Neutrophil Secondary-Granule Deficiency as a Hallmark of All-Trans Retinoic Acid–Induced Differentiation of Acute Promyelocytic Leukemia Cells

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

1990 • 1,349 citations

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991 • 1,298 citations

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments]

1990 • 1,224 citations

All-trans-Retinoic Acid in Acute Promyelocytic Leukemia

1997 • 1,090 citations

THE DEVELOPMENT OF NEUTROPHILIC POLYMORPHONUCLEAR LEUKOCYTES IN HUMAN BONE MARROW

1971 • 870 citations

Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17

1990 • 650 citations

The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

1993 • 602 citations

Acute promyelocytic leukemia: from genetics to treatment

1994 • 474 citations

Evidence for a 15; 17 translocation in every patient with acute promyelocytic leukemia

1984 • 441 citations

All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship

1990 • 390 citations

Acute promyelocytic leukemia: from genetics to treatment

1994 • 384 citations

Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.

1991 • 253 citations

A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage.

1993 • 233 citations

"Microgranular" acute promyelocytic leukemia: a distinct clinical, ultrastructural, and cytogenetic entity

1980 • 196 citations

Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells

1991 • 178 citations

Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold

1985 • 146 citations

Acute promyelocytic leukaemia: a study of 39 cases with identification of a hyperbasophilic microgranular variant

1982 • 139 citations

Isolation of lactoferrin cDNA from a human myeloid library and expression of mRNA during normal and leukemic myelopoiesis

1987 • 90 citations

Lactoferrin gene promoter: structural integrity and nonexpression in HL60 cells

1992 • 86 citations

Retinoic acid and granulocyte colony-stimulating factor synergistically induce leukocyte alkaline phosphatase in acute promyelocytic leukemia cells

1994 • 70 citations

Retinoic acid and granulocyte colony-stimulating factor synergistically induce leukocyte alkaline phosphatase in acute promyelocytic leukemia cells

1994 • 62 citations

Abnormalities in granule formation in acute myelogenous leukemia

1977 • 59 citations

The association of nuclear blebs with aneuploidy in human acute leukemia.

1974 • 54 citations

Glycosaminoglycans in human neutrophils and leukemic myeloblasts: ultrastructural, cytochemical, immunologic, and biochemical characterization

1983 • 53 citations

Development of the granule population in neutrophil granulocytes from human bone marrow

1983 • 47 citations

Immunocytochemical localization of lactoferrin in human neutrophils

1987 • 32 citations

Identification of a subpopulation of primary granules in human neutrophils based upon maturation and distribution. Study by transmission electron microscopy cytochemistry and high voltage electron microscopy of whole cell preparations.

1985 • 31 citations

Abnormal Neutrophils in Acute Myelogenous Leukemia: Identification of Subpopulations Based on Analysis of Azurophil and Specific Granules

1975 • 28 citations

Pseudo-Chediak-Higashi anomaly in a case of acute myeloid leukemia: electron microscopic studies

1979 • 28 citations

Peroxidase-containing microgranules in human neutrophils: physical, morphological, cytochemical, and secretory properties

1987 • 28 citations

Probing the pathobiology of response to all-trans retinoic acid in acute promyelocytic leukemia: premature chromosome condensation/fluorescence in situ hybridization analysis

1996 • 25 citations

Formation of lipid inclusions in normal human leukocytes

1977 • 24 citations

Ultrastructural localization of peroxidase activity in developing neutrophil granulocytes from human bone marrow

1986 • 24 citations

Unusual Configurations of Endoplasmic Reticulum in Cells of Acute Promyelocytic Leukemia

1978 • 22 citations

Ultrastructural cytochemistry of complex carbohydrates in leukocyte granules.

1979 • 21 citations

Electron microscopic and peroxidase cytochemical analysis of pink pseudo-Chediak-Higashi granules in acute myelogenous leukemia.

1980 • 16 citations

Lactoferrin-deficient neutrophil polymorphonuclear leucocytes in leukaemias: a semiquantitative and ultrastructural cytochemical study.

1983 • 15 citations

Quantitative cytochemistry of blood neutrophils in acute myeloid leukaemia

1983 • 13 citations

Differentiation induction of blast cells in two cases of childhood acute megakaryoblastic leukemia in vitro by interleukin‐3 and interleukin‐6: An ultrastructural cytochemical study

1991 • 10 citations