Characterization of structurally distinct, isoform-selective phosphoinositide 3′-kinase inhibitors in combination with radiation in the treatment of glioblastoma

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase

2007 • 1,176 citations

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

2006 • 1,119 citations

Signaling by Distinct Classes of Phosphoinositide 3-Kinases

1999 • 861 citations

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

2006 • 587 citations

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

1998 • 526 citations

The Akt/PKB pathway: molecular target for cancer drug discovery

2005 • 495 citations

Intrinsic radiosensitivity of human cell lines is correlated with radioresponsiveness of human tumors: Analysis of 101 published survival curves

1985 • 488 citations

Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

2006 • 388 citations

The Prognostic Significance of Phosphatidylinositol 3-Kinase Pathway Activation in Human Gliomas

2004 • 368 citations

Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.

2002 • 358 citations

Clonogenic Cell Survival Assay

2005 • 310 citations

Use of an Orthotopic Xenograft Model for Assessing the Effect of Epidermal Growth Factor Receptor Amplification on Glioblastoma Radiation Response

2006 • 268 citations

Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma.

2001 • 268 citations

Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene.

1996 • 267 citations

Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.

1997 • 215 citations

Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy.

2002 • 200 citations

PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.

1997 • 199 citations

The p53 gene and its role in human brain tumors

1995 • 188 citations

The conditional probability of survival of patients with primary malignant brain tumors

1999 • 185 citations

Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002

2003 • 179 citations

Selective Inhibition of Ras, Phosphoinositide 3 Kinase, and Akt Isoforms Increases the Radiosensitivity of Human Carcinoma Cell Lines

2005 • 177 citations

Dysregulation of PTEN and protein kinase B is associated with glioma histology and patient survival.

2002 • 177 citations

Computer Programs for the Analysis of Cellular Survival Data

1987 • 171 citations

Genetic alterations in adult diffuse glioma: occurrence, significance, and prognostic implications

2000 • 163 citations

PDK2: A Complex Tail in One Akt

2001 • 126 citations

Studies on the Mechanism of Phosphatidylinositol 3-Kinase Inhibition by Wortmannin and Related Analogs

1996 • 116 citations

PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas

2005 • 84 citations

Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells

2004 • 70 citations

Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity

2006 • 62 citations

An antisense oligonucleotide targeted to human Ku86 messenger RNA sensitizes M059K malignant glioma cells to ionizing radiation, bleomycin, and etoposide but not DNA cross-linking agents.

2002 • 60 citations

Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells

2003 • 52 citations

Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism

2005 • 49 citations

Genetic alterations in adult diffuse glioma occurrence significance and prognostic implications

2000 • 9 citations

Activation of the Phosphatidylinositol‐3′‐Kinase/Protein Kinase B‐Dependent Antiapoptotic Pathway Plays an Important Role in the Development of Radioresistance of Human Glioma Cells

2002 • 6 citations

Adjuvant therapy for brain tumor.

1980 • 2 citations