High serum levels of TNF-α after its administration for isolation perfusion of the limb

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma.

1992 • 730 citations

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

1986 • 701 citations

Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits.

1988 • 603 citations

Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock

1990 • 555 citations

High circulating levels of interleukin-6 in patients with septic shock: Evolution during sepsis, prognostic value, and interplay with other cytokines

1991 • 446 citations

Cachectin/tumor necrosis factor exerts endocrine, paracrine, and autocrine control of inflammatory responses.

1988 • 441 citations

The biology of the interferon system 1984

1985 • 413 citations

Induction of the synthesis of tumor necrosis factor receptors by interferon-gamma.

1986 • 328 citations

Divergent Efficacy of Antibody to Tumor Necrosis Factor- in Intravascular and Peritonitis Models of Sepsis

1991 • 275 citations

Cutaneous Melanoma: Clinical Management and Treatment Results Worldwide

1985 • 251 citations

Effect of tumour necrosis factor on cultured human melanoma cells

1975 • 240 citations

A phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients.

1988 • 220 citations

Role of tumor necrosis factor-alpha in lipopolysaccharide-induced pathologic alterations.

1990 • 174 citations

Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon gamma.

1989 • 124 citations

A phase I clinical trial of recombinant human tumor necrosis factor

1988 • 115 citations

Cathepsin-G and leukocyte elastase inactivate human tumor necrosis factor and lymphotoxin

1991 • 90 citations

Effect of intraperitoneal recombinant human tumour necrosis factor alpha on malignant ascites

1991 • 69 citations

Phase I trial of recombinant human gamma-interferon and recombinant human tumor necrosis factor in patients with advanced gastrointestinal cancer.

1989 • 67 citations

Resistance of tumor cells to tumor necrosis factor

1988 • 45 citations

Experimental elimination of tumor necrosis factor in low-dose endotoxin models has variable effects on survival

1991 • 38 citations

A simple and accurate new method for cytostatics dosimetry in isolation perfusion of the limbs based on exchangeable blood volume determination.

1987 • 34 citations

Intralesional tumour necrosis factor combined with interferon gamma in metastatic melanoma.

1989 • 24 citations

Recombinant tumour necrosis factor alpha administered subcutaneously or intramuscularly for treatment of advanced malignant disease: a phase I trial

1991 • 18 citations

Role of tumour necrosis factor in the tumour-necrotizing activity of agents with diverging toxicity

1991 • 12 citations

Effect of tumor necrosis factor on human tumor cell lines sensitive and resistant to cytotoxic drugs, and its interaction with chemotherapeutic agents

1990 • 10 citations

Combined effects of tumor necrosis factor alpha and radiation in the treatment of renal cell carcinoma grown as radia spheroids.

1990 • 6 citations

Increased peripheral blood leukocyte cytotoxic activity in cancer patients during the continuous intravenous administration of recombinant human tumor necrosis factor

1989 • 6 citations

Evaluation of cytokine levels in whole cell cultures of patients with gynaecological tumors as diagnostic parameters.

1991 • 5 citations