Impact of DNA ligase IV on the fidelity of end joining in human cells

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency

2001 • 893 citations

DNA Ligase IV Mutations Identified in Patients Exhibiting Developmental Delay and Immunodeficiency

2001 • 529 citations

Molecular mechanisms of DNA double-strand break repair

1998 • 515 citations

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.

1996 • 492 citations

Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

1996 • 478 citations

Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

1993 • 457 citations

Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends

2000 • 387 citations

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

1999 • 386 citations

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

1992 • 367 citations

5 DNA Breakage and Repair

1998 • 363 citations

DNA Ligase IV Is Essential for V(D)J Recombination and DNA Double-Strand Break Repair in Human Precursor Lymphocytes

1998 • 345 citations

DNA end-joining catalyzed by human cell-free extracts

1998 • 291 citations

Association of DNA Polymerase μ (pol μ) with Ku and Ligase IV: Role for pol μ in End-Joining Double-Strand Break Repair

2002 • 287 citations

Mutations in Two Ku Homologs Define a DNA End-Joining Repair Pathway in Saccharomyces cerevisiae

1996 • 275 citations

Double-strand break repair in Ku86- and XRCC4-deficient cells

1998 • 235 citations

Chromosomal double-strand break repair in Ku80-deficient cells.

1996 • 191 citations

The Saccharomyces cerevisiae Ku Autoantigen Homologue Affects Radiosensitivity Only in the Absence of Homologous Recombination

1996 • 189 citations

DNA binding of Xrcc4 protein is associated with V(D)Jrecombination but not with stimulation of DNA ligase IV activity

1999 • 179 citations

Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe

2001 • 175 citations

Terminal deoxynucleotidyl transferase and repertoire development

2000 • 165 citations

Mechanistic Constraints on Diversity in Human V(D)J Recombination

1996 • 165 citations

Crystal Structure of Eukaryotic DNA Ligase–Adenylate Illuminates the Mechanism of Nick Sensing and Strand Joining

2000 • 156 citations

Cellular and Biochemical Impact of a Mutation in DNA Ligase IV Conferring Clinical Radiosensitivity

2001 • 125 citations

Assay for gene mutation in a human lymphoblast line, AHH-1, competent for xenobiotic metabolism

1984 • 113 citations

A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining

2002 • 96 citations

Defective repair of DNA double-strand breaks and chromosome damage in fibroblasts from a radiosensitive leukemia patient.

1995 • 82 citations

Fanconi anemia C gene product plays a role in the fidelity of blunt DNA end-joining

1998 • 81 citations

Joining of linear plasmid DNA is reduced and error-prone in Bloom's syndrome cells.

1989 • 68 citations

The influence of DNA double-strand break structure on end-joining in human cells

2001 • 56 citations

Modulation of Terminal Deoxynucleotidyltransferase Activity by the DNA-Dependent Protein Kinase

1999 • 53 citations

Unequal Signal and Coding Joint Formation in Human V(D)J Recombination

1993 • 52 citations

A DNA double-strand break defective fibroblast cell line (180BR) derived from a radiosensitive patient represents a new mutant phenotype.

1997 • 49 citations

The fidelity of double strand breaks processing is impaired in complementation groups B and D of fanconi anemia, a genetic instability syndrome

1997 • 46 citations

Molecular mechanisms of DNA double strand break repair

1999 • 29 citations

Abnormal processing of transfected plasmid DNA in cells from patients with ataxia telangiectasia

1992 • 28 citations

Unequal signal and coding joint formation in human V(D)J recombination.

1993 • 25 citations

Reduced joining of DNA double strand breaks with an abnormal mutation spectrum in rodent mutants of DNA-PKcs and Ku80

1998 • 23 citations

Terminal deoxynucleotidyl transferase and repertoire development

2000 • 10 citations