Proteinases, proteolysis and biological control in the yeast Saccharomyces cerevisiae

Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway

1980 • 1,808 citations

Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli

1976 • 1,572 citations

Proteases and biological control

1976 • 1,380 citations

The molecular biology of the yeast saccharomyces: Life cycle and inheritance

1982 • 1,361 citations

DNA Repair in Bacteria and Mammalian Cells

1979 • 854 citations

Order of events in the yeast secretory pathway

1981 • 804 citations

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

1984 • 698 citations

Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells.

1975 • 691 citations

Mechanisms of Intracellular Protein Breakdown

1982 • 647 citations

Post-Translational Proteolysis in Polypeptide Hormone Biosynthesis

1982 • 590 citations

Structure of a yeast pheromone gene (MFα): A putative α-factor precursor contains four tandem copies of mature α-factor

1982 • 587 citations

Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole

1982 • 579 citations

Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85

1984 • 533 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

PROTEINASE MUTANTS OF SACCHAROMYCES CEREVISIAE

1977 • 460 citations

Proteases and biological control

1975 • 412 citations

Glycosylation and processing of prepro-α-factor through the yeast secretory pathway

1984 • 410 citations

Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase

1983 • 403 citations

Carboxypeptidase from Yeast

1973 • 351 citations

Catabolite inactivation in yeast

1976 • 332 citations

Isolation and Genetic Analysis of Saccharomyces cerevisiae Mutants Supersensitive to G1 Arrest by a Factor and α Factor Pheromones

1982 • 322 citations

The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein

1984 • 313 citations

Ubiquitin: Roles in protein modification and breakdown

1983 • 297 citations

Comparative biochemistry of the proteinases of eucaryotic microorganisms

1982 • 276 citations

The vacuole as the lysosome of the yeast cell

1967 • 263 citations

Amino-terminal processing of mutant forms of yeast iso-1-cytochrome c. The specificities of methionine aminopeptidase and acetyltransferase.

1985 • 239 citations

myo-Inositol-1-phosphate synthase. Characteristics of the enzyme and identification of its structural gene in yeast.

1981 • 228 citations

Chitin synthetase zymogen is attached to the yeast plasma membrane.

1975 • 220 citations

Import of proteins into mitochondria. Energy-dependent, two-step processing of the intermembrane space enzyme cytochrome b2 by isolated yeast mitochondria.

1982 • 220 citations

Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.

1982 • 216 citations

Sequence of the preprotoxin dsRNA gene of type I killer yeast: Multiple processing events produce a two-component toxin

1984 • 214 citations

PEP4 GENE FUNCTION IS REQUIRED FOR EXPRESSION OF SEVERAL VACUOLAR HYDROLASES IN SACCHAROMYCES CEREVISIAE

1982 • 211 citations

Vacuoles: The sole compartments of digestive enzymes in yeast (Saccharomyces cerevisiae)?

1979 • 202 citations

Import of proteins into mitochondria. Partial purification of a matrix-located protease involved in cleavage of mitochondrial precursor polypeptides.

1983 • 201 citations

Double-stranded ribonucleic acid killer systems in yeasts

1984 • 201 citations

Mutant defective in processing of an enzyme located in the lysosome-like vacuole of Saccharomyces cerevisiae.

1981 • 199 citations

Repression von alkoholdehydrogenase, malatdehydrogenase, isocitratlyase und malatsynthase in hefe durch glucose

1966 • 197 citations

Recovery of S. cerevisiae a cells from G1 arrest by α factor pheromone requires endopeptidase action

1979 • 193 citations

An MF alpha 1-SUC2 (alpha-factor-invertase) gene fusion for study of protein localization and gene expression in yeast.

1983 • 187 citations

Inactivation of 1,6-Diphosphatase by Glucose in Yeast

1971 • 181 citations

Control of yeast cell type by the mating type locus

1981 • 180 citations

THE SYNTHESIS AND FUNCTION OF PROTEASES IN SACCHAROMYCES: GENETIC APPROACHES

1984 • 179 citations

Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.

1982 • 178 citations

The glucan components of the cell wall of baker's yeast (Saccharomyces cerevisiae) considered in relation to its ultrastructure

1969 • 172 citations

A neutral metallo endoprotease involved in the processing of an F1-ATPase subunit precursor in mitochondria.

1982 • 167 citations

Biosynthesis of the Vacuolar Yeast Glycoprotein Carboxypeptidase Y

1978 • 164 citations

The secreted form of invertase in Saccharomyces cerevisiae is synthesized from mRNA encoding a signal sequence.

1983 • 164 citations

Stepwise Cleavage of the Pro Part of Promelittin by Dipeptidylpeptidase IV

1980 • 157 citations

Carbohydrate Moiety of Carboxypeptidase Y and Perturbation of Its Biosynthesis

1978 • 148 citations

Inactivation of yeast fructose-1,6-bisphosphatase. In vivo phosphorylation of the enzyme.

1982 • 148 citations

Turnover of Yeast Fructose-Bisphosphatase in Different Metabolic Conditions

1980 • 147 citations

Regulation of fructose-1,6-bisphosphatase in yeast by phosphorylation/dephosphorylation

1981 • 144 citations

GlycoProtein biosynthesis in yeast. protein conformation affects processing of high mannose oligosaccharides on carboxypeptidase Y and invertase.

1983 • 142 citations

On the Activity and Regulation of Anaplerotic and Gluconeogenetic Enzymes during the Growth Process of Baker's Yeast

1975 • 134 citations

Physiology of Killer Factor in Yeast

1981 • 132 citations

Activities and cellular localization of yeast proteases and their inhibitors

1974 • 132 citations

[48] Carboxypeptidase Y

1976 • 132 citations

Yeast Malate Dehydrogenase: Enzyme Inactivation in Catabolite Repression

1967 • 132 citations

Intracellular protein and nucleic acid turnover in resting yeast cells

1958 • 130 citations

TWO CHROMOSOMAL GENES REQUIRED FOR KILLING EXPRESSION IN KILLER STRAINS OF SACCHAROMYCES CEREVISIAE

1976 • 127 citations

IS THERE SOS INDUCTION IN MAMMALIAN CELLS?

1980 • 121 citations

THE COMPONENTS OF MALTOZYMASE IN YEAST, AND THEIR BEHAVIOR DURING DEADAPTATION

1957 • 121 citations

Presecretory and cytoplasmic invertase polypeptides encoded by distinct mRNAs derived from the same structural gene differ by a signal sequence.

1982 • 120 citations

PROTEIN DEGRADATION, MEIOSIS AND SPORULATION IN PROTEINASE-DEFICIENT MUTANTS OF SACCHAROMYCES CEREVISIAE

1981 • 115 citations

Isolation and partial characterization of an acid carboxypeptidase from yeast

1974 • 114 citations

Hormone processing and membrane-bound proteinases in yeast.

1985 • 114 citations

A deletion that includes the signal peptidase cleavage site impairs processing, glycosylation, and secretion of cell surface yeast acid phosphatase.

1984 • 112 citations

Studies on protein and nucleic acid turnover in growing cultures of yeast

1958 • 110 citations

Comparisons of the Tryptophan Synthase Inactivating Enzymes with Proteinases from Yeast

1974 • 110 citations

Effect of glucose on the activity and the kinetics of the maltose-uptake system and of α-glucosidase in Saccharomycescerevisiae

1969 • 108 citations

Inactivation by glucose of phosphoenolpyruvate carboxykinase from Saccharomyces cerevisiae

1976 • 106 citations

Cyclic AMP-dependent phosphorylation of fructose-1,6-bisphosphatase in yeast

1982 • 103 citations

Import of proteins into mitochondria. Import and maturation of the mitochondrial intermembrane space enzymes cytochrome b2 and cytochrome c peroxidase in intact yeast cells.

1982 • 102 citations

Catabolite inactivation of the galactose uptake system in yeast.

1977 • 100 citations

A chromosomal gene required for killer plasmid expression, mating, and spore maturation in Saccharomyces cerevisiae.

1976 • 99 citations

Isolation of carboxypeptidase Y by affinity chromatography

1976 • 96 citations

Proteolysis in eukaryotic cells. Identification of multiple proteolytic enzymes in yeast.

1984 • 95 citations

In vivo biosynthesis of the vacuolar proteinases A and B in the yeast Saccharomyces cerevisiae.

1982 • 92 citations

The secretory pathway in yeast

1982 • 91 citations

Proteinase C (carboxypeptidase Y) mutant of yeast

1975 • 91 citations

Three yeast proteins that specifically inhibit yeast proteases A, B, and C

1975 • 91 citations

Subcellular localization and levels of aminopeptidases and dipeptidase in Saccharomyces cerevisiae

1978 • 90 citations

The use of endo-β-N-acetylglucosaminidase H in characterizing the structure and function of glycoproteins

1977 • 89 citations

Protein Degradation and Proteinases during Yeast Sporulation

1976 • 89 citations

Immunochemical studies on catabolite inactivation of phosphoenolpyruvate carboxykinase in Saccharomyces cerevisiae.

1981 • 86 citations

The activating system of chitin synthetase from Saccharomyces cerevisiae. Purification and properties of the activating factor.

1976 • 85 citations

Secretion ofSaccharomyces cerevisiaeKiller Toxin: Processing of the Glycosylated Precursor

1983 • 85 citations

Mutations in PEP4 locus of Saccharomyces cerevisiae block final step in maturation of two vacuolar hydrolases.

1983 • 84 citations

Purification and Characterization of Macromolecular Inhibitors of Proteinase A from Yeast

1974 • 84 citations

Purification and properties of proteinase A from yeast.

1980 • 84 citations

Isolation and characterization of aminopeptidase mutants of Saccharomyces cerevisiae

1983 • 83 citations

Carbohydrate chains on yeast carboxypeptidase Y are phosphorylated.

1981 • 82 citations

A novel protease from yeast with specificity towards paired basic residues

1984 • 82 citations

A glycosylated protoxin in killer yeast: Models for its structure and maturation

1983 • 80 citations

Purification of Yeast Proteinases

1967 • 80 citations

Fatty acid biosynthesis in yeast

1978 • 79 citations

Chitin synthetase activating factor from yeast, a protease

1973 • 79 citations

Synthesis and turnover of ribosomal proteins in the absence of 60S subunit assembly in Saccharomyces cerevisiae

1977 • 76 citations

Effects of glucose and nitrogen source on the levels of proteinases, peptidases, and proteinase inhibitors in yeast

1977 • 76 citations

Proteolysis in eukaryotic cells. Proteinase yscE, a new yeast peptidase.

1984 • 76 citations

Septum formation, cell division, and sporulation in mutants of yeast deficient in proteinase B.

1979 • 73 citations

Purification and properties of two proteinases from Saccharomyces cerevisiae

1967 • 68 citations

Studies on a Proteinase B Mutant of Yeast

1979 • 68 citations

Compartmentation of inhibitors of proteinases A and B and carboxypeptidase Y in yeast

1974 • 67 citations

Evidence for an essential histidine in carboxypeptidase Y. Reaction with the chloromethyl ketone derivative of benzyloxycarbonyl-L-phenylalanine.

1975 • 67 citations

Physical and Chemical Properties of Yeast Proteinase C

1971 • 61 citations

Control of Metabolism in Yeast and other Lower Eukaryotes through Action of Proteinases

1981 • 60 citations

New proteolytic enzymes in yeast

1981 • 59 citations

Analysis of Proteinase A Function in Yeast

1981 • 58 citations

Proteinase activities of Saccharomyces cerevisiae during sporulation

1975 • 58 citations

Glucose-dependent metabolic interconversion of fructose-1,6-bisphosphatase in yeast

1981 • 58 citations

A lysosomal aminopeptidase isozyme in differentiating yeast cells and protoplasts

1971 • 57 citations

Purification of Yeast Proteinases

1967 • 57 citations

Genetic control of the SOS system in E. coli

1981 • 56 citations

Yeast proteinase B: Identification of the inactive form as an enzyme-inhibitor complex

1969 • 55 citations

Physical and Chemical Properties of Yeast Proteinase C

1971 • 55 citations

Proteinase action in vitro versus proteinase function in vivo: mutants shed light on intracellular proteolysis in yeast

1982 • 55 citations

Purification and properties of proteinase B from yeast

1981 • 53 citations

Properties of the single sulfhydryl group of carboxypeptidase Y. Effects of alkyl and aromatic mercurials on activities toward various synthetic substrates.

1979 • 52 citations

Inhibition of the Apparent Rate of Synthesis of the Vacuolar Glycoprotein Carboxypeptidase Y and Its Protein Antigen by Tunicamycin in Saccharomyces cerevisiae

1976 • 51 citations

Evidence for Catabolite Degradation in the Glucose‐Dependent Inactivation of Yeast Cytoplamic Malate Dehydrogenase

1978 • 51 citations

Effect of metabolic conditions on protein turnover in yeast

1979 • 51 citations

Localization of the thermosensitive X‐prolyl dipeptidyl aminopeptidase in the vacuolar membrane of Saccharomyces cerevisiae

1984 • 51 citations

Carboxypeptidase S- and Carboxypeptidase Y-Deficient Mutants of Saccharomyces cerevisiae

1981 • 49 citations

Isolation and Characterization of the Carboxypeptidase Y Inhibitor from Yeast

1974 • 49 citations

A new X‐prolyl‐dipeptidyl aminopeptidase from yeast associated with a particulate fraction

1981 • 48 citations

Specific Inactivation of Fructose 1,6‐Bisphosphatase from Saccharomyces cerevisiae by a Yeast Protease

1974 • 48 citations

Über die Proteasen der Hefe. Sechste Abhandlung über pflanzliche Proteasen.

1926 • 48 citations

Control of yeast cell type by the mating type locus

1981 • 46 citations

Invivo biosynthesis of vacuolar proteinases in proteinase mutants of Saccharomycescerevisiae

1982 • 42 citations

Aminopeptidase Co, a new yeast peptidase

1982 • 42 citations

MAPPING OF THE PROTEINASE B STRUCTURAL GENE PRB1, IN SACCHAROMYCES CEREVISIAE AND IDENTIFICATION OF NONSENSE ALLELES WITHIN THE LOCUS

1980 • 41 citations

Import of proteins into mitochondria. Isolated yeast mitochondria and a solubilized matrix protease correctly process cytochrome c oxidase subunit V precursor at the NH2 terminus.

1983 • 40 citations

Hormonal control of gametogenesis in the yeast Saccharomyces cerevisiae

1981 • 40 citations

Activation of chitin synthetase in permeabilized cells of a Saccharomyces cerevisiae mutant lacking proteinase B

1982 • 40 citations

Evidence for the nuclear origin of RNA polymerases identified in the cytosol: Release of enzymes from the nuclei isolated in isotonic sucrose

1976 • 39 citations

Effect of glucose starvation on the nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenase of yeast

1978 • 39 citations

Purification of Yeast Proteinases

1967 • 37 citations

Isolation of yeast mutants lacking proteinase B activity

1978 • 36 citations

Inactivation of Yeast Enzymes by Proteinase A and B and Carboxypeptidase Y from Yeast

1976 • 35 citations

Proteolysis in eucaryotic cells: Aminopeptidases and dipeptidyl aminopeptidases of yeast revisited

1983 • 34 citations

Synthesis and processing of in vitro and in vivo precursors of the vacuolar yeast enzyme carboxypeptidase Y.

1981 • 34 citations

The substrate specificity of proteinase B from Baker's yeast

1981 • 34 citations

Yeast pheromone α-factor is synthesized as a high molecular weight precursor

1983 • 34 citations

Vacuoles are not the sole compartments of proteolytic enzymes in yeast

1984 • 33 citations

Regulation of Saccharomyces cerevisiae nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenase by proteolysis during carbon starvation

1979 • 32 citations

Phosphorylation and proteolysis regulate the NAD‐dependent glutamate dehydrogenase from Saccharomyces cerevisiae

1980 • 32 citations

Aminopeptidases in the acidic fraction of the yeast autolsate.

1975 • 31 citations

Amino acid sequence of carboxypeptidase Y. II. Peptides from enzymatic cleavages

1982 • 31 citations

A unique carboxypeptidase activity of yeast proteinase C

1970 • 30 citations

Carboxypeptidase S from yeast: regulation of its activity during vegetative growth and differentiation

1978 • 29 citations

Purification and molecular characterization of two inhibitors of yeast proteinase B.

1979 • 28 citations

The yeast primary septum: a journey into three-dimensional biochemistry

1976 • 27 citations

Inhibition of protein synthesis stimulates intracellular protein degradation in growing yeast cells

1976 • 26 citations

Studies on the Proteinase-A Inhibitor I^A₃from Yeast

1976 • 25 citations

Natural occurrence and chemical modification of proteinase B inhibitors from yeast.

1977 • 25 citations

External and Internal Forms of Yeast Aminopeptidase II

1979 • 24 citations

Purification of Yeast Proteinases

1967 • 24 citations

Purification and fluorometric assay of proteinase A from yeast

1983 • 24 citations

Proteolytic activities in yeast after UV irradiation

1982 • 22 citations

Purification and Characterization of Yeast Protease B

1980 • 22 citations

Control of Fatty-Acid-Synthetase Biosynthesis in Saccharomyces cerevisiae

1975 • 22 citations

Proteinase yscD. Purification and characterization of a new yeast peptidase.

1985 • 21 citations

The glucose‐induced inactivation of aminopeptidase I in Saccharomyces cerevisiae

1979 • 21 citations

Reactions of yeast carboxypeptidase C with group-specific reagents

1976 • 21 citations

Catabolite inactivation of gluconeogenic enzymes in mutants of yeast deficient in proteinase B.

1979 • 20 citations

Degradation of total cell protein at different stages ofSaccharomyces cerevisiae yeast growth

1976 • 19 citations

Proteolytic inactivation of the NADP-dependent glutamate dehydrogenase in proteinase-deficient mutants of Saccharomyces cerevisiae

1980 • 19 citations

Calculation of half-lives of proteins in vivo. Heterogeneity in the rate of degradation of yeast proteins

1982 • 18 citations

Amino acid sequence of carboxypeptidase Y. I. Peptides from cleavage with cyanogen bromide

1982 • 18 citations

Purification of Yeast Proteinases:Part II. Purification and Some Properties of Yeast Proteinase C

1967 • 17 citations

Measurement of proteinase B activity in crude yeast extracts: A novel procedure of activation using pepsin

1981 • 17 citations

Micro-organisms and Nitrogen Sources: Transport and Utilization of Amino Acids, Peptides, Proteins, and Related Substrates

1981 • 16 citations

Regulation of mitochondrial biogenesis. Occurrence of non-functioning components of the mitochondrial respiratory chain in Saccharomyces cerevisiae grown in the presence of proteinase inhibitors: evidence for proteolytic control over assembly of the respiratory chain

1980 • 16 citations

The immunological detection of yeast nonsense termination fragments on sodium dodecylsulfate-polyacrylamide gels

1978 • 15 citations

Catabolite Inactivation of Bakers'-Yeast Uridine Nucleosidase. Isolation and Partial Purification of a Specific Proteolytic Inactivase

1977 • 15 citations

Bakers' yeast protease a purification and enzymatic and molecular properties

1982 • 15 citations

Proteolytic activities in yeast after UV irradiation

1982 • 14 citations

Microorganisms and nitrogen sources: Transport and utilization of amino acids, peptides, proteins, and related substrates

1980 • 13 citations

The yeast his4 multifunctional protein. Immunochemistry of the wild type protein and altered forms.

1981 • 13 citations

A possible role for a single cysteine residue in carboxypeptidase Y

1975 • 12 citations

The intracellular proteinases and their inhibitors in yeast. A mutant with altered regulation of proteinase A inhibitor activity.

1980 • 11 citations

Detection, isolation and some properties of membrane proteinases from yeast mitochondria

1984 • 10 citations

Characterization of the proteolytic activity firmly attached to yeast phosphoenolpyruvate carboxykinase

1982 • 5 citations