Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat

Cloned Glutamate Receptors

1994 • 3,989 citations

New Tables for Multiple Comparisons with a Control

1964 • 3,084 citations

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

1977 • 2,494 citations

The formalin test in mice: dissociation between inflammatory and non-inflammatory pain

1987 • 2,156 citations

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

1993 • 2,006 citations

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists

1988 • 1,202 citations

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a Neuroprotectant for Cerebral Ischemia

1990 • 1,125 citations

Modified formalin test: characteristic biphasic pain response

1989 • 971 citations

The TINS/TiPS Lecture the molecular biology of mammalian glutamate receptor channels

1993 • 882 citations

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

1987 • 836 citations

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

1987 • 666 citations

The formalin test: scoring properties of the first and second phases of the pain response in rats

1995 • 585 citations

Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A

1993 • 581 citations

The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury

1992 • 564 citations

Evidence for spinal N-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

2016 • 516 citations

Evidence for spinalN-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

1990 • 458 citations

Glutamate receptor channels in rat DRG neurons: Activation by kainate and quisqualate and blockade of desensitization by con A

1990 • 420 citations

Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons

1995 • 366 citations

GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses

1993 • 359 citations

The rat paw formalin test: comparison of noxious agents

1990 • 351 citations

Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid neurotransmitters

1994 • 266 citations

The formalin test: a validation of the weighted-scores method of behavioural pain rating

1993 • 231 citations

Activity of 2,3-benzodiazepines at Native Rat and Recombinant Human Glutamate Receptors In Vitro : Stereospecificity and Selectivity Profiles

1996 • 192 citations

A benzodiazepine recognition site associated with the non-NMDA glutamate receptor

1993 • 186 citations

Intracellular Messengers Contributing to Persistent Nociception and Hyperalgesia Induced by _L‐Glutamate and Substance P in the Rat Formalin Pain Model

1994 • 155 citations

(3SR,4aRS,6RS,8aRS)-6-[2-(1H-Tetrazol-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist

1993 • 120 citations

A comparison of excitatory amino acid antagonists acting at primary afferent C fibres and motoneurones of the isolated spinal cord of the rat

1987 • 109 citations

Pharmacological discrimination of GluR5 and GluR6 kainate receptor subtypes by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisdoquinoline-3 carboxylic-acid.

1996 • 98 citations

Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat

1994 • 97 citations

Cyclothiazide reverses AMPA receptor antagonism of the 2,3-benzodiazepine, GYKI 53655

1993 • 67 citations

In vitro and in vivo antagonism of AMPA receptor activation by (3s,4ar,6r,8ar)-6-[2-(1(2)h-tetrazole-5-yl)ethyl]decahydroisoquinoline-3-carboxylic acid

1995 • 65 citations

Structure-activity relationships of 2,3-benzodiazepine compounds with glutamate antagonistic action

1993 • 59 citations

Primary afferent depolarization in the rat spinal cord is mediated by pathways utilising NMDA and non-NMDA receptors

1989 • 55 citations

Structure−Activity Studies of 6-(Tetrazolylalkyl)-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 1. Effects of Stereochemistry, Chain Length, and Chain Substitution

1996 • 47 citations

AMPA receptors have an equal role in spinal nociceptive and non-nociceptive transmission

1994 • 47 citations

A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord

1994 • 33 citations

Structure−Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity

1996 • 32 citations

Structure-activity studies of aryl-spaced decahydroisoquinoline-3-carboxylic acid ampa receptor antagonists

1997 • 25 citations