The GCN2 eIF2α Kinase Is Required for Adaptation to Amino Acid Deprivation in Mice

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

2001 • 1,329 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1992 • 768 citations

Attenuation in the control of expression of bacterial operons

1981 • 757 citations

Multiple upstream AUG codons mediate translational control of GCN4

1986 • 654 citations

The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

2002 • 584 citations

Uncharged tRNA Activates GCN2 by Displacing the Protein Kinase Moiety from a Bipartite tRNA-Binding Domain

2000 • 474 citations

The Histidyl-tRNA Synthetase-Related Sequence in the eIF-2α Protein Kinase GCN2 Interacts with tRNA and Is Required for Activation in Response to Starvation for Different Amino Acids

1995 • 455 citations

Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation

2001 • 328 citations

Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability.

1989 • 278 citations

A Mammalian Homologue of GCN2 Protein Kinase Important for Translational Control by Phosphorylation of Eukaryotic Initiation Factor-2α

2000 • 276 citations

Positive and negative regulatory mechanisms that mediate long-term memory storage

1998 • 270 citations

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2α kinase

1999 • 254 citations

Regulation of Amino Acid Metabolism

1969 • 193 citations

Implication of eIF2B Rather Than eIF4E in the Regulation of Global Protein Synthesis by Amino Acids in L6 Myoblasts

1998 • 166 citations

Adaptation of Rats to Diets Containing Different Levels of Protein: Effects on Food Intake, Plasma and Brain Amino Acid Concentrations and Brain Neurotransmitter Metabolism

1985 • 158 citations

Presence of ATG triplets in 5′ untranslated regions of eukaryotic cDNAs correlates with a ‘weak’ context of the start codon

2001 • 149 citations

Pancreatic eukaryotic initiation factor-2α kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

2000 • 147 citations

Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation

2000 • 146 citations

elF-2 kinases: regulators of general and gene-specific translation initiation

1994 • 140 citations

Sequences that surround the stop codons of upstream open reading frames in GCN4 mRNA determine their distinct functions in translational control.

1989 • 121 citations

Mechanism of inhibition of peptide chain initiation by amino acid deprivation in perfused rat liver. Regulation involving inhibition of eukaryotic initiation factor 2 alpha phosphatase activity

1991 • 114 citations

Histidyl-tRNA Synthetase-related Sequences in GCN2 Protein Kinase Regulate in Vitro Phosphorylation of eIF-2

1996 • 112 citations

Pancreatic eukaryotic initiation factor-2α kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

2000 • 109 citations

Amino acid-induced stimulation of translation initiation in rat skeletal muscle

1999 • 106 citations

The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

2001 • 105 citations

Regulation of Translation Initiation by Amino Acids in Eukaryotic Cells

2001 • 104 citations

Amino acid‐regulated gene expression in eukaryotic cells

1994 • 98 citations

The role of amino acids in the regulation of protein synthesis in perfused rat liver. II. Effects of amino acid deficiency on peptide chain initiation, polysomal aggregation, and distribution of albumin mRNA.

1982 • 92 citations

Effects of Hypophysectomy on Amino Acid Metabolism and Gluconeogenesis in the Perfused Rat Liver

1973 • 92 citations

Hepatic metabolism of genetically diabetic (db/db) mice. I. Carbohydrate metabolism

1975 • 81 citations

Cloning and Characterization of a cDNA Encoding a Protein Synthesis Initiation Factor-2α (eIF-2α) Kinase fromDrosophila melanogaster

1997 • 76 citations

GI Domain-mediated Association of the Eukaryotic Initiation Factor 2α Kinase GCN2 with Its Activator GCN1 Is Required for General Amino Acid Control in Budding Yeast

2000 • 74 citations

Transcriptional and Translational Regulation of Gene Expression in the General Control of Amino-Acid Biosynthesis in Saccharomyces cerevisiae

1990 • 65 citations

Amino Acid Regulation of Gene Expression

2001 • 62 citations

Effect of Different Protein Diets on the Distribution of Amino Acids in Plasma, Liver and Brain in the Rat

1992 • 59 citations

Purification and characterization of eukaryotic initiation factor 2 and a guanine nucleotide exchange factor from rat liver.

1987 • 56 citations

cpc-3, the Neurospora crassa Homologue of Yeast GCN2, Encodes a Polypeptide with Juxtaposed eIF2α Kinase and Histidyl-tRNA Synthetase-related Domains Required for General Amino Acid Control

1998 • 55 citations

Initiation of protein synthesis in a cell-free system prepared from rat hepatocytes

1989 • 55 citations

Purification and characterization of eukaryotic translational initiation factor eIF-2B from liver

1994 • 54 citations

Multicopy tRNA Genes Functionally Suppress Mutations in Yeast eIF-2α Kinase GCN2: Evidence for Separate Pathways Coupling GCN4 Expression to Uncharged tRNA

1994 • 54 citations

Isolation of the Gene Encoding the Drosophila melanogaster Homolog of the Saccharomyces cerevisiae GCN2 eIF-2α Kinase

1998 • 53 citations

Prediction of Brain and Serum Free Amino Acid Profiles in Rats Fed Graded Levels of Protein

1986 • 38 citations

Role of Translation Initiation Factor elF-2B in the Regulation of Protein Synthesis in Mammalian Cells

1996 • 36 citations