Breast Cancer Cells Interact with Osteoblasts to Support Osteoclast Formation1

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

1997 • 5,058 citations

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

1998 • 4,184 citations

Mechanisms of Bone Metastasis

2004 • 2,680 citations

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

1998 • 2,473 citations

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

1997 • 2,257 citations

Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesisin Vitro¹

1998 • 1,211 citations

TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells

1997 • 1,054 citations

Efficacy of Pamidronate in Reducing Skeletal Complications in Patients with Breast Cancer and Lytic Bone Metastases

1996 • 1,023 citations

OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION

1988 • 943 citations

TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

1997 • 869 citations

Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis.

1996 • 846 citations

Reduction in New Metastases in Breast Cancer with Adjuvant Clodronate Treatment

1998 • 811 citations

TRANCE Is Necessary and Sufficient for Osteoblast-mediated Activation of Bone Resorption in Osteoclasts

1998 • 571 citations

The Bone Marrow-Derived Stromal Cell Lines MC3T3-G2/PA6 and ST2 Support Osteoclast-Like Cell Differentiation in Cocultures with Mouse Spleen Cells

1989 • 501 citations

Cancer and Bone*

1998 • 491 citations

Osteotropic Agents Regulate the Expression of Osteoclast Differentiation Factor and Osteoprotegerin in Osteoblastic Stromal Cells

1998 • 444 citations

Resorption of bone by isolated rabbit osteoclasts

1984 • 423 citations

A Combination of Osteoclast Differentiation Factor and Macrophage-Colony Stimulating Factor Is Sufficient for both Human and Mouse Osteoclast Formation in Vitro

1998 • 418 citations

Mechanisms of bone metastasis

1997 • 416 citations

Interleukin-18 (Interferon-γ–inducing Factor) Is Produced by Osteoblasts and Acts Via Granulocyte/Macrophage Colony-stimulating Factor and Not Via Interferon-γ to Inhibit Osteoclast Formation

1997 • 381 citations

A murine model of experimental metastasis to bone and bone marrow.

1988 • 350 citations

Transforming Growth Factor-β Stimulates the Production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by Bone Marrow Stromal Cells

1998 • 301 citations

Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells

1997 • 281 citations

The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma.

1997 • 218 citations

Parathyroid hormone-related protein and bone metastases

1997 • 174 citations

Journal of Bone and Mineral Research

1993 • 174 citations

Induction of Calcitonin Receptors by lα, 25- Dihydroxyvitamin D₃in Osteoclast-Like Multinucleated Cells Formed from Mouse Bone Marrow Cells*

1988 • 169 citations

Interleukins in the Control of Osteoclast Differentiation

1998 • 113 citations

Calcitonin receptors, bone sialoprotein and osteopontin are expressed in primary breast cancers

1997 • 104 citations

Modified Immunoradiometric Assay of Parathyroid Hormone-Related Protein: Clinical Application in the Differential Diagnosis of Hypercalcemia

1992 • 103 citations

Transforming growth factor β stimulation of parathyroid hormone-related protein (PTHrP): A paracrine regulator?

1993 • 90 citations

Role of cytokines in bone resorption

1993 • 82 citations

Alternative promoter usage and mRNA splicing pathways for parathyroid hormone-related protein in normal tissues and tumours

1995 • 77 citations

Effect of Transforming Growth Factor-β1 on Parathyroid Hormone-Related Protein Secretion and mRNA Expression by Normal Human Keratinocytes In Vitro

1998 • 34 citations