Gap junctions between regulatory T cells and dendritic cells prevent sensitization of CD8+ T cells

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

How regulatory T cells work

2008 • 3,048 citations

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

2007 • 2,215 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Induction of tolerance by IL-10-treated dendritic cells.

1997 • 1,263 citations

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression

2007 • 1,181 citations

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

2005 • 783 citations

Migratory Dendritic Cells Transfer Antigen to a Lymph Node-Resident Dendritic Cell Population for Efficient CTL Priming

2006 • 716 citations

Foxp3⁺natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation

2008 • 663 citations

Cyclic adenosine monophosphate is a key component of regulatory T cell–mediated suppression

2007 • 618 citations

Identification of a novel population of Langerin+ dendritic cells

2007 • 505 citations

Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells

2004 • 472 citations

Connexin 43 hemichannels mediate Ca2+‐regulated transmembrane NAD+ fluxes in intact cells

2000 • 450 citations

Connexin channel permeability to cytoplasmic molecules

2007 • 438 citations

Cross-presentation by intercellular peptide transfer through gap junctions

2005 • 430 citations

On the Dynamics of TCR:CD3 Complex Cell Surface Expression and Downmodulation

2000 • 364 citations

IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells

2004 • 354 citations

ATP Release From Activated Neutrophils Occurs via Connexin 43 and Modulates Adenosine-Dependent Endothelial Cell Function

2006 • 344 citations

CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells

2007 • 311 citations

Cutting Edge: Induction of B7-H4 on APCs through IL-10: Novel Suppressive Mode for Regulatory T Cells

2006 • 277 citations

Connexin37 protects against atherosclerosis by regulating monocyte adhesion

2006 • 267 citations

Connexin and pannexin mediated cell–cell communication

2007 • 225 citations

Lymph Node Occupancy Is Required for the Peripheral Development of Alloantigen-Specific Foxp3+ Regulatory T Cells

2005 • 182 citations

Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation

2003 • 166 citations

CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity

2009 • 150 citations

Mimetic Peptides as Blockers of Connexin Channel-Facilitated Intercellular Communication

2007 • 146 citations

Induction of immunosuppressive functions of dendritic cells in vivo by CD4⁺CD25⁺ regulatory T cells: Role of B7‐H3 expression and antigen presentation

2007 • 129 citations

Modulation of Dendritic Cell Function by Naive and Regulatory CD4+ T Cells

2006 • 128 citations

NAD+ and ATP Released from Injured Cells Induce P2X7-Dependent Shedding of CD62L and Externalization of Phosphatidylserine by Murine T Cells

2009 • 126 citations

Cutting Edge: CD4+CD25+ Regulatory T Cells Impaired for Intestinal Homing Can Prevent Colitis

2005 • 124 citations

CD4⁺CD25⁺ regulatory T cells suppress contact hypersensitivity reactions by blocking influx of effector T cells into inflamed tissue

2006 • 118 citations

Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulations

2000 • 114 citations

Cyclic AMP plays a critical role in C3a-receptor–mediated regulation of dendritic cells in antigen uptake and T-cell stimulation

2008 • 112 citations

Gap Junction Channels Exhibit Connexin-specific Permeability to Cyclic Nucleotides

2008 • 111 citations

Function of the voltage gate of gap junction channels: Selective exclusion of molecules

2002 • 103 citations

Functional Gap Junctions Facilitate Melanoma Antigen Transfer and Cross-Presentation between Human Dendritic Cells

2007 • 94 citations

Gap Junction-Mediated Intercellular Communication between Dendritic Cells (DCs) Is Required for Effective Activation of DCs

2006 • 82 citations

Immunoglobulin and cytokine expression in mixed lymphocyte cultures is reduced by disruption of gap junction intercellular communication

2001 • 80 citations

Enhanced Neurite Outgrowth in PC12 Cells Mediated by Connexin Hemichannels and ATP

2006 • 73 citations

Direct cell/cell communication in the lymphoid germinal center: connexin43 gap junctions functionally couple follicular dendritic cells to each other and to B lymphocytes

1997 • 70 citations

CD80 Cytoplasmic Domain Controls Localization of CD28, CTLA-4, and Protein Kinase Cθ in the Immunological Synapse

2005 • 62 citations

IL-10-Producing Langerhans Cells and Regulatory T Cells Are Responsible for Depressed Contact Hypersensitivity in Grafted Skin

2008 • 52 citations

Cholera toxin inhibits IL-12 production and CD8α+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function

2009 • 52 citations

Cyclic Nucleotides Promote Monocyte Differentiation Toward a DC-SIGN+ (CD209) Intermediate Cell and Impair Differentiation into Dendritic Cells

2003 • 38 citations

Subcellular localization of CD80 receptors is dependent on an intact cytoplasmic tail and is required for CD28-dependent T cell costimulation.

1996 • 32 citations

Expanded murine regulatory T cells: Analysis of phenotype and function in contact hypersensitivity reactions

2007 • 23 citations