Should We Use N -Acetyltransferase Type 2 Genotyping To Personalize Isoniazid Doses?

Genetic Control of Isoniazid Metabolism in Man

1960 • 792 citations

Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.

2000 • 671 citations

N-acetylation pharmacogenetics.

1985 • 637 citations

Polymorphism of theN-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis

2002 • 423 citations

Molecular mechanism of slow acetylation of drugs and carcinogens in humans.

1991 • 355 citations

Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity.

1995 • 335 citations

Human acetyltransferase polymorphisms

1997 • 267 citations

Slow N-acetyltransferase 2 genotype affects the incidence of isoniazid and rifampicin-induced hepatotoxicity.

2000 • 250 citations

N-acetyltransferase

1989 • 237 citations

Management of tuberculosis : a guide for low income countries

2000 • 209 citations

Genetically Determined Variability in Acetylation and Oxidation Therapeutic Implications

1985 • 197 citations

Low Isoniazid Concentrations and Outcome of Tuberculosis Treatment with Once-Weekly Isoniazid and Rifapentine

2003 • 193 citations

Trimodality of isoniazid elimination: phenotype and genotype in patients with tuberculosis.

1997 • 191 citations

Preliminary phenotypic map of chromosome 4p16 based on 4p deletions

1995 • 177 citations

Isoniazid Pharmacokinetics-Pharmacodynamics in an Aerosol Infection Model of Tuberculosis

2004 • 158 citations

Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms

2001 • 139 citations

DRUG RESISTANCE IN MYCOBACTERIA

1984 • 134 citations

Variations between individuals and populations in the acetylation of isoniazid and its significance for the treatment of pulmonary tuberculosis

1976 • 134 citations

The Early Bactericidal Activity of Isoniazid Related to Its Dose Size in Pulmonary Tuberculosis

1997 • 124 citations

The Influence of Human N-Acetyltransferase Genotype on the Early Bactericidal Activity of Isoniazid

2004 • 87 citations

Novel Human N-Acetyltransferase 2 Alleles That Differ in Mechanism for Slow Acetylator Phenotype

1999 • 75 citations

Pitfalls in N-acetyltransferase 2 genotyping

1999 • 68 citations

Genotyping of the N-acetyltransferase2 Polymorphism in the Prediction of Adverse Drug Reactions to Isoniazid in Japanese Patients

2002 • 65 citations

Genetically determined differences in drug metabolism as a risk factor in drug toxicity

1992 • 53 citations

N-Acetyltransferase2 Genotype Correlated with Isoniazid Acetylation in Japanese Tuberculous Patients.

2001 • 51 citations

Population screening for isoniazid acetylator phenotype

2001 • 36 citations

Comparison of the isoniazid inactivation in Finns and Lapps.

1968 • 13 citations

Conceptions of Right and Wrong

1949 • 12 citations

Pharmacogenetics and its clinical implications: N-acetylation polymorphism.

1987 • 7 citations

New antiarrhythmic agents: mexiletine, tocainide, encainide, flecainide, and amiodarone.

1987 • 3 citations