Repression of the immunoglobulin heavy chain 3′ enhancer by helix‐loop‐helix protein Id3 via a functionally important E47/E12 binding site: implications for developmental control of enhancer function

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

The protein Id: A negative regulator of helix-loop-helix DNA binding proteins

1990 • 2,273 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1994 • 766 citations

The helix-loop-helix gene E2A is required for B cell formation

1994 • 679 citations

Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins.

1991 • 601 citations

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

1990 • 584 citations

Two Distinct Transcription Factors that Bind the Immunoglobulin Enhancer μE5/κE2 Motif

1990 • 478 citations

MyoD expression in the forming somites is an early response to mesoderm induction in Xenopus embryos.

1989 • 374 citations

The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein.

1994 • 371 citations

An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene.

1991 • 352 citations

HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.

1992 • 312 citations

Immunoglobulin Gene Transcription

1991 • 294 citations

The expression pattern ofId4, a novel dominant negative helix-loop-helix protein, is distinct fromId1,1d2andId3

1994 • 274 citations

A class switch control region at the 3′ end of the immunoglobulin heavy chain locus

1994 • 267 citations

Constitutive expression of the Id1 gene impairs mouse B cell development

1994 • 266 citations

Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells.

1994 • 258 citations

Mammalian ets-1 and ets-2 genes encode highly conserved proteins.

1988 • 248 citations

Id proteins control growth induction in mammalian cells.

1994 • 229 citations

Consequences of heteromeric interactions among helix-loop-helix proteins.

1993 • 226 citations

A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus

1990 • 220 citations

Dependence of Enhancer-Mediated Transcription of the Immunoglobulin μ Gene on Nuclear Matrix Attachment Regions

1994 • 216 citations

The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region.

1989 • 213 citations

Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs.

1990 • 199 citations

Regulation of G1 progression by E2A and Id helix-loop-helix proteins.

1994 • 199 citations

B-Cell- and Myocyte-Specific E2-Box-Binding Factors Contain E12/E47-Like Subunits

1991 • 164 citations

E2A and E2-2 are Subunits of B-Cell-Specific E2-Box DNA-Binding Proteins

1993 • 153 citations

Repression of immunoglobulin enhancers by the helix-loop-helix protein Id: implications for B-lymphoid-cell development.

1991 • 151 citations

NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation.

1993 • 151 citations

The mouse IgH 3′‐enhancer

1991 • 139 citations

A human Id-like helix-loop-helix protein expressed during early development.

1992 • 138 citations

Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors.

1991 • 123 citations

An enhancer element in the short unique region of human cytomegalovirus regulates the production of a group of abundant immediate early transcripts

1988 • 110 citations

Mutually exclusive expression of a helix-loop-helix gene and N-myc in human neuroblastomas and in normal development.

1992 • 109 citations

The murine Ig 3' alpha enhancer is a target site with repressor function for the B cell lineage-specific transcription factor BSAP (NF-HB, S alpha-BP).

1994 • 101 citations

An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types.

1993 • 98 citations

E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins.

1993 • 92 citations

The Immunoglobulin Heavy Chain Locus Contains Another B-Cell-Specific 3' Enhancer Close to the α Constant Region

1993 • 92 citations

SV40 recombinants carrying a functional RNA splice junction and polyadenylation site from the chromosomal mouse βmaj globin gene

1979 • 91 citations

A cDNA from a mouse pancreatic β cell encoding a putative transcription factor of the insulin gene

1990 • 91 citations

The importance of the 3′-enhancer region in immunoglobulinxgene expression

1990 • 83 citations

DNA regions flanking the mouse Ig 3' alpha enhancer are differentially methylated and DNAase I hypersensitive during B cell differentiation.

1993 • 71 citations

E2A expression, nuclear localization, and in vivo formation of DNA- and non-DNA-binding species during B-cell development.

1993 • 66 citations

B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits.

1991 • 64 citations

Identification of Ets-like lymphoid specific elements within the immunoglobulin heavy chain 3′ enhancer

1992 • 61 citations

Activation of Helix-Loop-Helix Proteins Id1, Id2 and Id3 during Neural Differentiation

1994 • 58 citations

The half-life of immunoglobulin mRNA increases during B-cell differentiation: a possible role for targeting to membrane-bound polysomes.

1988 • 57 citations

Lipopolysaccharide‐dependent transactivation of the temporally regulated immunoglobulin heavy chain 3′ enhancer

1994 • 55 citations

The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region.

1993 • 50 citations

A second promoter and enhancer element within the immunoglobulin heavy chain locus

1994 • 50 citations

Cell-specific expression of helix-loop-helix transcription factors encoded by the E2A gene

1993 • 22 citations