Major DNA Fragmentation Is a Late Event in Apoptosis

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Apoptosis, oncosis, and necrosis. An overview of cell death.

1995 • 3,325 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Apoptosis induced by anticancer drugs

1992 • 861 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1992 • 685 citations

Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview

1992 • 600 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).

1993 • 554 citations

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

1985 • 545 citations

A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome

1992 • 523 citations

Taxol: an antimitotic agent with a new mechanism of action

1984 • 483 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Cell nucleus and DNA fragmentation are not required for apoptosis.

1994 • 436 citations

Activation of programmed cell death by anticancer agents: cisplatin as a model system.

1990 • 408 citations

In situ apoptotic cell labeling by the TUNEL method: improvement and evaluation on cell preparations.

1996 • 369 citations

Detection of DNA fragmentation in apoptosis: application of in situ nick translation to cell culture systems and tissue sections.

1993 • 276 citations

Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells.

1993 • 273 citations

The Protein Kinase Inhibitor Staurosporine Induces Morphological Changes Typical of Apoptosis in MOLT-4 Cells without Concomitant DNA Fragmentation

1993 • 181 citations

The toxic plant proteins ricin and abrin induce apoptotic changes in mammalian lymphoid tissues and intestine

1987 • 147 citations

Cytotoxic effects of cell cycle phase specific agents: result of cell cycle perturbation.

1990 • 144 citations

A New Function for an Old Enzyme: The Role of DNase I in Apoptosis

1995 • 107 citations

Morphologic Methods in the Study of Endocytosis in Cultured Cells

1985 • 14 citations