Has the outlook improved for amifostine as a clinical radioprotector?

Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatin-induced toxicities: results of a randomized control trial in patients with advanced ovarian cancer.

1996 • 455 citations

American Society of Clinical Oncology Clinical Practice Guidelinesfor the Use of Chemotherapy and Radiotherapy Protectants

1999 • 337 citations

Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphosphorothioic acid.

1980 • 300 citations

Differential Chemoprotection of Normal and Malignant Tissues<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1969 • 266 citations

Selective cytoprotection with amifostine in concurrent radiochemotherapy for head and neck cancer

1998 • 182 citations

Radiation apoptosis of serous acinar cells of salivary and lacrimal glands

1991 • 178 citations

Alkaline Phosphatase Promotes Radioprotection and Accumulation of WR-1065 in V79-171 Cells Incubated in Medium Containing WR-2721

1985 • 168 citations

Radioprotection of tumor and normal tissues by thiophosphate compounds

1973 • 136 citations

Use of radiation with or without WR-2721 in advanced rectal cancer

1992 • 134 citations

Target cell and mode of radiation injury in rhesus salivary glands

1986 • 124 citations

Preliminary results of a pilot study using WR-2721 before fractionated irradiation of the head and neck to reduce salivary gland dysfunction

1994 • 111 citations

The sulfhydryl containing compounds WR-2721 and glutathione as radio- and chemoprotective agents. A review, indications for use and prospects

1999 • 110 citations

A randomized study of very accelerated radiotherapy with and without amifostine in head and neck squamous cell carcinoma

2000 • 103 citations

Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (Ethyol): preclinical aspects.

1994 • 96 citations

Amifostine and radiation therapy: past, present, and future.

1996 • 93 citations

Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug Ethyol (WR-2721), protect DNA against fast neutroninduced strand breakage

1997 • 92 citations

Amifostine: the preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies.

1996 • 92 citations

Protective effects of S-2-(3-aminopropylamino)ethylphosphorothioic acid against radiation damage of normal tissues and a fibrosarcoma in mice.

1982 • 90 citations

Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721

1984 • 90 citations

Salivary gland protection by amifostine in high-dose radioiodine treatment: results of a double-blind placebo-controlled study.

1998 • 87 citations

The modification of melphalan toxicity in tumor bearing mice by S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR2721)

1982 • 74 citations

Radioprotection of Normal Tissues against Gamma Rays and Cyclotron Neutrons with WR-2721: LD 50 Studies and 35 S-WR-2721 Biodistribution

1984 • 73 citations

Radioprotection by WR-2721 in vitro at low oxygen tensions: Implications for its mechanisms of action

1983 • 70 citations

Prediction of the Effective Radioprotective Dose of WR-2721 in Humans through an Interspecies Tissue Distribution Study

1976 • 68 citations

Time dependence of the selective modulation of cisplatin-induced nephrotoxicity by WR2721 in the mouse.

1992 • 67 citations

Combined Use of Radioprotective and Radiosensitizing Drugs in Experimental Radiotherapy

1977 • 62 citations

Radiotherapy of Experimental Lung Tumors in the Presence and Absence of a Radioprotective Drug, S-2-(3-aminopropylamino)ethylphosphorothioic Acid (WR-2721)2

1973 • 61 citations

Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice

1994 • 59 citations

A trial of Ro 03-8799 (pimonidazole) in carcinoma of the uterine cervix: an interim report from the Medical Research Council Working Party on advanced carcinoma of the cervix

1993 • 59 citations

Radioprotective effects of amifostine.

1999 • 56 citations

Protection of Normal Tissues from the Cytotoxic Effects of Chemotherapy and Radiation by Amifostine (WR-2721): Preclinical Aspects

1995 • 54 citations

Radiobiology for the Radiologist. 5th ed.

2002 • 51 citations

The oxygen dependence of protection by aminothiols: Implications for normal tissues and solid tumors

1984 • 50 citations

Radioprotection of mouse skin by WR-2721: The critical influence of oxygen tension

1982 • 49 citations

Protection of Normal Tissue from the Cytotoxic Effects of Chemotherapy and Radiation by Amifostine: Clinical Experiences

1995 • 46 citations

Clinical status and optimal use of amifostine.

1999 • 46 citations

Effect of tumor type, size, and endpoint on tumor radioprotection by WR-2721

1984 • 44 citations

Pharmacokinetic profile of amifostine.

1996 • 44 citations

Influence of wr 2721 on radiation response of canine soft tissue sarcomas

1986 • 43 citations

Differential Radioprotection of Euoxic and Hypoxic Mouse Mammary Tumors by a Thiophosphate Compound

1974 • 42 citations

Design and interpretation of clinical trials that evaluate agents that may offer protection from the toxic effects of cancer chemotherapy.

1998 • 42 citations

Radioprotection of salivary glands by S-2-(3-aminopropylamino)-ethylphosphorothioic (amifostine) obtained in a rabbit animal model

1999 • 38 citations

Dephosphorylation of WR-2721 with mouse tissue homogenates

1984 • 38 citations

Protective drugs in cancer therapy: Optimal clinical testing and future directions

1982 • 38 citations

Fractionation studies with WR-2721: Normal tissues and tumour

1986 • 36 citations

Radiotherapeutic studies with amifostine (Ethyol).

1994 • 32 citations

Protective effects of WR-2721 against radiation-induced injury of murine gut, testis, lung, and lung tumor nodules

1982 • 29 citations

Tumor blood flow changes induced by chemical modifiers of radiation response

1992 • 28 citations

Efficacy testing of WR-2721 in Great Britain or everything is black and white at the gray lab

1983 • 26 citations

Effect of Radioprotective Drugs on the Therapeutic Ratio for a Mouse Tumor System

1973 • 25 citations

Influence of WR 2721 on the efficacy of radiotherapy and chemotherapy of murine tumors

1982 • 25 citations

Radiosensitisation and radioprotection by BSO and WR-2721: the role of oxygenation

1989 • 23 citations

Modification by WR 2721 of the response to chemotherapy of tumours and normal tissues in the mouse

1983 • 23 citations

The Effect of S-2-(3-Aminopropylamino)ethylphosphorothioic Acid (WR-2721) on Intestinal Crypt Survival: II. Fission Neutrons

1976 • 23 citations

Clinical study of radioprotective effects of amifostine (YM-08310, WR-2721) on long-term outcome for patients with cervical cancer

1993 • 22 citations

Variation in normal tissue responsiveness to WR-2721

1984 • 21 citations

Experimental radiotherapy with WR-2721 and misonidazole

1982 • 20 citations

The influence of X ray dose levels on normal tissue radioprotection by WR-2721

1984 • 19 citations

Interaction of misonidazole and WR-2721—II. Modification of tumour radiosensitization

1983 • 17 citations

Radioprotection of mouse skin vasculature and the RIF-1 fibrosarcoma by WR-2721

1984 • 17 citations

6 Final report of a phase III randomized trial of amifostine as a radioprotectant in head and neck cancer

1999 • 17 citations

Effect of the radioprotective drugs MEA, DMSO, and WR-2721 on tumor control and skin tolerance in the rat.

1977 • 17 citations

Effect of the chemoprotective agent WR-2721 on disposition and biotransformations of ormaplatin in the Fischer 344 rat bearing a fibrosarcoma.

1995 • 12 citations

Comparison of the Protective Effects of Three Phosphorothioate Radioprotectors in the RIF-1 Tumor

1986 • 8 citations

Tumor sensitization and protection: Influence of stromal injury on estimates of dose modification

1984 • 6 citations

Radioprotection combined with hypoxic sensitization during radiotherapy of a solid murine tumor.

1983 • 6 citations

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