Lamotrigine Update and its Use in Mood Disorders

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1997 • 1,743 citations

Medication Use and the Risk of Stevens–Johnson Syndrome or Toxic Epidermal Necrolysis

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A Double-Blind Placebo-Controlled Study of Lamotrigine Monotherapy in Outpatients With Bipolar I Depression

1999 • 1,056 citations

Relapse and impairment in bipolar disorder

1995 • 772 citations

A Double-Blind, Placebo-Controlled, Prophylaxis Study of Lamotrigine in Rapid-Cycling Bipolar Disorder

2000 • 492 citations

STRUCTURAL AND FUNCTIONAL STUDIES OF UDP-GLUCURONOSYLTRANSFERASES*

1999 • 491 citations

A Placebo-Controlled Study of Lamotrigine and Gabapentin Monotherapy in Refractory Mood Disorders

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2000 • 399 citations

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The New Antiepileptic Drugs: A Systematic Review of Their Efficacy and Tolerability

1997 • 353 citations

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1999 • 349 citations

Lamotrigine‐Associated Rash: Risk/Benefit Considerations in Adults and Children

1999 • 339 citations

Outcomes of Add‐on Treatment with Lamotrigine in Partial Epilepsy

1993 • 339 citations

Comparative Prophylactic Efficacy of Lithium, Carbamazepine, and the Combination in Bipolar Disorder

1997 • 313 citations

Lamotrigine in Pregnancy: Pharmacokinetics During Delivery, in the Neonate, and During Lactation

2000 • 292 citations

Differential outcome of pure manic, mixed/cycling, and pure depressive episodes in patients with bipolar illness

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An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

1992 • 281 citations

Positive and negative psychiatric effects of antiepileptic drugs in patients with seizure disorders.

1999 • 264 citations

Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: A record linkage study

1997 • 261 citations

Sodium valproate acutely inhibits lamotrigine metabolism.

1992 • 254 citations

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1994 • 241 citations

The Effects of Phenytoin on Impulsive and Premeditated Aggression

1997 • 229 citations

Safety Review of Adult Clinical Trial Experience with Lamotrigine

1998 • 226 citations

Lamotrigine plasma levels reduced by oral contraceptives

2001 • 214 citations

Double-Blind Comparison of Addition of a Second Mood Stabilizer Versus an Antidepressant to an Initial Mood Stabilizer for Treatment of Patients With Bipolar Depression

2000 • 209 citations

Lamotrigine inhibits Ca2+ currents in cortical neurons: functional implications

1996 • 204 citations

Differential Outcome of Pure Manic, Mixed/Cycling, and Pure Depressive Episodes in Patients With Bipolar Illness

1986 • 172 citations

Olanzapine compared to lithium in mania: a double-blind randomized controlled trial

1999 • 170 citations

Spectrum of Activity of Lamotrigine in Treatment-Refractory Bipolar Disorder

1999 • 170 citations

The Anticonvulsant Lamotrigine in Treatment-Resistant Manic-Depressive Illness

1997 • 159 citations

The anticonvulsant, lamotrigine decreases spontaneous glutamate release but increases spontaneous GABA release in the rat entorhinal cortex in vitro

2000 • 158 citations

Placebos, Drug Effects, and Study Design: A Clinician’s Guide

1999 • 151 citations

Safety of Long‐Term Lamotrigine in Epilepsy

1997 • 147 citations

The efficacy of lamotrigine in rapid cycling and non–rapid cycling patients with bipolar disorder

1999 • 145 citations

Lamotrigine and therapeutic drug monitoring: retrospective survey following the introduction of a routine service

1998 • 137 citations

Population pharmacokinetics of lamotrigine monotherapy in patients with epilepsy: retrospective analysis of routine monitoring data

1997 • 134 citations

Factors Influencing the Incidence of Lamotrigine-Related Skin Rash

1999 • 131 citations

Cellular and Molecular Actions of Lamotrigine: Possible Mechanisms of Efficacy in Bipolar Disorder

1998 • 130 citations

Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats

1998 • 128 citations

Bidirectional interaction of valproate and lamotrigine in healthy subjects*

1996 • 123 citations

Lamotrigine in Rapid-Cycling Bipolar Disorder

1997 • 120 citations

An open study of lamotrigine in refractory bipolar depression

1997 • 118 citations

Lamotrigine: Pharmacokinetics

1997 • 115 citations

Lamotrigine compared with lithium in mania: a double-blind randomized controlled trial.

2000 • 108 citations

Aggressive Behaviour in Intellectually Challenged Patients with Epilepsy Treated with Lamotrigine

1998 • 106 citations

A double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy with health-related quality of life as an outcome measure

2000 • 100 citations

Serum Concentrations of Lamotrigine in Epileptic Patients: The Influence of Dose and Comedication

1996 • 100 citations

Lamotrigine toxicity secondary to sertraline

1998 • 96 citations

Adding valproate to lamotrigine: A study of their pharmacokinetic interaction

2000 • 95 citations

Lamotrigine Compared with Lithium in Mania: A Double-Blind Randomized Controlled Trial

2000 • 88 citations

The Influence of Dosage, Age, and Comedication on Steady State Plasma Lamotrigine Concentrations in Epileptic Children

1997 • 86 citations

Adding Lamotrigine to Valproate: Incidence of Rash and Other Adverse Effects

1999 • 85 citations

Lamotrigine inhibition of glutamate release from isolated cerebrocortical nerve terminals (synaptosomes) by suppression of voltage-activated calcium channel activity

2001 • 84 citations

Addition of Lamotrigine to Valproate May Enhance Efficacy in the Treatment of Bipolar Affective Disorder

1996 • 81 citations

Positive and Negative Psychotropic Effects of Lamotrigine in Patients with Epilepsy and Mental Retardation

1998 • 78 citations

Effects of lamotrigine on nocturnal sleep, daytime somnolence and cognitive functions in focal epilepsy

2000 • 76 citations

Effects of rifampicin and cimetidine on pharmacokinetics and pharmacodynamics of lamotrigine in healthy subjects

2000 • 75 citations

Lamotrigine Associated with Insomnia

1999 • 74 citations

Lamotrigine Treatment of Refractory Bipolar Disorder

1997 • 70 citations

Pharmacokinetics of lamotrigine in patients with renal impairment: influence of haemodialysis.

1993 • 65 citations

Lamotrigine for the treatment of bipolar disorder: a clinical case series

1999 • 64 citations

Clinical Studies on the Use of Lamotrigine in Bipolar Disorder

1998 • 63 citations

Glucuronidation of drugs by hepatic microsomes derived from healthy and cirrhotic human livers.

1999 • 63 citations

Stable weight during lamotrigine therapy: A review of 32 studies

2000 • 61 citations

Comparison of the pharmacokinetics of lamotrigine in patients with chronic renal failure and healthy volunteers

1997 • 58 citations

Population Pharmacokinetics of Lamotrigine Adjunctive Therapy in Adults with Epilepsy

1999 • 57 citations

Effect of lamotrigine on the electrically-evoked release of endogenous amino acids from slices of dorsal horn of the rat spinal cord

1995 • 56 citations

Acute granulomatous interstitial nephritis and colitis in anticonvulsant hypersensitivity syndrome associated with lamotrigine treatment

2000 • 53 citations

The efficacy and use of anticonvulsants in mood disorders.

1998 • 52 citations

Treatment of Bipolar Depression, a Review of the Literature and a Suggestion for an Algorithm

2000 • 51 citations

Lamotrigine add-on therapy in focal epilepsy: electroencephalographic and neuropsychological evaluation.

1998 • 45 citations

Clinical Study of Lamotrigine and Valproic Acid in Patients With Epilepsy: Using a Drug Interaction to Advantage?

2000 • 44 citations

Lamotrigine in the Treatment of Schizoaffective Disorder

1998 • 43 citations

Lamotrigine Drug Interactions in a TDM Material

1999 • 41 citations

An open longitudinal study of patients with bipolar rapid cycling treated with lithium or lamotrigine for mood stabilization

2000 • 40 citations

Stimulating consciousness and cognition following severe brain injury: a new potential clinical use for lamotrigine

2000 • 40 citations

Behavioral and Cognitive Effects of Lamotrigine

1997 • 38 citations

Successful re-introduction of lamotrigine after initial rash

2000 • 38 citations

Comparison of the pharmacokinetics of lamotrigine in patients with chronic renal failure and healthy volunteers

1997 • 36 citations

Acute hepatitis after lamotrigine administration.

2000 • 32 citations

Lamotrigine

1995 • 32 citations

Cost Minimization Analysis of Antiepileptic Drugs in Newly Diagnosed Epilepsy in 12 European Countries

2000 • 31 citations

Adjunctive Lamotrigine Treatment for Major Depression

1999 • 31 citations

Lamotrigine inhibits depolarization-evoked Ca++ influx in dissociated amygdala neurons

1998 • 28 citations

Lamotrigine in the treatment of resistant bipolar disorder.

1998 • 27 citations

A review of anticonvulsants in treating agitated demented elderly patients.

1998 • 24 citations

Rectal Absorption of Lamotrigine Compressed Tablets

2000 • 22 citations

A Review of Anticonvulsants in Treating Agitated Demented Elderly Patients

1998 • 21 citations

Exacerbation of Psoriasis during Lithium Treatment

1989 • 19 citations

Implications of the cAMP Signaling Pathway in Psychiatric Disorders: A Systematic Review of the Evidence

2001 • 9 citations

Aggression as an adverse drug reaction.

2000 • 7 citations

P.1.082 Lamotrigine: An alternative drug in the prophylaxis of bipolar disorders

1997 • 6 citations

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