Meta-Analysis: Pharmacologic Treatment of Obesity

Meta-analysis in clinical trials

1986 • 36,193 citations

Quantifying heterogeneity in a meta‐analysis

2002 • 31,236 citations

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

2002 • 18,132 citations

Assessing the quality of reports of randomized clinical trials: Is blinding necessary?

1996 • 17,261 citations

Operating Characteristics of a Rank Correlation Test for Publication Bias

1994 • 15,160 citations

Statistical Methods for Meta-Analysis

1988 • 10,595 citations

Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: The evidence report

1998 • 9,277 citations

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

2003 • 7,305 citations

Prevalence and Trends in Obesity Among US Adults, 1999-2000

2002 • 6,312 citations

The Disease Burden Associated With Overweight and Obesity

1999 • 5,006 citations

The Continuing Epidemics of Obesity and Diabetes in the United States

2001 • 2,803 citations

Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991

1994 • 2,623 citations

The Spread of the Obesity Epidemic in the United States, 1991-1998

1999 • 2,316 citations

XENical in the Prevention of Diabetes in Obese Subjects (XENDOS) Study

2004 • 1,832 citations

Medical Hazards of Obesity

1993 • 1,428 citations

Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients

1998 • 1,171 citations

The spread of the obesity epidemic in the United States

1999 • 1,034 citations

Weight Control and Risk Factor Reduction in Obese Subjects Treated for 2 Years With Orlistat

1999 • 931 citations

American Heart Association Call to Action: Obesity as a Major Risk Factor for Coronary Heart Disease

1998 • 820 citations

Dual Effects of Weight and Weight Gain on Breast Cancer Risk

1997 • 813 citations

Role of Orlistat in the Treatment of Obese Patients With Type 2 Diabetes: A 1-year randomized double-blind study

1998 • 655 citations

Weight Loss, Weight Maintenance, and Improved Cardiovascular Risk Factors after 2 Years Treatment with Orlistat for Obesity

2000 • 468 citations

Orlistat in the Long-term Treatment of Obesity in Primary Care Settings

2000 • 365 citations

Long-term maintenance of weight loss after a very-low-calorie diet: a randomized blinded trial of the efficacy and tolerability of sibutramine

1999 • 358 citations

A 6-Month Randomized, Placebo-Controlled, Dose-Ranging Trial of Topiramate for Weight Loss in Obesity

2003 • 342 citations

Bupropion SR Enhances Weight Loss: A 48‐Week Double‐Blind, Placebo‐ Controlled Trial

2002 • 322 citations

Clinical Efficacy of Orlistat Therapy in Overweight and Obese Patients With Insulin-Treated Type 2 Diabetes

2002 • 308 citations

Current and Potential Drugs for Treatment of Obesity

1999 • 302 citations

Orlistat, a lipase inhibitor, for weight maintenance after conventional dieting: a 1-y study

1999 • 292 citations

Pharmacotherapy for obesity: a quantitative analysis of four decades of published randomized clinical trials

2002 • 292 citations

Zonisamide for Weight Loss in Obese Adults

2003 • 283 citations

Effect of Orlistat in Overweight and Obese Patients With Type 2 Diabetes Treated With Metformin

2002 • 274 citations

Weight loss attempts in adults: goals, duration, and rate of weight loss.

1992 • 265 citations

The Efficacy and Safety of Sibutramine for Weight Loss

2004 • 253 citations

A review of long-term studies evaluating the efficacy of weight loss in ameliorating disorders associated with obesity

1996 • 230 citations

The effect of orlistat on body weight and coronary heart disease risk profile in obese patients: The Swedish Multimorbidity Study

2000 • 208 citations

Bupropion SR vs. Placebo for Weight Loss in Obese Patients with Depressive Symptoms

2002 • 206 citations

The Canadian obesity epidemic, 1985-1998.

2002 • 194 citations

A double-blind, placebo-controlled trial of fluoxetine plus behavior modification in the treatment of obese binge-eaters and non-binge- eaters

1990 • 192 citations

A Randomized Trial of Sibutramine in the Management of Obese Type 2 Diabetic Patients Treated With Metformin

2003 • 170 citations

The effects of orlistat on weight and on serum lipids in obese patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled, multicentre study

2001 • 165 citations

Fluoxetine: a randomized clinical trial in the treatment of obesity.

1994 • 162 citations

Evaluation of the safety and efficacy of sibutramine, orlistat and metformin in the treatment of obesity

2002 • 161 citations

Randomized placebo-controlled trial of long-term treatment with sibutramine in mild to moderate obesity.

2001 • 152 citations

A dose-comparison trial of topiramate as monotherapy in recently diagnosed partial epilepsy

2003 • 151 citations

The effects of orlistat on body weight and glycaemic control in overweight patients with type 2 diabetes: a randomized, placebo‐controlled trial

2002 • 142 citations

Effects of Sibutramine Plus Orlistat in Obese Women Following 1 Year of Treatment by Sibutramine Alone: A Placebo‐Controlled Trial

2000 • 122 citations

Fluoxetine's effect on weight loss in obese subjects

1991 • 115 citations

Effect of orlistat-assisted weight loss in decreasing coronary heart disease risk in patients with syndrome X

2001 • 113 citations

Epidemic of Obesity Expands Its Spread to Developing Countries

2002 • 100 citations

RANDOMISED TRIAL OF THE EFFECT OF ORLISTAT ON BODY WEIGHT AND CARDIOVASCULAR DISEASE RISK PROFILE IN OBESE PATIENTS: UK MULTIMORBIDITY STUDY

2002 • 97 citations

Fluoxetine in the Treatment of Obese Type 2 Diabetic Patients

1994 • 96 citations

Orlistat improves blood pressure control in obese subjects with treated but inadequately controlled hypertension

2002 • 93 citations

Weight reduction and long-term maintenance after 18 months treatment with orlistat for obesity

2003 • 92 citations

Long-term effects of fluoxetine on glycemic control in obese patients with non-insulin-dependent diabetes mellitus or glucose intolerance: Influence on muscle glycogen synthase and insulin receptor kinase activity

1995 • 86 citations

The weight loss experience: A descriptive analysis

2004 • 79 citations

Effect on body weight of bupropion sustained-release in patients with major depression treated for 52 weeks

2002 • 77 citations

Weight Reduction by Sibutramine in Obese Subjects in Primary Care Medicine: The S. A. T. Study

2004 • 75 citations

Latin‐American trial of orlistat for weight loss and improvement in glycaemic profile in obese diabetic patients

2003 • 71 citations

Randomized, double-blind, placebo-controlled comparison of the action of orlistat, fluvastatin, or both an anthropometric measurements, blood pressure, and lipid profile in obese patients with hypercholesterolemia prescribed a standardized diet

2003 • 69 citations

Possible association of ischemic stroke with phentermine.

1993 • 65 citations

Effect of orlistat treatment on body composition and resting energy expenditure during a two-year weight-reduction programme in obese Finns

2000 • 63 citations

Sertraline and Relapse Prevention Training Following Treatment by Very‐Low‐Calorie Diet: A Controlled Clinical Trial

1995 • 63 citations

A Study of Fluoxetine in Obese Elderly Patients with Type 2 Diabetes

1995 • 59 citations

Weight change and blood coagulability and fibrinolysis in healthy obese women

2001 • 58 citations

Fluoxetine treatment of the obese diabetic.

1992 • 58 citations

Effect of orlistat added to diet (30% of calories from fat) on plasma lipids, glucose, and insulin in obese patients with hypercholesterolemia

2003 • 55 citations

Influence of orlistat on bone turnover and body composition

2001 • 52 citations

Sertraline, a serotonin-uptake inhibitor, reduces food intake and body weight in lean rats and genetically obese mice

1992 • 45 citations

Obesity Treatment: Examining the Premises

1995 • 44 citations

Minor long‐term changes in weight have beneficial effects on insulin sensitivity and β‐cell function in obese subjects

2002 • 41 citations

Long-term weight loss with sibutramine. A randomized controlled trial

2002 • 37 citations

Weight Gain Mitigation with Topiramate in Mood Disorders

2004 • 16 citations

The effect of orlistat on the fatty acid composition of serum lipid fractions in obese subjects

1999 • 15 citations

Orlistat, a gastrointestinal lipase inhibitor, in therapy of obesity with concomitant hyperlipidemia.

2000 • 14 citations

[Six-month xenical (orlistat) therapy of patients with stable angina pectoris concomitant with obesity and hyperlipidemia].

2002 • 5 citations

Acute vasospasm associated with anorexiant use.

1988 • 5 citations

[Effectiveness of serotonergic agonists in the treatment of obese patients].

1995 • 4 citations