Shigella flexneri 2a Strain CVD 1207, with Specific Deletions in virG , sen , set , and guaBA , Is Highly Attenuated in Humans

Global burden of Shigella infections: implications for vaccine development and implementation of control strategies.

1999 • 1,261 citations

Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin.

1989 • 724 citations

Inoculum Size in Shigellosis and Implications for Expected Mode of Transmission

1989 • 590 citations

Reiter's Syndrome and Reactive Arthritis in Perspective

1983 • 463 citations

Shigella-induced Apoptosis Is Dependent on Caspase-1 Which Binds to IpaB

1998 • 407 citations

Double-blind vaccine-controlled randomised efficacy trial of an investigational Shigella sonnei conjugate vaccine in young adults

1997 • 247 citations

virG, a plasmid-coded virulence gene of Shigella flexneri: identification of the virG protein and determination of the complete coding sequence

1989 • 240 citations

Serum immune response to Shigella protein antigens in rhesus monkeys and humans infected with Shigella spp

1986 • 233 citations

Vaccination against Shigellosis with Attenuated Shigella flexneri 2a Strain SC602

1999 • 228 citations

Immunity in Shigellosis. II. Protection Induced by Oral Live Vaccine or Primary Infection

1972 • 207 citations

Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strains

1995 • 179 citations

The Response of Man to Virulent Shigella flexneri 2a

1969 • 176 citations

Prevention of Shigellosis by a Salmonella typhi-Shigella sonnei Bivalent Vaccine

1987 • 175 citations

Cytokine Production Patterns And Lymphoproliferative Responses In Volunteers Orally Immunized With Attenuated Vaccine Strains Of Salmonella Typhi

1994 • 158 citations

Prospective study of the association between serum antibodies to lipopolysaccharide O antigen and the attack rate of shigellosis

1991 • 158 citations

Shigella enterotoxin 1: an enterotoxin of Shigella flexneri 2a active in rabbit small intestine in vivo and in vitro.

1995 • 155 citations

Mortality Due to Shigellosis: Community and Hospital Data

1991 • 150 citations

Strategy for Cross-Protection amongShigella flexneriSerotypes

1999 • 136 citations

Role of interleukin-1 in the pathogenesis of experimental shigellosis.

1995 • 136 citations

Safety, immunogenicity, and transmissibility in humans of CVD 1203, a live oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virG

1996 • 113 citations

A modified Shigella volunteer challenge model in which the inoculum is administered with bicarbonate buffer: clinical experience and implications for Shigella infectivity

1995 • 111 citations

Engineered deltaguaB-A deltavirG Shigella flexneri 2a strain CVD 1205: construction, safety, immunogenicity, and potential efficacy as a mucosal vaccine

1996 • 102 citations

Studies on vaccination against bacillary dysentery. 6. Protection of children by oral immunization with streptomycin-dependent Shigella strains.

1971 • 98 citations

Studies on vaccination against bacillary dysentery. 4. Oral immunization with live monotypic and combined vaccines.

1968 • 94 citations

Studies on vaccination against bacillary dysentery. 3. Effective oral immunization against Shigella flexneri 2a in a field trial.

1965 • 93 citations

Immunity in Shigellosis. I. Response of Man to Attenuated Strains of Shigella

1972 • 89 citations

Evaluation of the safety, immunogenicity, and efficacy in healthy adults of four doses of live oral hybrid Escherichia coli-Shigella flexneri 2a vaccine strain EcSf2a-2

1995 • 82 citations

Safety, immunogenicity, and efficacy in monkeys and humans of invasive Escherichia coli K-12 hybrid vaccine candidates expressing Shigella flexneri 2a somatic antigen

1992 • 78 citations

Specific immunoglobulin A-secreting cells in peripheral blood of humans following oral immunization with a bivalent Salmonella typhi-Shigella sonnei vaccine or infection by pathogenic S. sonnei

1990 • 74 citations

Identification of A 2‐Md plasmid from shigella flexneri associated with reactive arthritis

1989 • 73 citations

Construction and characterization of attenuated delta aroA delta virG Shigella flexneri 2a strain CVD 1203, a prototype live oral vaccine

1994 • 72 citations

Attenuated ΔguaBA Salmonella typhi Vaccine Strain CVD 915 as a Live Vector Utilizing Prokaryotic or Eukaryotic Expression Systems to Deliver Foreign Antigens and Elicit Immune Responses

1999 • 69 citations

SHIGELLOSIS IN CUSTODIAL INSTITUTIONS1

1970 • 68 citations

Production of IFN-γ and IL-10 to Shigella Invasins by Mononuclear Cells from Volunteers Orally Inoculated with a Shiga Toxin-Deleted Shigella dysenteriae Type 1 Strain

2000 • 68 citations

Natural and recombinant interferons inhibit epithelial cell invasion by Shigella spp

1986 • 68 citations

Safety and immunogenicity study of the auxotrophic Shigella flexneri 2a vaccine SFL1070 with a deleted aroD gene in adult Swedish volunteers

1995 • 57 citations

Age-Specific Prevalence of Serum Antibodies to the Invasion Plasmid and Lipopolysaccharide Antigens of Shigella Species in Chilean and North American Populations

1992 • 54 citations

Construction of an auxotrophic Shigella flexneri strain for use as a live vaccine

1990 • 48 citations

Cloning, Expression, and Affinity Purification of RecombinantShigella flexneriInvasion Plasmid Antigens IpaB and IpaC

1996 • 40 citations

Studies on vaccination against bacillary dysentery. 2. Safety tests and reactogenicity studies on a live dysentery vaccine intended for use in field trials.

1965 • 34 citations

SHIGELLOSIS IN CUSTODIAL INSTITUTIONS1

1972 • 34 citations

Evaluation of transport methods for isolating Shigella spp

1981 • 32 citations

Altered antigen-presenting capacity of human monocytes after phagocytosis of bacteria

1994 • 27 citations

Studies on vaccination against bacillary dysentery. 1. Immunization of mice against experimental Shigella infection.

1965 • 21 citations

Structural Analysis of Invasion Plasmid Antigen D (Ipad) from Shigella flexneri

1995 • 20 citations

Uptake of pathogenic intracellular bacteria into human and murine macrophages downregulates the eukaryotic 26S protease complex ATPase gene

1997 • 6 citations

Mechanisms for Establishing Persistence: Immune Modulation

2014 • 1 citations