UCHL1 is a Parkinson's disease susceptibility gene

Bias in meta-analysis detected by a simple, graphical test

1997 • 47,526 citations

Meta-analysis in clinical trials

1986 • 36,193 citations

Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>

2000 • 18,725 citations

Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.

1992 • 9,892 citations

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

1988 • 3,339 citations

Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits

2002 • 2,077 citations

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

2003 • 1,925 citations

Replication validity of genetic association studies

2001 • 1,845 citations

Association study designs for complex diseases

2001 • 1,415 citations

Generalized linear mixed models a pseudo-likelihood approach

1993 • 1,274 citations

Publication bias in meta-analysis its causes and consequences

2000 • 1,110 citations

The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility

2002 • 768 citations

Genetic associations in large versus small studies: an empirical assessment

2003 • 595 citations

Meta-analysis of Observational Studies in Epidemiology

2000 • 448 citations

Model-Free Analysis and Permutation Tests for Allelic Associations

1999 • 423 citations

Reporting, Appraising, and Integrating Data on Genotype Prevalence and Gene-Disease Associations

2002 • 377 citations

Gm3;5,13,14 and type 2 diabetes mellitus: an association in American Indians with genetic admixture.

1988 • 375 citations

alpha-synuclein gene haplotypes are associated with Parkinson's disease

2001 • 347 citations

Meta-analyses of molecular association studies: Methodologic lessons for genetic epidemiology

2003 • 309 citations

Impairment of the ubiquitin‐proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

2002 • 297 citations

Parameters for reliable results in genetic association studies in common disease

2002 • 237 citations

The demonstration of new human brain-specific proteins by high-resolution two-dimensional polyacrylamide gel electrophoresis

1981 • 215 citations

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson’s disease

1999 • 214 citations

Atypical antipsychotics in the treatment of drug-induced psychosis in Parkinson's disease

2000 • 213 citations

Proteolytic stress: A unifying concept for the etiopathogenesis of Parkinson's disease

2003 • 204 citations

Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

2001 • 198 citations

Expression of ?-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: Genes associated with familial Parkinson's disease

2000 • 195 citations

Selection and Evaluation of Tagging SNPs in the Neuronal-Sodium-Channel Gene SCN1A: Implications for Linkage-Disequilibrium Gene Mapping

2003 • 191 citations

Evolution of treatment effects over time: Empirical insight from recursive cumulative metaanalyses

2001 • 185 citations

Genome scans and candidate gene approaches in the study of common diseases and variable drug responses

2003 • 165 citations

Mutation analysis and association studies of the UCHL1 gene in German Parkinsonʼs disease patients

2000 • 142 citations

Low frequency of pathogenic mutations in the ubiquitin carboxyterminal hydrolase gene in familial Parkinsonʼs disease

1999 • 119 citations

Commentary: Meta-analysis of Individual Participants' Data in Genetic Epidemiology

2002 • 118 citations

A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population

2001 • 89 citations

S18Y polymorphism in the UCH‐L1 gene and Parkinson's disease: Evidence for an age‐dependent relationship

2002 • 73 citations

Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease

2000 • 67 citations

ACT and UCH‐L1 polymorphisms in Parkinson's disease and age of onset

2002 • 51 citations

The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease

2000 • 51 citations

No genetic association of the Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism with familial Parkinson's disease

2001 • 44 citations

The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism

2004 • 43 citations

Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease

2005 • 36 citations

Complex interactions in Parkinson's disease: A two‐phased approach

2003 • 34 citations

Linkage exclusion in French families with probable Parkinson's disease

2000 • 33 citations

Lack of association between ubiquitin carboxy-terminal hydrolase L1 gene polymorphism and PD

2001 • 30 citations

Analysis, reanalysis, and meta-analysis in neurology

2001 • 2 citations