Role of Feeding-Related Pathways in Alcohol Dependence: A Focus on Sweet Preference, NPY, and Ghrelin

A psychomotor stimulant theory of addiction.

1987 • 2,704 citations

Seasonal Affective Disorder

1984 • 2,272 citations

How can drug addiction help us understand obesity?

2005 • 1,065 citations

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

2006 • 922 citations

Alcoholism: Allostasis and Beyond

2003 • 738 citations

Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food.

1991 • 678 citations

Extent and Direction of Ghrelin Transport Across the Blood-Brain Barrier Is Determined by Its Unique Primary Structure

2002 • 676 citations

Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?

2005 • 637 citations

Reward deficiency syndrome: genetic aspects of behavioral disorders

2000 • 620 citations

Voluntary consumption of ethanol in 15 inbred mouse strains

1993 • 564 citations

Neurobiology of opiate abuse

1992 • 546 citations

Opioid modulation of taste hedonics within the ventral striatum

2002 • 514 citations

Ethanol consumption and resistance are inversely related to neuropeptide Y levels

1998 • 477 citations

PRECLINICAL STUDY: Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens

2006 • 400 citations

Requirement of central ghrelin signaling for alcohol reward

2009 • 395 citations

Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models

1989 • 378 citations

Variations in human taste bud density and taste intensity perception

1990 • 359 citations

PRECLINICAL STUDY: Ghrelin stimulates locomotor activity and accumbal dopamine‐overflow via central cholinergic systems in mice: implications for its involvement in brain reward

2006 • 342 citations

Corticotropin-releasing factor and neuropeptide y: role in emotional integration

1994 • 320 citations

Feeding and drinking elicited by central injection of neuropeptide Y: Evidence for a hypothalamic site(s) of action

1985 • 281 citations

Of human bondage

2002 • 258 citations

Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress

2006 • 250 citations

Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status

1990 • 243 citations

3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism

2007 • 242 citations

Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test

1999 • 239 citations

Neurochemical and behavioral studies on ethanol and nicotine interactions

2003 • 219 citations

Deficits in amygdaloid cAMP-responsive element–binding protein signaling play a role in genetic predisposition to anxiety and alcoholism

2005 • 193 citations

Taste preferences in rat lines selected for low and high alcohol consumption

1992 • 189 citations

PRECLINICAL STUDY: Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine

2008 • 178 citations

Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y gene

2003 • 170 citations

Relationship Between Ghrelin Levels, Alcohol Craving, and Nutritional Status in Current Alcoholic Patients

2006 • 168 citations

Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism

2004 • 152 citations

Ghrelin Levels Are Increased in Alcoholism

2005 • 149 citations

Innate Differences of Neuropeptide Y (NPY) in Hypothalamic Nuclei and Central Nucleus of the Amygdala Between Selectively Bred Rats with High and Low Alcohol Preference

1999 • 145 citations

Effects of body weight and food intake on pleasantness ratings for a sweet stimulus

1976 • 142 citations

Effect of Neuropeptide Y (NPY) on Oral Ethanol Intake in Wistar, Alcohol‐Preferring (P), and ‐Nonpreferring (NP) Rats

2001 • 138 citations

Mood and carbohydrate cravings

2001 • 131 citations

INCREASED FASTING PLASMA GHRELIN LEVELS DURING ALCOHOL ABSTINENCE

2004 • 128 citations

Anxiolytic-like effect of neuropeptide Y (NPY), but not other peptides in an operant conflict test

1992 • 128 citations

Depressive symptoms and the self-reported use of alcohol, caffeine, and carbohydrates in normal volunteers and four groups of psychiatric outpatients

1993 • 126 citations

Effects of Cigarette Smoking and Family History of Alcoholism on Sweet Taste Perception and Food Cravings in Women

2007 • 125 citations

Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens

2008 • 125 citations

Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase

1993 • 113 citations

Family History of Alcoholism and Response to Sweets

2003 • 104 citations

Same genetic components underlie different measures of sweet taste preference

2007 • 102 citations

Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking

2008 • 98 citations

Inhibitory effect of alcohol on ghrelin secretion in normal man

2005 • 95 citations

Neuropeptide-Y in the paraventricular nucleus increases ethanol self-administration

2001 • 91 citations

Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats

2007 • 91 citations

CLINICAL STUDY: Alcohol administration acutely inhibits ghrelin secretion in an experiment involving psychosocial stress

2006 • 90 citations

Alcohol dependence is associated with reduced plasma and fundic ghrelin levels

2008 • 88 citations

Appetite and food preference in depression: Effects of imipramine treatment

1987 • 86 citations

Association of Pro‐Ghrelin and GHS‐R1A Gene Polymorphisms and Haplotypes With Heavy Alcohol Use and Body Mass

2008 • 85 citations

Alcohol Activates a Sucrose-Responsive Gustatory Neural Pathway

2004 • 82 citations

Morphine and acceptability of putative reinforcers

1983 • 79 citations

Comparison of nutrient intake among depressed and nondepressed individuals

1996 • 77 citations

Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors are involved in mediating the ghrelin-induced locomotor stimulation and dopamine overflow in nucleus accumbens

2008 • 76 citations

Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking

2009 • 75 citations

Sweet preferences and analgesia during childhood: effects of family history of alcoholism and depression

2010 • 73 citations

The role of neuropeptide Y in the amygdala on corticotropin-releasing factor receptor-mediated behavioral stress responses in the rat

2006 • 72 citations

Neuropeptide Y Signaling in the Central Nucleus of Amygdala Regulates Alcohol‐Drinking and Anxiety‐Like Behaviors of Alcohol‐Preferring Rats

2009 • 70 citations

Overexpression of Neuropeptide Y in the Central Nucleus of the Amygdala Decreases Ethanol Self‐administration in “Anxious” Rats

2006 • 70 citations

Role of Appetite‐Regulating Peptides in Alcohol Craving: An Analysis in Respect to Subtypes and Different Consumption Patterns in Alcoholism

2007 • 69 citations

Selective actions of central μ and κ opioid antagonists upon sucrose intake in sham-fed rats

1995 • 64 citations

Alcohol ingestion does not affect serum levels of peptide YY but decreases both total and octanoylated ghrelin levels in healthy subjects

2006 • 64 citations

Blood Glucose Level, Alcohol Heavy Drinking, and Alcohol Craving During Treatment for Alcohol Dependence: Results From the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) Study

2009 • 63 citations

Gender Differences for Ghrelin Levels in Alcohol‐Dependent Patients and Differences Between Alcoholics and Healthy Controls

2007 • 62 citations

Novelty Seeking as a Moderator of Familial Risk for Alcohol Dependence

2006 • 62 citations

Three sweet receptor genes are clustered in human Chromosome 1

2003 • 59 citations

Carbohydrate craving, mood changes, and obesity.

1988 • 55 citations

Dual diagnosis and psychiatric treatment : substance abuse and comorbid disorders

2004 • 48 citations

Role of the ghrelin system in alcoholism: Acting on the growth hormone secretagogue receptor to treat alcohol-related diseases

2010 • 47 citations

Neuropeptide Y (NPY) in alcohol intake and dependence

2007 • 46 citations

Neuropeptide Y: Role in Emotion and Alcohol Dependence

2006 • 46 citations

Insulin But Not Insulin Growth Factor‐1 Correlates With Craving in Currently Drinking Alcohol‐Dependent Patients

2008 • 45 citations

Sweet Liking Phenotype, Alcohol Craving and Response to Naltrexone Treatment in Alcohol Dependence

2009 • 45 citations

Effects of neuropeptide Y on ingestion of flavored solutions in nondeprived rats

1993 • 44 citations

Relationship Between the Hypothalamic–Pituitary–Thyroid Axis and Alcohol Craving in Alcohol‐Dependent Patients: A Longitudinal Study

2008 • 42 citations

PERCEIVED INTENSITY AND PLEASANTNESS OF SUCROSE TASTE IN MALE ALCOHOLICS

2006 • 37 citations

Same genetic components underlie different measures of sweet taste preference

2007 • 35 citations

Neuropeptide Y in the Paraventricular Nucleus of the Hypothalamus Increases Ethanol Intake in High‐ and Low‐Alcohol‐Drinking Rats

2004 • 34 citations

Understanding and Treating Alcohol Craving and Dependence: Recent Pharmacological and Neuroendocrinological Findings

2009 • 32 citations

Hunger and satiety in genetically obese mice (C57BL/6J-ob/ob)

1978 • 22 citations

Effects of a Diagnosis or Family History of Alcoholism on the Taste Intensity and Hedonic Value of Sucrose

2009 • 18 citations