Green Fluorescent Protein-Glucocorticoid Receptor Knockin Mice Reveal Dynamic Receptor Modulation During Thymocyte Development

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

1996 • 1,124 citations

Glucocorticoids in T Cell Development and Function

2000 • 783 citations

Murine FGFR-1 is required for early postimplantation growth and axial organization.

1994 • 748 citations

Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation

2000 • 351 citations

Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic.

1990 • 319 citations

CD3ε-mediated signals rescue the development of CD4⁺CD8⁺ thymocytes in RAG-2^−/− mice in the absence of TCR β chain expression

1994 • 205 citations

Mice with an Increased Glucocorticoid Receptor Gene Dosage Show Enhanced Resistance to Stress and Endotoxic Shock

2000 • 202 citations

A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development

1995 • 190 citations

Steroid sensitivity of thymocyte subpopulations during intrathymic differentiation. Effects of 17 beta-estradiol and dexamethasone on subsets expressing T cell antigen receptor or IL-2 receptor.

1989 • 173 citations

RAG2:GFP Knockin Mice Reveal Novel Aspects of RAG2 Expression in Primary and Peripheral Lymphoid Tissues

1999 • 167 citations

Glucocorticoid-induced apoptosis in the thymus.

1992 • 167 citations

Thymus-derived Glucocorticoids Regulate Antigen-specific Positive Selection

1997 • 139 citations

Molecular and Cellular Events in Early Thymocyte Development 11Received for publication October 14, 1997

1998 • 137 citations

Thymocyte apoptosis induced by elevated endogenous corticosterone levels

1994 • 126 citations

Maturation of the Circadian Rhythm of Plasma Corticosterone in the Rat

1967 • 126 citations

Glucocorticoid Receptors Are Differentially Expressed in the Cells and Tissues of the Immune System

1998 • 125 citations

Glucocorticoids Attenuate T Cell Receptor Signaling

2001 • 119 citations

Intrathymic T Cell Development and Selection Proceeds Normally in the Absence of Glucocorticoid Receptor Signaling

2000 • 117 citations

Expression of the mouse corticotropin-releasing hormone gene in vivo and targeted inactivation in embryonic stem cells.

1994 • 115 citations

Thymus-Derived Glucocorticoids Set the Thresholds for Thymocyte Selection by Inhibiting TCR-Mediated Thymocyte Activation

1999 • 106 citations

Adrenal steroid receptor binding in spleen and thymus after stress or dexamethasone.

1990 • 89 citations

THE INFLUENCE OF THE SUPRARENAL GLAND ON THE THYMUS

1924 • 86 citations

CD4+CD8+TCRlow thymocytes express low levels of glucocorticoid receptors while being sensitive to glucocorticoid-induced apoptosis

2001 • 78 citations

Corticotropin-releasing hormone links pituitary adrenocorticotropin gene expression and release during adrenal insufficiency

2000 • 77 citations

Disruption of hypothalamic-pituitary-adrenocortical system in transgenic mice expressing type II glucocorticoid receptor antisense ribonucleic acid permanently impairs T cell function: effects on T cell trafficking and T cell responsiveness during postnatal development.

1995 • 75 citations

Thymocyte Glucocorticoid Resistance Alters Positive Selection and Inhibits Autoimmunity and Lymphoproliferative Disease in MRL-Mice

1998 • 66 citations

Thymocyte Resistance to Glucocorticoids Leads to Antigen-Specific Unresponsiveness Due to “Holes” in the T Cell Repertoire

2000 • 64 citations

Stress-free T-cell development: glucocorticoids are not obligatory

2000 • 51 citations

Glucocorticoids and lymphocytes. II. Cell cycle-dependent changes in glucocorticoid receptor content.

1980 • 50 citations

A New Mouse Gene, SRG3, Related to the SWI3 of Saccharomyces cerevisiae, Is Required for Apoptosis Induced by Glucocorticoids in a Thymoma Cell Line

1997 • 48 citations

Glucocorticoid sensitive and resistant cell populations in the mouse thymus

1980 • 44 citations

Notch1 confers a resistance to glucocorticoid-induced apoptosis on developing thymocytes by down-regulating SRG3 expression

2001 • 36 citations

Glucocorticoid receptors in corticosensitive and corticoresistant thymocyte subpopulations

1977 • 36 citations

Peripheral T Cells Become Sensitive to Glucocorticoid- and Stress-Induced Apoptosis in Transgenic Mice Overexpressing SRG3

2001 • 33 citations

Glucocorticoid receptors in mouse spleen cell subpopulations

1979 • 22 citations

Susceptibility and Resistance to Antigen-Induced Apoptosis in the Thymus of Transgenic Mice

1998 • 19 citations

New study fails to find link between MMR and autism

2001 • 1 citations