An autocrine loop for vascular endothelial growth factor is established in prostate cancer cells generated after prolonged treatment with interleukin 6

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Interleukin 6 Induces the Expression of Vascular Endothelial Growth Factor

1996 • 1,031 citations

Expression of Vascular Endothelial Growt Factor and Its Receptors fit and KDR in Ovarian Carcinoma

1995 • 469 citations

Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells.

2001 • 440 citations

Interleukin-6 Is an Autocrine Growth Factor in Human Prostate Cancer

2001 • 337 citations

Conflict of interest statement

2003 • 303 citations

Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS–Kaposi sarcoma

1997 • 293 citations

Interleukin-6: A candidate mediator of human prostate cancer morbidity

1995 • 293 citations

Vascular Endothelial Growth Factor (VEGF) Expression in Human Prostate Cancer: In Situ and in Vitro Expression of VEGF by Human Prostate Cancer Cells

1997 • 286 citations

Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells

1998 • 282 citations

Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancer

1999 • 251 citations

Characterization of the role of IL-6 in the progression of prostate cancer

1999 • 226 citations

Androgens regulate vascular endothelial growth factor content in normal and malignant prostatic tissue.

1997 • 215 citations

Expression of vascular endothelial growth factor receptors in human prostate cancer

1999 • 202 citations

De novo expression of vascular endothelial growth factor in human pancreatic cancer: Evidence for an autocrine mitogenic loop

2000 • 184 citations

A potential autocrine role for vascular endothelial growth factor in prostate cancer.

2002 • 178 citations

Signal Transducer and Activator of Transcription 3 Is Required for Glycoprotein 130-mediated Induction of Vascular Endothelial Growth Factor in Cardiac Myocytes

2000 • 158 citations

Interleukin-6 regulates androgen receptor activity and prostate cancer cell growth

2002 • 126 citations

Prostate cancer cells (LNCaP) generated after long-term interleukin 6 (IL-6) treatment express IL-6 and acquire an IL-6 partially resistant phenotype.

2001 • 123 citations

Anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 production.

2002 • 121 citations

Highly metastatic human prostate cancer growing within the prostate of athymic mice overexpresses vascular endothelial growth factor.

1999 • 115 citations

Anti‐interleukin‐6 monoclonal antibody induces regression of human prostate cancer xenografts in nude mice

2001 • 114 citations

Vascular Endothelial Growth Factor-Mediated Autocrine Stimulation of Prostate Tumor Cells Coincides with Progression to a Malignant Phenotype

2001 • 108 citations

Vascular Endothelial Growth Factor Is Up-Regulatedin Vitroandin Vivoby Androgens

1998 • 105 citations

Antibody to vascular endothelial growth factor slows growth of an androgen-independent xenograft model of prostate cancer.

2002 • 104 citations

Impact of Vascular Endothelial Growth Factor-C and -D Expression in Human Pancreatic Cancer

2004 • 102 citations

Prostaglandin E2 Stimulates Prostatic Intraepithelial Neoplasia Cell Growth through Activation of the Interleukin-6/GP130/STAT-3 Signaling Pathway

2002 • 102 citations

Accelerated in Vivo Growth of Prostate Tumors that Up-Regulate Interleukin-6 Is Associated with Reduced Retinoblastoma Protein Expression and Activation of the Mitogen-Activated Protein Kinase Pathway

2003 • 99 citations

Stromal cells from human benign prostate hyperplasia produce a growth-inhibitory factor for LNCaP prostate cancer cells, identified as interleukin-6

1996 • 98 citations

TESTOSTERONE INDUCES VASCULAR ENDOTHELIAL GROWTH FACTOR SYNTHESIS IN THE VENTRAL PROSTATE IN CASTRATED RATS

1999 • 93 citations

Expression of Vascular Endothelial Growth Factor (VEGF) and VEGF Receptor Flk-1 in Benign, Premalignant, and Malignant Prostate Tissue

2001 • 77 citations

Effect of Interleukins on UGT2B15 and UGT2B17 Steroid Uridine Diphosphate-Glucuronosyltransferase Expression and Activity in the LNCaP Cell Line¹

1998 • 56 citations

Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible factor-1?

2003 • 48 citations

17α-Estradiol-induced VEGF-A expression in rat pituitary tumor cells is mediated through ER independent but PI3K-Akt dependent signaling pathway

2003 • 40 citations

Effect of Interleukins on UGT2B15 and UGT2B17 Steroid Uridine Diphosphate-Glucuronosyltransferase Expression and Activity in the LNCaP Cell Line

1998 • 22 citations

True

2000 • 18 citations