ALCOHOL AND PORPHYRIN METABOLISM

The Induction in Vitro of the Synthesis of δ-Aminolevulinic Acid Synthetase in Chemical Porphyria: A Response to Certain Drugs, Sex Hormones, and Foreign Chemicals

1966 • 764 citations

Intermediates and Products of the Biohydrogenation of Linoleic Acid by Butyrivibrio fibrisolvens

1966 • 694 citations

Effect of ethanol on liver 8-aminolaevulinate synthetase in rats.

1968 • 430 citations

Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA.

1991 • 374 citations

Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.

1991 • 349 citations

Hepatitis C virus and porphyria cutanea tarda: Evidence of a strong association

1992 • 298 citations

An inherited enzymatic defect in porphyria cutanea tarda: decreased uroporphyrinogen decarboxylase activity.

1976 • 283 citations

Enalapril (MK -421) and the white cell count and haematocrit [ letter ]

1982 • 275 citations

Porphyria Cutanea Tarda

1998 • 270 citations

Porphyria cutanea tarda

1979 • 248 citations

Pharmacogenetics. Heredity and the Response to Drugs.

1963 • 233 citations

Münchener Medizinische Wochenschrift

1968 • 212 citations

Decreased Activity of Hepatic Uroporphyrinogen Decarboxylase in Sporadic Porphyria Cutanea Tarda

1978 • 204 citations

PORPHYRIN CONTENT OF BONE MARROW AND LIVER IN THE VARIOUS FORMS OF PORPHYRIA

1954 • 198 citations

Selective blockade of NMDA‐activated channel currents may be implicated in learning deficits caused by lead

1990 • 191 citations

Early Administration of Heme Arginate for Acute Porphyric Attacks

1993 • 184 citations

Familial and sporadic porphyria cutanea

1978 • 181 citations

Purification and properties of delta-aminolevulinate dehydrase from human erythrocytes.

1979 • 177 citations

Long-term potentiation in rat hippocampus is inhibited by low concentrations of ethanol

1990 • 169 citations

Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria

1996 • 157 citations

Induction of δ-Aminolevulinic Acid Synthetase in Chick Embryo Liver Cells in Culture

1970 • 151 citations

Inheritance in Erythropoietic Protoporphyria: A Common Wild-Type Ferrochelatase Allelic Variant With Low Expression Accounts for Clinical Manifestation

1999 • 147 citations

Molecular Epidemiology and Diagnosis of PBG Deaminase Gene Defects in Acute Intermittent Porphyria

1997 • 147 citations

Purification and properties of uroporphyrinogen decarboxylase from human erythrocytes. A single enzyme catalyzing the four sequential decarboxylations of uroporphyrinogens I and III.

1983 • 138 citations

Hepatic microsomal alcohol-oxidizing system. Affinity for methanol, ethanol, propanol, and butanol.

1975 • 136 citations

Diseases of Porphyrin Metabolism

1963 • 127 citations

HEPATOERYTHROPOIETIC PORPHYRIA: A NEW UROPORPHYRINOGEN DECARBOXYLASE DEFECT OR HOMOZYGOUS PORPHYRIA CUTANEA TARDA?

1981 • 124 citations

Porphyria cutanea tarda and antibodies to hepatitis C virus

1993 • 113 citations

Alcoholism, Alcohol, and Drugs

1971 • 113 citations

Purification and properties of coproporphyrinogenase

1965 • 111 citations

Ethanol metabolism and ethanol-drug interactions

1976 • 110 citations

Depression of δ-Aminolaevulic Acid Dehydrase Activity by Ethanol in Man and Rat

1971 • 103 citations

Synergism of iron and hexachlorobenzene inhibits hepatic uroporphyrinogen decarboxylase in inbred mice

1983 • 102 citations

The Effect of the Porphyrogenic Compound, Hexachlorobenzene, on the Activity of Hepatic Uroporphyrinogen Decarboxylase in the Rat

1976 • 102 citations

Modulation of the phenotype in dominant erythropoietic protoporphyria by a low expression of the normal ferrochelatase allele.

1996 • 98 citations

Low prevalence of hepatitis C virus infection in porphyria cutanea tarda in germany

1995 • 96 citations

Hepatic ethanol metabolism: Respective roles of alcohol dehydrogenase, the microsomal ethanol-oxidizing system, and catalase

1976 • 89 citations

Identification of three mutations and associated haplotypes in the protoporphyrinogen oxidase gene in South African families with variegate porphyria

1996 • 86 citations

Hepatitis C virus‐related autoimmunity in patients with porphyria cutanea tarda

1993 • 83 citations

Decreased Hepatic Uroporphyrinogen Decarboxylase Activity in Porphyria Cutanea Tarda

1982 • 82 citations

Dual mechanism of inhibition of rat liver uroporphyrinogen decarboxylase activity by ferrous iron: Its potential role in the genesis of porphyria cutanea tarda

1984 • 77 citations

Molecular injury to mitochondria produced by ethanol and acetaldehyde.

1975 • 76 citations

Uroporphyrinogen decarboxylase: complete human gene sequence and molecular study of three families with hepatoerythropoietic porphyria.

1996 • 74 citations

International review of drugs in acute porphyria—1980

1980 • 72 citations

Mutations in the protoporphyrinogen oxidase gene in patients with variegate porphyria

1996 • 69 citations

Regulation by heme of synthesis and intracellular translocation of δ-aminolevulinate synthase in the liver

1981 • 68 citations

Identification of Two Types of Porphyria Cutanea Tarda by Measurement of Erythrocyte Uroporphyrinogen Decarboxylase

1980 • 67 citations

Prophyria cutanea tarda and hepatitis C and B viruses infection: A retrospective study

1995 • 66 citations

Homozygous hereditary coproporphyria caused by an arginine to tryptophane substitution in coproporphyrinogen oxidase and common intragenic polymorphisms

1994 • 65 citations

Hepatic pathology in porphyria cutanea tarda

1983 • 65 citations

Acute ethanol ingestion and haem biosnthesis in health subjects

1980 • 64 citations

Long-term potentiation in rat hippocampal slices is impaired following acute lead perfusion

1991 • 61 citations

PORPHYRIA CUTANEA TARDA AND HUMAN IMMUNODEFICIENCY VIRUS INFECTION

1992 • 60 citations

Acute tolerance to ethanol inhibition of NMDA-mediated EPSPs in the CA1 region of the rat hippocampus

1994 • 60 citations

Coproporphyrin I and III excretion in bile and urine

1972 • 60 citations

A molecular defect in coproporphyrinogen oxidase gene causing harderoporphyria, a variant form of hereditary coproporphyria

1995 • 58 citations

Coproporphyrinogene oxidase: gene organization and description of a mutation leading to exon 6 skipping

1994 • 58 citations

EFFECT OF ETHANOL ON LIVER δ-AMINOLÆVULINATE SYNTHETASE IN RATS

1968 • 58 citations

Analysis of uroporphyrinogen decarboxylase complementary DNAs in sporadic porphyria cutanea tarda

1993 • 57 citations

Porphyria Cutanea Tarda and Hepatitis C Viral Infection

1995 • 54 citations

Porphyria cutanea tarda: comparison of cases precipitated by alcohol and estrogens.

1975 • 54 citations

Effect of Ethanol on Liver δ‐Aminolaevulinate Synthetase Activity and Urinary Porphyrin Excretion in Symptomatic Porphyria

1969 • 53 citations

Abnormal haem biosynthesis in chronic alcoholics

1981 • 52 citations

Porphyrinurias and Occupational Disease^a

1987 • 51 citations

Deficient Heme and Globin Synthesis in Embryonic Stem Cells Lacking the Erythroid-Specific δ-Aminolevulinate Synthase Gene

1998 • 49 citations

Protoporphyrin formation in Rhizobium japonicum

1983 • 47 citations

Porphyria and the dangerous life-threatening drugs.

1979 • 47 citations

Porphyria Cutanea Tarda

1982 • 43 citations

Treatment of the Porphyrias

1994 • 43 citations

HEPATIC DRUG METABOLISM AND HAEM BIOSYNTHESIS IN LEAD‐POISONED RATS

1978 • 43 citations

Metabolism and metabolic effects of alcohol.

1980 • 43 citations

Protoporphyrinogen Oxidase: Complete Genomic Sequence and Polymorphisms in the Human Gene

1996 • 42 citations

δ-Aminolevulinic acid synthetase: Regulation of activity in various tissues of the aging rat

1978 • 41 citations

5-Aminolevulinic acid dehydratase deficiency porphyria: a twenty-year clinical and biochemical follow-up

1998 • 41 citations

Porphyrin Metabolism in Experimental Hepatic Siderosis in the Rat

1970 • 41 citations

Frequency of low erythrocyte porphobilinogen deaminase activity in Finland*

1992 • 40 citations

Hepatic porphyrias: pathobiochemical, diagnostic, and therapeutic implications.

1982 • 39 citations

Normal limits of urinary coproporphyrin excretion determined by an improved method.

1953 • 39 citations

The Hepatic Porphyrias

1976 • 38 citations

METABOLIC ANOMALIES IN PORPHYRIA THE RESULT OF IMPAIRED BIOLOGICAL OXIDATION ?

1967 • 37 citations

Recovery from porphyria cutanea tarda with no specific therapy other than avoidance of hepatic toxins

1984 • 36 citations

Studies of coproporphyrin. VI. The effect of alcohol on the per diem excretion and isomer distribution of the urinary coproporphyrins.

1951 • 35 citations

Persistent protoporphyrinemia in hereditary porphobilinogen synthase (δ-aminolevulinic acid dehydrase) deficiency under low lead exposure

1982 • 34 citations

Alcohol-Induced Decrease in Uroporphyrinogen Decarboxylase Activity in Rat Liver and Spleen

1981 • 33 citations

Gene transfer of the uroporphyrinogen III synthase cDNA into haematopoietic progenitor cells in view of a future gene therapy in congenital erythropoietic porphyria

1997 • 33 citations

Decreased uroporphyrinogen decarboxylase activity in ‘experimental symptomatic porphyria’

1971 • 33 citations

Pathobiochemical transition of secondary coproporphyrinuria to chronic hepatic porphyria in humans

1980 • 33 citations

The Biochemistry of Heme Synthesis in Porphyria and in the Porphyrinurias

1998 • 31 citations

Multiple Chemical Sensitivity Syndrome and Porphyria

1997 • 31 citations

Some Observations on Hexachlorobenzene Induced Experimental Porphyria**From the Section of Dermatology, Department of Medicine, The University of Chicago, Chicago, Illinois.

1965 • 31 citations

STUDIES OF COPROPORPHYRIN. VIII. REINVESTIGATION OF THE ISOMER DISTRIBUTION IN JAUNDICE AND LIVER DISEASES.

1964 • 31 citations

Four Novel Mutations in the Ferrochelatase Gene among Erythropoietic Protoporphyria Patients

1996 • 30 citations

Porphyria Cutanea Tarda Associated With the Acquired Immunodeficiency Syndrome

1988 • 30 citations

Ethanol Inhibition of Reticulocyte Protein Synthesis: The Role of Haem

1975 • 29 citations

Urinary Excretion of Porphyrins and Porphyrin Intermediates in Human Alcoholics

1963 • 28 citations

Hepatic porphyrins and urinary prophyrins and prophyrin precursors in liver cirrhosis

1972 • 28 citations

Porphyria cutanea tarda and hepatitis C and B viruses infection: A retrospective study

1995 • 28 citations

Porphyria Cutanea Tarda of the Toxic and Sporadic Varieties

1998 • 28 citations

Characterization and expression of cDNA encoding coproporphyrinogen oxidase from a patient with hereditary coproporphyria

1994 • 28 citations

Depression of Erythrocyte δ-Aminolaevulinic Acid Dehydratase Activity in Alcoholics

1974 • 28 citations

Congenital Erythropoietic Porphyria

1982 • 26 citations

Porphyrin synthesis in hepatic cirrhosis: Increase in δ-aminolevulinic acid synthetase

1967 • 26 citations

Δ-Aminolevulinic Acid Synthetase Activity in Normal Human Bone Marrow and in Patients with Idiopathic Sideroblastic Anemia

1973 • 26 citations

The role of possible membrane damage in porphyria cutanea tarda: A spin label study of rat liver cell membranes

1982 • 26 citations

Hormonal Oral Contraceptives, Urinary Porphyrin Excretion and Porphyrias

1995 • 25 citations

Molecular Genetics of Porphyries

1990 • 25 citations

Aging-related decreases in hepatic mitochondrial and cytosolic δ-aminolevulinic acid synthase during experimental porphyria

1983 • 25 citations

Effect of alcohol on δ-aminolevulinic acid dehydratase and porphyrin metabolism in man

1991 • 25 citations

Uroporphyrinogen Decarboxylase Deficiency in Experimental Chronic Hepatic Porphyria

1980 • 24 citations

Ethanol Inhibition of Rabbit Reticulocyte Haem Synthesis at the Level of δ‐Aminolaevulinic Acid Synthetase

1979 • 24 citations

Effect of Ethanol and Zinc on ALA-Dehydratase Activity in Red Blood Cells

1976 • 24 citations

Increased inhibition of hepatic uroporphyrinogen decarboxylase by hexachlorobenzene in male rats given the oestrogenic drugs diethylstilboestrol and chlorotrianisene

1981 • 24 citations

Human Hepatic δ-Aminolaevulinate Synthase: Requirement of an Exogenous System for Succinyl-Coenzyme a Generation to Demonstrate Increased Activity in Cirrhotic and Anticonvulsant-Treated Subjects

1977 • 24 citations

Iron and the liver: acute effects of iron-loading on hepatic heme synthesis of rats. Role of decreased activity of 5-aminolevulinate dehydrase.

1983 • 23 citations

Effect of Alcohol on the Heme and Porphyrin Synthesis Interaction with Phenobarbital and Pyrazole

1977 • 23 citations

δ‐aminolevulinic acid dehydrase (porphobilinogen synthase) in two families with inherited enzyme deficiency

1986 • 22 citations

Hereditary coproporphyria: Exon screening by heteroduplex analysis detects three novel mutations in the coproporphyrinogen oxidase gene

1997 • 22 citations

Immunological, enzymatic and biochemical studies of uroporphyrinogen III‐synthase deficiency in 20 patients with congenital erythropoietic porphyria

1998 • 21 citations

Molecular abnormalities of coproporphyrinogen oxidase in patients with hereditary coproporphyria

1995 • 20 citations

Differenzierung hepatischer Porphyrinurien

1971 • 20 citations

Variegate Porphyria and Heavy Metal Poisoning From Ingestion of “Moonshine”

1983 • 20 citations

Influence of chronic alcohol consumption on hepatic heme and porphyrin metabolism

1987 • 18 citations

Decreased Liver δ-Aminolaevulinate Dehydratase Activity in Porphyria Cutanea Tarda and in Alcoholism

1983 • 18 citations

Assessment of erythrocyte δ-aminolaevulinate dehydratase for outpatient detection of alcoholic liver disease: Comparison with γ-glutamyltransferase and casual blood ethanol

1979 • 17 citations

Evaluation of porphyria cutanea tarda in U.S. workers exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin

1994 • 17 citations

Further Discussion Concerning Porphyria Cutanea Tarda and TCDD Exposure

1986 • 17 citations

Alcohol-mediated effects on the level of cytochrome P-450 and heme biosynthesis in cultured rat hepatocytes

1983 • 17 citations

Changes in Aminolevulinate Synthase and Aminolevulinate Dehydratase Activity in Cirrhotic Liver

1983 • 16 citations

Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in human liver biopsies with special reference to alcoholic liver disease

1989 • 16 citations

Urinary Porphyrins in Liver Disease

1984 • 15 citations

Chronische hepatische Porphyrie mit Uroporphyrinogen-Decarboxylase-Defekt in vier Generationen

2008 • 15 citations

Effect of hexachlorobenzene on the activities of hepatic alcohol metabolizing enzymes

1983 • 15 citations

Zinc Aminolevulinic Acid Dehydratase Reactivation Index as a Tool for Diagnosis of Lead Exposure

1995 • 15 citations

Enzyme Assays and the Porphyrias: Which Tissues and When Indicated

1998 • 15 citations

Alcohol-induced changes in urinary aminolevulinic acid and porphyrins: Unrelated to liver disease

1996 • 15 citations

Decreased erythrocyte δ-aminolevulinate dehydratase activity after styrene exposure

1987 • 15 citations

The Control of σ-Aminolevulinic Acid Synthetase in Rat Liver Mitochondria

1973 • 14 citations

Krankheitsbilder bei Leberschädigung durch Alkohol

1965 • 12 citations

Toxic porphyrinuria following chronic alcoholism.

1937 • 12 citations

Haem biosynthesis in cutaneous hepatic porphyria: comparison with alcoholism and liver disease.

1979 • 12 citations

Control of heme biosynthesis

1970 • 10 citations

Increased bone marrow delta‐aminolevulinic acid synthetase activity in the acute reversible sideroblastic anemia of alcoholics

1980 • 9 citations

[Influence of diet, glycine and alcohol on porphyrinuria in chronic hepatitic porphyria].

1971 • 9 citations

Effects of Ethanol on the Absorption and Retention of Lead

1978 • 8 citations

Effects of alcohol on inborn errors of metabolism: porphyria cutanea tarda and hemochromatosis.

1980 • 8 citations

Iron absorption during the development of hexachlorobenzene-induced porphyria in rats

1982 • 7 citations

A novel mutation of coproporphyrinogen oxidase (CPO) gene in a Japanese family

1998 • 7 citations

Regulation of Heme Biosynthesis in Hepatic and Erythroid Cells: A Brief Introduction to the Pathobiochemistry of Human Porphyrias

1978 • 7 citations

Parallel changes in cytoplasmic and mitochondrial redox state of rat liver. effects of ethanol, sorbitol and thyroid hormones

1969 • 7 citations

Study of erythrocyte ?-aminolevulinic acid dehydratase activity in porphyria cutanea tarda

1979 • 6 citations

Ethanol inhibition of reduced frequency-dependent rundown of calcium currents in acutely dissociated MS/nDB neurons from chronic in vivo lead-exposed adult rats.

1997 • 5 citations

Coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase activities in iron‐overloaded and ethanol‐treated rats

1990 • 5 citations

High performance liquid chromatographic studies of erythrocyte haem biosynthetic enzyme activities in alcoholic macrocytosis

1990 • 4 citations

Urinary Excretion of Coproporphyrin in Alcoholics; Studies on “Single-Voiding” Samples

1972 • 4 citations

Porphyria in Australia

2015 • 4 citations

Additive inhibition of in vitro rabbit reticulocyte heme and protein synthesis with combinations of isoniazid, chloramphenicol and ethanol

1979 • 3 citations

[Porphyria cutanea tarda and human immunodeficiency virus infection].

1993 • 3 citations