von Willebrand factor contained in a high purity FVIII concentrate (Fanhdi) binds to platelet glycoproteins and supports platelet adhesion to subendothelium under flow conditions.

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

1978 • 4,673 citations

A One-stage Factor VIII (Antihaemophilic Globulin) Assay and its Use on Venous and Capillary Plasma

1962 • 340 citations

Inactivation of human factor VIII by activated protein C. Cofactor activity of protein S and protective effect of von Willebrand factor.

1988 • 244 citations

Platelet adhesion and thrombus formation on subendothelium in platelets deficient in glycoproteins IIb-IIIa, Ib, and storage granules

1986 • 215 citations

Von Willebrand factor in the vessel wall mediates platelet adherence

1985 • 204 citations

The role of von Willebrand factor multimers and propeptide cleavage in binding and stabilization of factor VIII.

1991 • 159 citations

Adhesion of platelets to human artery subendothelium: effect of factor VIII-von Willebrand factor of various multimeric composition

1984 • 135 citations

Comparison of four virus-inactivated plasma concentrates for treatment of severe von Willebrand disease: a cross-over randomized trial

1992 • 115 citations

A sensitive ELISA for von Willebrand factor (vWf:Ag)

1987 • 114 citations

Binding of factor VIII-von Willebrand factor to human arterial subendothelium precedes increased platelet adhesion and enhances platelet spreading.

1981 • 106 citations

Inter‐individual variation in half‐life of infused recombinant factor VIII is related to pre‐infusion von Willebrand factor antigen levels

1995 • 104 citations

[5] Measurements of platelet interaction with components of the vessel wall in flowing blood

1989 • 91 citations

Antihemophilic factor concentrate therapy in von Willebrand disease. Dissociation of bleeding-time factor and ristocetin-cofactor activities.

1976 • 90 citations

Characteristics of Various Factor VIII Concentrates used in Treatment of Haemophilia A

1977 • 84 citations

Replacement Therapy with Virus—Inactivated Plasma Concentrates in von Willebrand Disease

1992 • 76 citations

Luminography – an Alternative Assay for Detection of von Willebrand Factor Multimers

1988 • 75 citations

Epinephrine reverses the inhibitory influence of aspirin on platelet-vessel wall interactions

1986 • 71 citations

Development of a Computer Program to Analyze the Parameters of Platelet-Vessel Wall Interaction

1986 • 67 citations

Further Evidence that Glycoprotein IIb-IIIa Mediates Platelet Spreading on Subendothelium

1991 • 58 citations

A method for measuring plasma ristocetin cofactor activity—normal distribution and stability during storage

1978 • 53 citations

Correction of the bleeding time in treated patients with severe von willebrand disease is not solely dependent on the normal multimeric structure of plasma von willebrand factor

1987 • 51 citations

Therapy of von Willebrand Disease

1993 • 48 citations

The use of intermediate and high purity factor VIII products in the treatment of von Willebrand disease.

1994 • 40 citations

Comparison of the in vitro characteristics of von Willebrand factor in British and commercial factor VIII concentrates

1989 • 36 citations

Interaction of platelets with subendothelium in humans treated with aspirin and dipyridamole alone or in combination

1985 • 34 citations

The role of the Baumgartner technique in transfusion medicine: research and clinical applications

1994 • 32 citations

Characterization of von willebrand factor in factor VIII concentrates

1989 • 29 citations

Ex Vivo Models for Studying Thrombosis: Special Emphasis on Shear Rate Dependent Blood-Collagen Interactions

1992 • 26 citations

In vitro and in vivo characterization of a high‐purity, solvent/detergent‐treated factor VIII concentrate: Evidence for its therapeutic efficacy in von Willebrand's disease

1989 • 24 citations

Role for platelet von willebrand factor in supporting platelet‐vessel wall interactions in von willebrand disease

1989 • 19 citations

FACTOR VIII RELATED ACTIVITIES IN CONCENTRATES

1984 • 13 citations

Comparison between Human Umbilical Artery and Rabbit Abdominal Aorta as Substrata for Platelet Adhesion and Platelet Thrombus Formation under Flow Conditions

1991 • 10 citations

An intermediate‐purity factor VIII concentrate supports platelet adhesion under flow conditions

1997 • 6 citations

von Willebrand factor contained in factor VIII concentrates of different purities supports platelet adhesion in blood samples from a heterogeneous group of patients with von Willebrand disease.

1998 • 5 citations