Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

2003 • 2,569 citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

2001 • 1,962 citations

Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

2000 • 1,583 citations

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

1998 • 1,314 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

2000 • 807 citations

Radiosensitivity in ataxia-telangiectasia: a new explanation.

1980 • 784 citations

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

2003 • 767 citations

S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

2003 • 645 citations

ATM and ATR: networking cellular responses to DNA damage

2001 • 595 citations

53BP1, a Mediator of the DNA Damage Checkpoint

2002 • 559 citations

Involvement of Brca1 in S-Phase and G₂-Phase Checkpoints after Ionizing Irradiation

2001 • 537 citations

Mrc1 transduces signals of DNA replication stress to activate Rad53

2001 • 518 citations

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

2002 • 473 citations

Two Molecularly Distinct G₂/M Checkpoints Are Induced by Ionizing Irradiation

2002 • 467 citations

A unified view of the DNA-damage checkpoint

2002 • 458 citations

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G ₂ checkpoints

2002 • 446 citations

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

2000 • 412 citations

Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts

2000 • 394 citations

Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53

2003 • 375 citations

Checking on the fork: the DNA-replication stress-response pathway

2002 • 340 citations

SCF^β-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

2003 • 326 citations

Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1

2001 • 234 citations

Human Claspin Is Required for Replication Checkpoint Control

2003 • 232 citations

Claspin, a Chk1-Regulatory Protein, Monitors DNA Replication on Chromatin Independently of RPA, ATR, and Rad17

2003 • 195 citations

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1

2003 • 154 citations

DNA damage: Chk1 and Cdc25, more than meets the eye

2001 • 61 citations