Inactivation of BHD in sporadic renal tumors.

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

de la Chapelle, A.

1997 • 3,184 citations

Cancer Statistics, 2002

2002 • 2,954 citations

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

1993 • 2,906 citations

Methylation-Induced Repression— Belts, Braces, and Chromatin

1999 • 1,823 citations

BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences

1999 • 1,813 citations

Mutations of the VHL tumour suppressor gene in renal carcinoma

1994 • 1,719 citations

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

2000 • 1,628 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

2002 • 1,541 citations

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

1997 • 1,508 citations

CpG islands as gene markers in the human genome

1992 • 908 citations

Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome

2002 • 882 citations

Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

2001 • 747 citations

Effects of DNA methylation on DNA-binding proteins and gene expression

1993 • 732 citations

Hereditary Multiple Fibrofolliculomas With Trichodiscomas and Acrochordons

1977 • 711 citations

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.

1989 • 554 citations

Novel mutations of the MET proto-oncogene in papillary renal carcinomas

1999 • 502 citations

Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas.

1994 • 469 citations

Histone deacetylases: silencers for hire

2000 • 429 citations

Renal cell carcinoma.

2006 • 382 citations

Somatic mutations of the von Hippel — Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma

1994 • 371 citations

Birt-Hogg-Dubé Syndrome

1999 • 366 citations

Birt-Hogg-Dubé Syndrome, a Genodermatosis Associated with Spontaneous Pneumothorax and Kidney Neoplasia, Maps to Chromosome 17p11.2

2001 • 360 citations

Large-scale human promoter mapping using CpG islands

2000 • 302 citations

Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization.

1994 • 279 citations

Inactivation of the von Hippel–Lindau ( VHL ) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL ‐independent pathway in clear cell renal tumourigenesis

1998 • 255 citations

VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation.

2000 • 227 citations

Semiautomated assessment of loss of heterozygosity and replication error in tumors.

1996 • 222 citations

Clinical and genetic studies of Birt-Hogg-Dube syndrome

2002 • 212 citations

Birt-Hogg-Dubé syndrome: mapping of a novel hereditary neoplasia gene to chromosome 17p12-q11.2

2001 • 201 citations

Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families.

2002 • 159 citations

Cytogenetic analysis of six renal oncocytomas and a chromophobe cell renal carcinoma

1992 • 125 citations

Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence

2002 • 108 citations

Fibrofolliculomas, tricodiscomas and acrochordons (Birt-Hogg-Dube) associated with intestinal polyposis

1989 • 102 citations

Mammalian Methyltransferases and Methyl-CpG-Binding Domains: Proteins Involved in DNA Methylation

2000 • 101 citations

Birt‐Hogg‐Dubé‐syndrome and Hornstein‐Knickenberg‐syndrome are the same. Different sectioning technique as the cause of different histology

1999 • 94 citations

Allelic losses at chromosomes 1p, 2p, 6p, 10p, 13q, 17p, and 21q significantly correlate with the chromophobe subtype of renal cell carcinoma.

1996 • 76 citations

Fluorescence In Situ Hybridization Analysis of Renal Oncocytoma Reveals Frequent Loss of Chromosomes Y and 1

1996 • 62 citations

Involvement of the chromosomal region 11q13 in renal oncocytoma: Case report and literature review

1997 • 46 citations

Loss of heterozygosity studies and deletion mapping identify two putative chromosome 14q tumor suppressor loci in renal oncocytomas.

1997 • 19 citations