Negative feedback mechanism suppresses interleukin‐12 production by antigen‐presenting cells interacting with T helper 2 cells

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 • 818 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1994 • 729 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

Cloning and expression of murine IL-12.

1992 • 474 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

Strategies of Anti‐Cytokine Monoclonal Antibody Development: Immunoassay of IL‐10 and IL‐5 in Clinical Samples

1992 • 384 citations

The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells.

1993 • 384 citations

Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production.

1995 • 372 citations

Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon gamma and tumor necrosis factor alpha.

1995 • 348 citations

Constructing polycompetitor cDNAs for quantitative PCR

1993 • 323 citations

Interleukin‐12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (T_h1) but not on T_h2 cells

1993 • 241 citations

Interleukin 12 at the site of disease in tuberculosis.

1994 • 218 citations

Differential cytokine expression in acute and chronic murine graft‐versus‐host‐disease

1993 • 194 citations

Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone.

1994 • 106 citations

Difference in signal transduction pathway for IL-2 and IL-4 production in T helper 1 and T helper 2 cell clones in response to anti-CD3.

1993 • 40 citations

A Vβ.2‐specific superantigen from exogenous mouse mammary tumor virus carried by FM mice

1994 • 30 citations

T cell activation through TCR/-CD3 complex. IL-2 production of T cell clones stimulated with anti-CD3 without cross-linkage.

1992 • 22 citations

Induction of IL-2 receptor expression and proliferation of T cell clones by a novel cytokine(s)

1992 • 12 citations

Differential Requirement for Humoral Factors for IL-2R Expression of Murine T Cell Subsets, Th1, Th2, and CD8Th Clones

1993 • 8 citations