Interaction between the Adhesion Receptor, CD44, and the Oncogene Product, p185 , Promotes Human Ovarian Tumor Cell Activation

Hyaluronan ¹

1992 • 1,787 citations

CD44 and Its Interaction with Extracellular Matrix

1993 • 1,082 citations

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.

1992 • 1,040 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer.

1990 • 763 citations

CD44: The hyaluronan receptor

1992 • 610 citations

Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin.

1992 • 542 citations

Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development

1989 • 487 citations

Characterization of the class III collagen receptor, a phosphorylated, transmembrane glycoprotein expressed in nucleated human cells.

1988 • 382 citations

CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines.

1991 • 347 citations

Neu and its ligands: From an oncogene to neural factors

1993 • 286 citations

Expression of CD44R1 adhesion molecule in colon carcinomas and metastases

1993 • 284 citations

Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A.

1993 • 261 citations

Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function.

1994 • 249 citations

Binding of ovarian cancer cells to peritoneal mesothelium in vitro is partly mediated by CD44H.

1993 • 210 citations

Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction.

1993 • 170 citations

Strong correlation between c-erbB-2 overexpression and overall survival of patients with oral squamous cell carcinoma.

1997 • 155 citations

Tumor invasion: A consequence of destructive and compositional matrix alterations

1988 • 146 citations

New CD44 splice variants associated with human breast cancers

1995 • 136 citations

Post-translational protein modification and expression of ankyrin-binding site(s) in GP85 (Pgp-1/CD44) and its biosynthetic precursors during T-lymphoma membrane biosynthesis.

1991 • 134 citations

The Cell Adhesion Molecule, GP116, Is a New CD44 Variant (ex14/v10) Involved in Hyaluronic Acid Binding and Endothelial Cell Proliferation

1996 • 120 citations

Lymphoma protein kinase C is associated with the transmembrane glycoprotein, GP85, and may function in GP85-ankyrin binding

1989 • 120 citations

Epidemiology and etiology of ovarian cancer.

1991 • 112 citations

Acylation of the lymphoma transmembrane glycoprotein, GP85, may be required for GP85-ankyrin interaction

1991 • 98 citations

The lymphoma transmembrane glycoprotein GP85 (CD44) is a novel guanine nucleotide-binding protein which regulates GP85 (CD44)-ankyrin interaction.

1992 • 89 citations

Mechanisms of c-erbB2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 E1A gene products.

1992 • 85 citations

N-terminal and central regions of the human CD44 extracellular domain participate in cell surface hyaluronan binding.

1995 • 76 citations

A cysteine residue located in the transmembrane domain of CD44 is important in binding of CD44 to hyaluronic acid.

1996 • 73 citations

Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor-independent breast carcinoma cells with c-erbB-2 gene amplification.

1996 • 72 citations

Aberrant expression of the c-erbB-2/neu protooncogene in ovarian cancer

1992 • 69 citations

Hyaluronan-binding protein in endothelial cell morphogenesis.

1992 • 61 citations

Involvement of CD44 and its variant isoforms in membrane-cytoskeleton interaction, cell adhesion and tumor metastasis

1995 • 56 citations

Functional heterogeneity of CD44 molecules in ovarian cancer cell lines.

1995 • 42 citations

Chapter 14 Interactions between the Membrane-Cytoskeleton and CD44 during Lymphocyte Signal Transduction and Cell Adhesion

1996 • 28 citations

Ligand-independent dimerization of oncogenic v-erbB products involves covalent interactions

1996 • 26 citations

Overexpression of CD44 in pl85(neu)-transfected NIH3T3 cells promotes an up-regulation of hyaluronic acid-mediated membrane-cytoskeleton interaction and cell adhesion.

1996 • 25 citations