How Many SNPs Does a Genome-Wide Haplotype Map Require?

A Mathematical Theory of Communication

1948 • 73,365 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

A New Statistical Method for Haplotype Reconstruction from Population Data

2001 • 7,499 citations

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

2001 • 2,948 citations

Parametric and nonparametric linkage analysis: a unified multipoint approach.

1996 • 2,905 citations

Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population.

1995 • 1,977 citations

Searching for genetic determinants in the new millennium

2000 • 1,878 citations

Linkage disequilibrium in the human genome

2001 • 1,779 citations

High-resolution haplotype structure in the human genome

2001 • 1,752 citations

Prospects for whole-genome linkage disequilibrium mapping of common disease genes

1999 • 1,453 citations

DNA POLYMORPHISM DETECTABLE BY RESTRICTION ENDONUCLEASES

1981 • 1,346 citations

The essence of SNPs

1999 • 1,316 citations

Are Rare Variants Responsible for Susceptibility to Complex Diseases?

2001 • 1,224 citations

Haplotype tagging for the identification of common disease genes

2001 • 1,188 citations

Blocks of Limited Haplotype Diversity Revealed by High-Resolution Scanning of Human Chromosome 21

2001 • 1,168 citations

Accessing genetic variation: genotyping single nucleotide polymorphisms

2001 • 1,073 citations

Haplotype Variation and Linkage Disequilibrium in 313 Human Genes

2001 • 879 citations

New Goals for the U.S. Human Genome Project: 1998-2003

1998 • 848 citations

A DNA Polymorphism Discovery Resource for Research on Human Genetic Variation: Table 1.

1998 • 815 citations

Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease

2001 • 789 citations

Inference of haplotypes from PCR-amplified samples of diploid populations.

1990 • 773 citations

Sequence variation in the human angiotensin converting enzyme

1999 • 490 citations

Haplotypes vs single marker linkage disequilibrium tests: what do we gain?

2001 • 444 citations

Haplotype Structure and Population Genetic Inferences from Nucleotide-Sequence Variation in Human Lipoprotein Lipase

1998 • 439 citations

Genetic Analysis of Case/Control Data Using Estimated Haplotype Frequencies: Application to APOE Locus Variation and Alzheimer's Disease

2001 • 432 citations

Apolipoprotein E Variation at the Sequence Haplotype Level: Implications for the Origin and Maintenance of a Major Human Polymorphism

2000 • 413 citations

Linkage disequilibrium and the mapping of complex human traits

2002 • 399 citations

The sequence of the human genome. Venter JC, Adams MD, Myers EW, et al. Science 2001;291:1304–1351.

2001 • 292 citations

Gene Index analysis of the human genome estimates approximately 120,000 genes

2000 • 282 citations

Genetic epidemiology of single-nucleotide polymorphisms

1999 • 278 citations

Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28

2000 • 259 citations

The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes

2000 • 195 citations

Single-nucleotide polymorphisms in the public domain: how useful are they?

2001 • 167 citations

Experimentally-derived haplotypes substantially increase the efficiency of linkage disequilibrium studies

2001 • 160 citations

Single nucleotide polymorphism libraries: why and how are we building them?

1999 • 154 citations

Molecular haplotyping of genetic markers 10 kb apart by allele-specific long-range PCR

1996 • 144 citations

Genotyping:The predictive power of haplotypes in clinical response

2000 • 134 citations

A draft annotation and overview of the human genome

2001 • 106 citations

HGBASE: a database of SNPs and other variations in and around human genes

2000 • 95 citations

Map of the Human Genome 3.0

2001 • 81 citations

Reich, D. E., Cargill, M. and Bolk, S. et al.. Linkage disequilibrium in the human genome. Nature, 411: 199-204

2001 • 62 citations

Assessment of the Total Number of Human Transcription Units

2001 • 53 citations

Estimation of myriad haplotype frequencies

1985 • 51 citations

Can SNPs Deliver on Susceptibility Genes?

2001 • 28 citations

Irresistible force meets immovable object: SNP mapping of complex diseases

2002 • 16 citations

From the Mouths (and Hands) of Babes

2001 • 14 citations