Metallothionein Mediates the Level and Activity of Nuclear Factor ΚB in Murine Fibroblasts

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Identification and characterization of a fibroblast marker: FSP1.

1995 • 1,050 citations

Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals

1985 • 1,042 citations

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

1999 • 1,001 citations

Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors

1995 • 815 citations

The Beginning of the End: IκB Kinase (IKK) and NF-κB Activation

1999 • 635 citations

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

1994 • 624 citations

Induction of a New Metallothionein Isoform (MT-IV) Occurs during Differentiation of Stratified Squamous Epithelia

1994 • 556 citations

Metallothioneins: new functional and structural insights

2000 • 401 citations

Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFκB, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line

2002 • 383 citations

Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse.

1993 • 381 citations

DNA binding of purified transcription factor NF-kappa B. Affinity, specificity, Zn2+ dependence, and differential half-site recognition.

1991 • 349 citations

Thionein (apometallothionein) can modulate DNA binding and transcription activation by zinc finger containing factor Spl

1991 • 252 citations

Molecular biology and toxicology of metals

2000 • 218 citations

Cellular Zinc and Redox States Converge in the Metallothionein/Thionein Pair

2003 • 200 citations

Expression and regulation of brain metallothionein

1995 • 162 citations

Cysteine proteinase cathepsin L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts.

1987 • 151 citations

Activation of nuclear factor kappaB: potential role in metallothionein-mediated mitogenic response.

1998 • 142 citations

Metallothioneins and Cell Death by Anticancer Drugs

1995 • 119 citations

Regulatory role of metallothionein in NF‐κB activation

1999 • 87 citations

Basal metallothionein in tumors: Widespread presence of apoprotein

1994 • 82 citations

Immunohistochemical localization of metallothionein in human testicular embryonal carcinoma cells

1989 • 71 citations

Activation of Human Monocytes with Lipopolysaccharide Induces Metallothionein Expression and Is Diminished by Zinc

1994 • 70 citations

Augmented Humoral Immune Function in Metallothionein-Null Mice

2000 • 62 citations

Short-Term Zinc Deficiency Affects Nuclear Factor-κB Nuclear Binding Activity in Rat Testes

2001 • 60 citations

Antisense down-regulation of metallothionein in a human monocytic cell line alters adherence, invasion, and the respiratory burst.

1994 • 54 citations

A sensitive time-resolved fluorescent immunoassay for metallothionein protein

2003 • 40 citations

Metallothionein modulates lipopolysaccharide-stimulated tumour necrosis factor expression in mouse peritoneal macrophages

2002 • 36 citations

Overexpression of Metallothionein-II Sensitizes Rodent Cells to Apoptosis Induced by DNA Cross-linking Agent through Inhibition of NF-κB Activation

2002 • 31 citations

Metallothionein expression and resistance to cisplatin in a human germ cell tumor cell line.

1995 • 30 citations

Zinc treatment, metallothionein expression, and resistance to cisplatin in mouse melanoma cells

1990 • 29 citations

Zinc-Induced Activation of the Human Cytomegalovirus Major Immediate-Early Promoter Is Mediated by Metallothionein and Nuclear Factor-κB

2001 • 26 citations

Overexpression of metallothionein confers resistance to the cytotoxic effect of TNF with cadmium in MCF-7 breast carcinoma cells.

1992 • 25 citations

Zinc-Metallothionein Levels Are Correlated with Enhanced Glucocorticoid Responsiveness in Mouse Cells Exposed to ZnCl2, HgCl2, and Heat Shock

2001 • 23 citations

Enhanced transcription of metallothionein genes in rat kidney: effect of uninephrectomy and compensatory renal growth

1995 • 21 citations

Nuclease sensitivity of α-fetoprotein, metallothionein-1, and immunoglobulin gene sequences in mouse during development

1987 • 20 citations

Radioimmunoassay of metallothionein in rabbit, rat, mouse, Chinese hamster, and human cells

1991 • 17 citations