Sex Differences in Hepatic Heme Oxygenase Expression and Activity Following Trauma and Hemorrhagic Shock

The Protective Effects of Estrogen on the Cardiovascular System

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Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

2000 • 2,074 citations

The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.

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Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

1989 • 1,273 citations

Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis

2000 • 970 citations

Stress–inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection

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Heme Oxygenase-1

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EFFECT OF GENDER AND SEX HORMONES ON IMMUNE RESPONSES FOLLOWING SHOCK

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Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver.

1995 • 388 citations

Male Gender Is a Risk Factor for Major Infections After Surgery

1999 • 338 citations

Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation.

1998 • 269 citations

Heme Oxygenase-1: Redox Regulation and Role in the Hepatic Response to Oxidative Stress

2002 • 253 citations

Ex vivoexposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway

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Expression pattern of heme oxygenase isoenzymes 1 and 2 in normal and stress-exposed rat liver

1998 • 176 citations

Organ dysfunction following hemorrhage and sepsis: mechanisms and therapeutic approaches (Review).

1999 • 172 citations

Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats.

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Role of Bilirubin as an Antioxidant in an Ischemia–Reperfusion of Rat Liver and Induction of Heme Oxygenase

1996 • 160 citations

The heme oxygenase system and its functions in the brain.

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Heme oxygenase‐1 in growth control and its clinical application to vascular disease

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Estradiol Administration After Trauma-Hemorrhage Improves Cardiovascular and Hepatocellular Functions in Male Animals

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Carbon Monoxide as an Endogenous Modulator of Hepatic Vascular Perfusion

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Protective role of heme oxygenase-1 on trinitrobenzene sulfonic acid-induced colitis in rats

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Testosterone and/or Low Estradiol

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Purification and characterization of cytokine-induced neutrophil chemoattractant produced by epithelioid cell line of normal rat kidney (NRK-52E cell)

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Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia

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The female reproductive cycle is an important variable in the response to trauma-hemorrhage

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Vessel- and target cell-specific actions of endothelin-1 and endothelin-3 in rat liver

1995 • 122 citations

Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature

1997 • 119 citations

Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males

1997 • 113 citations

Heat Shock Response - Pathophysiological Implications

1997 • 103 citations

MICROCIRCULATORY FAILURE DETERMINES LETHAL HEPATOCYTE INJURY IN ISCHEMIC/REPERFUSED RAT LIVERS

1994 • 103 citations

Testosterone: The Crucial Hormone Responsible for Depressing Myocardial Function in Males After Trauma-Hemorrhage

1998 • 94 citations

Differential expression pattern of heme oxygenase-1/heat shock protein 32 and nitric oxide synthase-II and their impact on liver injury in a rat model of hemorrhage and resuscitation

1999 • 93 citations

17-Beta-estradiol protects the liver against warm ischemia/reperfusion injury and is associated with increased serum nitric oxide and decreased tumor necrosis factor-alpha

2002 • 93 citations

Estradiol Administration Improves Splanchnic Perfusion Following Trauma-Hemorrhage and Sepsis

2002 • 89 citations

Insight into the mechanism by which estradiol improves organ functions after trauma-hemorrhage

2000 • 86 citations

Selected Contribution: Effects of gender on reduced-size liver ischemia and reperfusion injury

2001 • 84 citations

Bilirubin Is Oxidized in Rats Treated with Endotoxin and Acts as a Physiological Antioxidant Synergistically with Ascorbic Acid in Vivo

1995 • 76 citations

Crystalloid resuscitation restores but does not maintain cardiac output following severe hemorrhage

1991 • 75 citations

Role of nitric oxide in porcine liver circulation under normal and endotoxemic conditions

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Gender of donor influences outcome after orthotopic liver transplantation in adults

1993 • 66 citations

A time-dependent balance between endothelins and nitric oxide regulating portal resistance after endotoxin

1996 • 63 citations

Evidence for a functional link between stress response and vascular control in hepatic portal circulation

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Prematurely evoked synthesis and induction of delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion repression of enzyme formation.

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Preheparinization improves organ function after hemorrhage and resuscitation

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Endothelial Cell Dysfunction Occurs after Hemorrhage in Nonheparinized but Not in Preheparinized Models

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Attenuation of Vascular Endothelial Dysfunction by Testosterone Receptor Blockade After Trauma and Hemorrhagic Shock

2001 • 38 citations

Standardized Trauma Resuscitation

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Endothelin 1 Impairs Oxygen Delivery in Livers From LPS-Primed Animals

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Dehydroepiandrosterone Restores Hepatocellular Function and Prevents Liver Damage in Estrogen-Deficient Females Following Trauma and Hemorrhage

2001 • 21 citations

ROLES OF CYCLOOXYGENASE-2 IN TISSUE INJURY DURING HEMORRHAGIC SHOCK

2000 • 15 citations

Trauma Models for Studying the Influence of Gender and Aging

2001 • 5 citations