Increased Rate of Phenocopies in All Age Groups in BRCA1/BRCA2 Mutation Kindred, but Increased Prospective Breast Cancer Risk Is Confined to BRCA2 Mutation Carriers

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

1998 • 2,920 citations

Genome-wide association study identifies novel breast cancer susceptibility loci

2007 • 2,342 citations

The Risk of Cancer Associated with Specific Mutations ofBRCA1andBRCA2among Ashkenazi Jews

1997 • 2,255 citations

Risks of cancer in BRCA1-mutation carriers

1994 • 1,865 citations

Cancer Risks in BRCA2 Mutation Carriers

1999 • 1,477 citations

- Statistical Models for Epidemiology

2013 • 1,393 citations

A breast cancer prediction model incorporating familial and personal risk factors

2004 • 1,203 citations

Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS)

2005 • 1,020 citations

Genome-wide association study identifies five new breast cancer susceptibility loci

2010 • 694 citations

Statistical Models in Epidemiology

1994 • 430 citations

Prevalence and Penetrance of BRCA1 and BRCA2 Gene Mutations in Unselected Ashkenazi Jewish Women With Breast Cancer

1999 • 390 citations

Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

2008 • 281 citations

Population-based estimate of the average age-specific cumulative risk of breast cancer for a defined set of protein-truncating mutations in BRCA1 and BRCA2. Australian Breast Cancer Family Study.

1999 • 262 citations

A new scoring system for the chances of identifying a BRCA1/2 mutation outperforms existing models including BRCAPRO

2004 • 254 citations

Penetrance estimates for BRCA1 and BRCA2based on genetic testing in a Clinical Cancer Genetics service setting: Risks of breast/ovarian cancer quoted should reflect the cancer burden in the family

2008 • 221 citations

On the Use of Familial Aggregation in Population-Based Case Probands for Calculating Penetrance

2002 • 203 citations

Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

2010 • 179 citations

Assessing Individual Breast Cancer Risk within the U.K. National Health Service Breast Screening Program: A New Paradigm for Cancer Prevention

2012 • 115 citations

Phenocopies in BRCA1 and BRCA2 families: evidence for modifier genes and implications for screening

2006 • 113 citations

The T/G 13915 variant upstream of the lactase gene (LCT) is the founder allele of lactase persistence in an urban Saudi population

2007 • 102 citations

Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2mutation carriers

2012 • 93 citations

Risk reducing mastectomy: outcomes in 10 European centres

2008 • 86 citations

Breast cancer risks in individuals testing negative for a known family mutation in BRCA1 or BRCA2

2009 • 49 citations

Breast Cancer Risk for Noncarriers of Family-Specific BRCA1 and BRCA2 Mutations: Findings From the Breast Cancer Family Registry

2011 • 42 citations

Breast cancer susceptibility variants alter risks in familial disease

2009 • 40 citations

A prospective study of breast cancer risk in relatives of BRCA1/BRCA2 mutation carriers.

2007 • 27 citations

No evidence of excess breast cancer risk among mutation-negative women from BRCA mutation-positive families

2010 • 25 citations

Proven non-carriers in BRCA families have an earlier age of onset of breast cancer

2013 • 18 citations

Prospective study of breast cancer risk for mutation negative women from BRCA1 or BRCA2 mutation positive families

2011 • 16 citations