors via Antigen Maleylation

1998 • 60 citations

Understanding the Mechanisms of Sustained Signaling and T Cell Activation

1997 • 60 citations

Presence in peripheral blood of healthy individuals of autoreactive T cells to a membrane antigen present on bone marrow-derived cells

1996 • 56 citations

Disruption of T cell tolerance by directing a self antigen to macrophage-specific scavenger receptors.

1997 • 53 citations

Quantitative analysis of T cell activation: role of TCR/ligand density and TCR affinity.

1996 • 49 citations

Immunoglobulin‐specific T‐B cell interaction

1989 • 49 citations

Selective delivery of drugs to macrophages through a highly specific receptor

1989 • 47 citations

Thymus function, ageing and autoimmunity

1994 • 43 citations

Balancing Immunity, Autoimmunity, and Self‐tolerance^a

1997 • 39 citations

Killing of intracellular Mycobacterium tuberculosis by receptor-mediated drug delivery

1991 • 35 citations

In vivo depletion of macrophages by desulfated ι-carrageenan in mice

1989 • 24 citations

Induction of tolerance in freshly isolated alloreactive CD4⁺ T cells by activated T cell stimulators

1994 • 23 citations

Age-associated changes in the B-cell repertoire: effect of age on RAG-1 gene expression in murine bone marrow

1994 • 16 citations