Treatment of patients with melanoma of the extremity using hyperthermic isolated limb perfusion with melphalan, tumor necrosis factor, and interferon gamma: results of a tumor necrosis factor dose-escalation study.

High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma.

1992 • 730 citations

Studies on the anti-tumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo.

1987 • 292 citations

Hyperthermic perfusion with chemotherapy for cancers of the extremities.

1969 • 172 citations

Isolated limb perfusion for melanoma: Effectiveness and toxicity of cisplatin compared with that of melphalan and other drugs

1992 • 130 citations

Tumor‐necrosis factor can enhance radio‐antibody uptake in human colon carcinoma xenografts by increasing vascular permeability

1993 • 115 citations

Prognostic factors for tumor response and limb recurrence-free interval in patients with advanced melanoma of the limbs treated with regional isolated perfusion with melphalan.

1994 • 102 citations

Action of p -{Di(2-chloroethyl)}-amino-L-phenylalanine on Harding-Passey Mouse Melanoma

1956 • 71 citations

Isolation perfusion for malignant melanoma of the extremity: a review.

1985 • 56 citations

Results of 206 isolated limb perfusions for malignant melanoma.

1989 • 45 citations

Antitumor effect of recombinant tumor necrosis factor-? against murine sarcomas at visceral sites: tumor size influences the response to therapy

1988 • 42 citations

Hyperthermic regional perfusion with melphalan and a combination of melphalan and actinomycin D in the treatment of locally metastasized malignant melanomas of the extremities

1982 • 35 citations

High serum levels of TNF-α after its administration for isolation perfusion of the limb

1992 • 33 citations

Isolated limb perfusion with high-dose tumor necrosis factor for extremity melanoma and sarcoma.

1994 • 21 citations

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