Parathyroid hormone-related protein and bone metastases

THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.

1889 • 4,920 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

A Parathyroid Hormone-Related Protein Implicated in Malignant Hypercalcemia: Cloning and Expression

1987 • 1,293 citations

The clinical course of bone metastases from breast cancer

1987 • 1,080 citations

Efficacy of Pamidronate in Reducing Skeletal Complications in Patients with Breast Cancer and Lytic Bone Metastases

1996 • 1,023 citations

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

1992 • 1,009 citations

Breast Tumor Cell Lines From Pleural Effusions2

1974 • 973 citations

Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose.

1986 • 870 citations

Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis.

1996 • 846 citations

Parathyroid hormone-related protein purified from a human lung cancer cell line.

1987 • 735 citations

Double-blind controlled trial of oral clodronate in patients with bone metastases from breast cancer.

1993 • 567 citations

Immunochemical Characterization of Circulating Parathyroid Hormone–Related Protein in Patients with Humoral Hypercalcemia of Cancer

1990 • 554 citations

Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.

1987 • 533 citations

Transforming Growth Factor-β Gene Family Members and Bone*

1994 • 493 citations

Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones.

1987 • 434 citations

Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice.

1995 • 421 citations

Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites.

1991 • 384 citations

Parathyroid Hormone-Related Protein of Malignancy: Active Synthetic Fragments

1987 • 374 citations

Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.

1987 • 373 citations

Similarity of Synthetic Peptide from Human Tumor to Parathyroid Hormone in Vivo and in Vitro

1987 • 357 citations

A murine model of experimental metastasis to bone and bone marrow.

1988 • 350 citations

Parathyroid Hormone-Related Protein: Elevated Levels in both Humoral Hypercalcemia of Malignancy and Hypercalcemia Complicating Metastatic Breast Cancer*

1991 • 288 citations

TGF-β-receptor-mediated signaling

1994 • 274 citations

Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents.

1988 • 271 citations

Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo.

1995 • 260 citations

Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer.

1990 • 243 citations

Parathyroid hormone-related protein: Immunohistochemical localization in cancers and in normal skin

1989 • 225 citations

Metastases from carcinoma of mammary gland: An autopsy study

1979 • 213 citations

Signaling Activity of Transforming Growth Factor β Type II Receptors Lacking Specific Domains in the Cytoplasmic Region

1993 • 207 citations

REDUCED MORBIDITY FROM SKELETAL METASTASES IN BREAST CANCER PATIENTS DURING LONG-TERM BISPHOSPHONATE (APD) TREATMENT

1987 • 206 citations

Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development

1995 • 204 citations

Comments on hematogenous metastatic patterns in humans as revealed by autopsy

1992 • 191 citations

Histomorphometric evidence for osteoclast-mediated bone resorption in metastatic breast cancer

1994 • 170 citations

Scanning electron microscopy in bone pathology: review of methods, potential and applications.

1986 • 160 citations

Parathyroid Hormone-Like Peptide in Normal and Neoplastic Human Endocrine Tissues*

1990 • 159 citations

Localization of parathyroid hormone‐related protein mrna expression in breast cancer and metastatic lesions by in situ hybridization

1992 • 151 citations

The mRNA Encoding a Parathyroid Hormone-Like Peptide is Produced in Mammary Tissue in Response to Elevations in Serum Prolactin

1989 • 142 citations

The Management of Cancer Metastatic to Bone

1994 • 135 citations

Regulation of parathyroid hormone-like peptide in cultured normal human keratinocytes. Effect of growth factors and 1,25 dihydroxyvitamin D3 on gene expression and secretion.

1991 • 134 citations

Parathyroid hormone related protein and skeletal morbidity in breast cancer

1992 • 131 citations

Angiotensin II regulates parathyroid hormone-related protein expression in cultured rat aortic smooth muscle cells through transcriptional and post-transcriptional mechanisms.

1993 • 131 citations

Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region.

1993 • 122 citations

Intravenous pamidronate disodium treatment of bone metastases in patients with breast cancer. A dose-seeking study

1994 • 108 citations

Parathyroid hormone related protein and hypercalcaemia in breast cancer.

1991 • 95 citations

Polymerase chain reaction analysis of parathyroid hormone-related protein gene expression in breast cancer patients and occurrence of bone metastases.

1993 • 93 citations

Sclerosis of lytic bone metastases after disodium aminohydroxypropylidene bisphosphonate (APD) in patients with breast carcinoma.

1988 • 92 citations

Transforming growth factor β stimulation of parathyroid hormone-related protein (PTHrP): A paracrine regulator?

1993 • 90 citations

Effect of the bisphosphonate risedronate on bone metastases in a rat mammary adenocarcinoma model system

1994 • 75 citations

Expression of parathyroidlike protein in normal, proliferative, and neoplastic human breast tissues.

1993 • 71 citations

Alterations in transforming growth factor-alpha and -beta production and cell responsiveness during the progression of MCF-7 human breast cancer cells to estrogen-autonomous growth.

1994 • 69 citations

Effects of transforming growth factor-beta on parathyroid hormone-related protein production and ribonucleic acid expression by a squamous carcinoma cell line in vitro.

1994 • 64 citations

Parathyroid hormone-related peptide is a downstream target for ras and src activation.

1994 • 59 citations

Regulation of parathyroid hormone-related peptide production in normal human mammary epithelial cells in vitro

1994 • 59 citations

Cell-specific and regulator-induced promoter usage and messenger ribonucleic acid splicing for parathyroid hormone-related protein.

1996 • 58 citations

Glucocorticoid Regulation of Parathyroid Hormone-Related Peptide Gene Transcription in a Human Neuroendocrine Cell Line

1989 • 55 citations

Regulation of parathyroid hormone-related protein production in a human lung squamous cell carcinoma line

1994 • 49 citations

TGF-( -receptor-mediated signaling

1994 • 46 citations

Dexamethasone regulation of parathyroid hormone-related protein (PTHrP) expression in a squamous cancer cell line

1994 • 42 citations

Transforming growth factor beta secretion from primary breast cancer fibroblasts

1995 • 41 citations

Parathyroid hormone‐related peptide can regulate the growth of human lung cancer cells, and may form part of an autocrine TGF‐α loop

1992 • 36 citations

SYNTHETIC AND PARTIALLY-PURIFIED ADENYLATE CYCLASE-STIMULATING PROTEINS FROM TUMORS ASSOCIATED WITH HUMORAL HYPERCALCEMIA OF MALIGNANCY INHIBIT PHOSPHATE TRANSPORT IN A PTH-RESPONSIVE RENAL CELL LINE

1988 • 35 citations

Hypercalcemia in breast cancer

1993 • 34 citations

Treatment of skeletal disease in breast cancer with clodronate

1991 • 32 citations

Effects of epidermal growth factor on parathyroid hormone-related protein production by mammary epithelial cells

1994 • 28 citations

Long-term follow up of breast cancer patients treated for hypercalcaemia with aminohydroxypropylidene bisphosphonate (APD)

1993 • 13 citations