Using Cyclooxygenase-2 Inhibitors as Molecular Platforms to Develop a New Class of Apoptosis-Inducing Agents

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

1997 • 1,901 citations

Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.

2000 • 1,310 citations

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

1998 • 1,130 citations

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

1999 • 830 citations

The Cyclooxygenase-2 Inhibitor Celecoxib Induces Apoptosis by Blocking Akt Activation in Human Prostate Cancer Cells Independently of Bcl-2

2000 • 670 citations

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2

2000 • 627 citations

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

2000 • 529 citations

Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor.

2000 • 494 citations

Cyclooxygenase-2 and carcinogenesis

2000 • 489 citations

A graphics program for the analysis and display of molecular dynamics trajectories

1992 • 462 citations

Cyclooxygenase-2 inhibition by celecoxib reduces proliferation and induces apoptosis in angiogenic endothelial cells in vivo.

2002 • 444 citations

Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis.

1995 • 433 citations

Visualization of solvation structures in liquid mixtures

1997 • 429 citations

Cyclooxygenase-2: a novel target for cancer chemotherapy?

2001 • 423 citations

Clinical Pharmacokinetics and Pharmacodynamics of Celecoxib

2000 • 404 citations

Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.

2000 • 296 citations

Cyclooxygenase-2, Player or Spectator in Cyclooxygenase-2 Inhibitor-Induced Apoptosis in Prostate Cancer Cells

2002 • 248 citations

Non-steroidal anti-inflammatory drugs and bladder cancer prevention

2000 • 214 citations

Sulfone metabolite of sulindac inhibits mammary carcinogenesis.

1997 • 211 citations

Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines

1999 • 211 citations

Inverse association of prostate cancer and non-steroidal anti-inflammatory drugs (NSAIDs): results of a case-control study.

2000 • 166 citations

COMPLETE ANDROGEN BLOCKADE FOR PROSTATE CANCER: WHAT WENT WRONG?

2000 • 115 citations

COX-2 and colon cancer: Potential targets for chemoprevention

2000 • 115 citations

Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

1996 • 107 citations

Anti-Inflammatories Inhibit Cancer Growth--But How?

2001 • 99 citations

Synthesis and Biological Evaluation of 3,4-Diaryloxazolones: A New Class of Orally Active Cyclooxygenase-2 Inhibitors

1999 • 94 citations

Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells

2000 • 91 citations

Cyclooxygenase-2 Expression Inhibits Trophic Withdrawal Apoptosis in Nerve Growth Factor-differentiated PC12 Cells

2000 • 85 citations

Apoptosis signaling pathways mediated by cyclooxygenase-2 inhibitors in prostate cancer cells

2001 • 68 citations

Sulindac and its derivatives: a novel class of anticancer agents.

2001 • 55 citations

Is COX-2 inhibition a panacea for cancer prevention?

2001 • 46 citations

Nonsteroidal anti-inflammatory drugs, COX-2 and colorectal cancer

2000 • 42 citations

Extent, mode, and dose dependence of anticancer effects

2001 • 41 citations

COX-2 inhibition in clinical cancer prevention.

2001 • 37 citations

NSAIDs inhibit the activation of egr-1 gene in microvascular endothelial cells. A key to inhibition of angiogenesis?

2001 • 35 citations

The Role of Eicosanoids, Cyclooxygenases, and Nonsteroidal Anti-inflammatory Drugs in Colorectal Tumorigenesis and Chemoprevention

2002 • 16 citations

PROSTAGLANDIN INHIBITORS AND THE CHEMOPREVENTION OF NONCOLONIC MALIGNANCY

2001 • 14 citations

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