The individual regulation of granule protein mRNA levels during neutrophil maturation explains the heterogeneity of neutrophil granules

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Granules of the Human Neutrophilic Polymorphonuclear Leukocyte

1997 • 1,444 citations

Defensins. Natural peptide antibiotics of human neutrophils.

1985 • 1,411 citations

THE DEVELOPMENT OF NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES IN HUMAN BONE MARROW

1971 • 870 citations

Control of exocytosis in early neutrophil activation.

1993 • 366 citations

The Neutral Proteases of Human Granulocytes

1973 • 366 citations

The Human Antibacterial Cathelicidin, hCAP-18, Is Synthesized in Myelocytes and Metamyelocytes and Localized to Specific Granules in Neutrophils

1997 • 356 citations

Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils

1994 • 353 citations

hCAP‐18, a cathelin/pro‐bactenecin‐like protein of human neutrophil specific granules

1995 • 339 citations

Subcellular localization and dynamics of Mac-1 (alpha m beta 2) in human neutrophils.

1993 • 287 citations

Quantitative analysis of the cytosolic free calcium dependency of exocytosis from three subcellular compartments in intact human neutrophils.

1986 • 246 citations

Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation

1995 • 232 citations

Defensin-rich dense granules of human neutrophils

1987 • 209 citations

Isolation and characterization of gelatinase granules from human neutrophils

1994 • 201 citations

Expression of the neutrophil elastase gene during human bone marrow cell differentiation.

1989 • 190 citations

Problems related to the interpretation of autoradiographic data on gene expression using common constitutive transcripts as controls

1993 • 178 citations

Targeting of proteins to granule subsets is determined by timing and not by sorting: The specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells.

1996 • 157 citations

Ultrastructural localization of proteinase 3, the target antigen of anti-cytoplasmic antibodies circulating in Wegener's granulomatosis.

1990 • 156 citations

Altered density, metabolism and surface receptors of eosinophils in eosinophilia.

1982 • 155 citations

Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold

1985 • 146 citations

Analytical Subcellular Fractionation of Human Granulocytes with Reference to the Localization of Vitamin B12-Binding Proteins

1975 • 140 citations

Structural and functional heterogeneity among peroxidase-negative granules in human neutrophils: identification of a distinct gelatinase- containing granule subset by combined immunocytochemistry and subcellular fractionation

1993 • 120 citations

Secretory vesicles are the intracellular reservoir of complement receptor 1 in human neutrophils.

1994 • 117 citations

Regulation of gene expression of myeloperoxidase during myeloid differentiation

1988 • 110 citations

SGP28, a novel matrix glycoprotein in specific granules of human neutrophils with similarity to a human testis‐specific gene product and to a rodent sperm‐coating glycoprotein

1996 • 106 citations

Ultrastructural localization of the CD68 macrophage-associated antigen in human blood neutrophils and monocytes.

1991 • 104 citations

NB4 cells show bilineage potential and an aberrant pattern of neutrophil secondary granule protein gene expression

1994 • 95 citations

The heterogeneity of azurophil granules in neutrophil promyelocytes: immunogold localization of myeloperoxidase, cathepsin G, elastase, proteinase 3, and bactericidal/permeability increasing protein

1994 • 91 citations

Lactoferrin gene promoter: structural integrity and nonexpression in HL60 cells

1992 • 86 citations

Regulation of expression of the CD11b and CD18 subunits of the neutrophil adherence receptor during human myeloid differentiation

1989 • 83 citations

Granulocyte colony-stimulating factor induction of normal human bone marrow progenitors results in neutrophil-specific gene expression

1995 • 82 citations

Identification of an alternative polyadenylation site in the human C3b/C4b receptor (complement receptor type 1) transcriptional unit and prediction of a secreted form of complement receptor type 1.

1988 • 80 citations

Separation of Human Bone Marrow Cells in Density Gradients of Polyvinylpyrrolidone Coated Silica Gel (Percoll)

1980 • 77 citations

Expression Profile of Active Genes in Granulocytes

1998 • 69 citations

Timing, targeting and sorting of azurophil granule proteins in human myeloid cells

1998 • 55 citations

Normal neutrophil differentiation and secondary granule gene expression in the EML and MPRO cell lines.

1998 • 52 citations

Cloning and expression of the cDNA encoding mouse neutrophil gelatinase: demonstration of coordinate secondary granule protein gene expression during terminal neutrophil maturation

1993 • 40 citations

Lysozyme in human neutrophils and plasma. A parameter of myelopoietic activity.

1995 • 38 citations

Transcriptional and posttranscriptional modulation of human neutrophil elastase gene expression

1992 • 34 citations

The subcellular localization of defensins and myeloperoxidase in human neutrophils: immunocytochemical evidence for azurophil granule heterogeneity.

1995 • 29 citations

Neutrophil Secondary-Granule Deficiency as a Hallmark of All-Trans Retinoic Acid–Induced Differentiation of Acute Promyelocytic Leukemia Cells

1997 • 24 citations

Expression of granule protein mRNAs in acute promyelocytic leukemia.

1993 • 23 citations

Ultrastructural cytochemistry of complex carbohydrates in leukocyte granules.

1979 • 21 citations

Unmasking and redistribution of lysosomal sulfated glycoconjugates in phagocytic polymorphonuclear leukocytes.

1986 • 13 citations

Physical procedures for the separation of blood and marrow cells.

1989 • 5 citations

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