Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms

Genomic sequencing.

1984 • 8,343 citations

Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.

2000 • 671 citations

N-acetylation pharmacogenetics.

1985 • 637 citations

Molecular mechanism of slow acetylation of drugs and carcinogens in humans.

1991 • 355 citations

Single-nucleotide polymorphisms can cause different structural folds of mRNA

1999 • 313 citations

Human acetyltransferase polymorphisms

1997 • 267 citations

Enhanced proteolysis of thiopurine S -methyltransferase (TPMT) encoded by mutant alleles in humans ( TPMT ∗ 3 A , TPMT ∗ 2 ): Mechanisms for the genetic polymorphism of TPMT activity

1997 • 265 citations

Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes.

1991 • 248 citations

Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 Asians, blacks, Hispanics, and whites: application to metabolic epidemiology.

1993 • 209 citations

Correlation between acetylator phenotypes and genotypes of polymorphic arylamine N-acetyltransferase in human liver.

1990 • 182 citations

Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions.

1995 • 128 citations

Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver.

1990 • 122 citations

Distribution and concordance of N-acetyltransferase genotype and phenotype in an American population.

1999 • 119 citations

Molecular genetics of human polymorphic N-acetyltransferase: enzymatic analysis of 15 recombinant wild-type, mutant, and chimeric NAT2 allozymes

1994 • 118 citations

Sequences and expression of alleles of polymorphic arylamine N-acetyltransferase of human liver.

1992 • 93 citations

Suggestions for the nomenclature of human alleles: relevance to ecogenetics, pharmacogenetics and molecular epidemiology

2000 • 93 citations

N-acetyltransferases: Pharmacogenetics and clinical consequences of polymorphic drug metabolism

1996 • 81 citations

Novel Human N-Acetyltransferase 2 Alleles That Differ in Mechanism for Slow Acetylator Phenotype

1999 • 75 citations

Enzyme kinetic properties of human recombinant arylamine n-acetyltransferase 2 allotypic variants expressed in Escherichia coli

1995 • 56 citations

Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype

2000 • 56 citations

Structure-function studies of human arylamine N-acetyltransferases NAT1 and NAT2. Functional analysis of recombinant NAT1/NAT2 chimeras expressed in Escherichia coli.

1994 • 53 citations

Prostate-specific human N-acetyltransferase 2 (NAT2) expression in the mouse.

1999 • 52 citations

Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles.

1994 • 38 citations

Post-transcriptional regulation of human microsomal epoxide hydrolase

1998 • 38 citations

NAT2*12A (803A???G) codes for rapid arylamine N-acetylatioii in humans

1996 • 37 citations

The Structure and Characteristics of a Fourth Allele of Polymorphic N-Acetyltransferase Gene Found in the Japanese Population

1993 • 27 citations

NAT2 polymorphism associated with plasma glucose concentration in Canadian Oji-Cree

2000 • 18 citations

N-Acetyltransferase-2 polymorphism, smoking and type 1 diabetic nephropathy

1999 • 10 citations