Regulation of CD69 expression on human natural killer cells: differential involvement of protein kinase C and protein tyrosine kinases

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Biology of Natural Killer Cells

1989 • 2,970 citations

T cell activation via Leu-23 (CD69).

1989 • 296 citations

Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes.

1988 • 283 citations

Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen.

1988 • 244 citations

Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering. Requirement for receptor cross-linking, prolonged elevation of intracellular [Ca++] and stimulation of protein kinase C.

1989 • 226 citations

CD69-mediated pathway of lymphocyte activation: anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor alpha/beta.

1991 • 219 citations

Fc gamma R(CD16) interaction with ligand induces Ca2+ mobilization and phosphoinositide turnover in human natural killer cells. Role of Ca2+ in Fc gamma R(CD16)-induced transcription and expression of lymphokine genes.

1989 • 208 citations

Protein kinase C is required for responses to T cell receptor ligands but not to interleukin-2 in T cells

1988 • 183 citations

Mechanism of Interleukin-2 Signaling: Mediation of Different Outcomes by a Single Receptor and Transduction Pathway

1989 • 148 citations

Activation of natural killer cells via the p75 interleukin 2 receptor.

1989 • 133 citations

Differential responses to interleukin 2 define functionally distinct subsets of human natural killer cells

1992 • 130 citations

CD69 in resting and activated T lymphocytes. Its association with a GTP binding protein and biochemical requirements for its expression.

1991 • 130 citations

Tyrosine phosphorylation of the Fc gamma RIII(CD16): zeta complex in human natural killer cells. Induction by antibody-dependent cytotoxicity but not by natural killing.

1991 • 129 citations

CD69 is expressed on platelets and mediates platelet activation and aggregation.

1990 • 107 citations

Engagement of the natural killer cell IgG Fc receptor results in tyrosine phosphorylation of the zeta chain.

1991 • 102 citations

Tyrosine phosphorylation provides an early and requisite signal for the activation of natural killer cell cytotoxic function.

1991 • 93 citations

Constitutive expression of a phosphorylated activation antigen (Leu 23) by CD3bright human thymocytes.

1988 • 80 citations

Human T cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor AP-1.

1992 • 80 citations

Biochemical and Molecular Events Associated with Interleukin 2 Regulation of Lymphocyte Proliferation

1986 • 70 citations

Human T cell activation. IV. T cell activation and proliferation via the early activation antigen EA 1.

1989 • 66 citations

A role for protein tyrosine kinase activity in natural cytotoxicity as well as antibody-dependent cellular cytotoxicity. Effects of herbimycin A.

1992 • 64 citations

MLR3 molecule is an activation antigen shared by human B, T lymphocytes and T cell precursors

1989 • 60 citations

Phosphatidylinositol metabolism accompanies early activation events in tumor target cell-stimulated human natural killer cells

1988 • 59 citations

Protein tyrosine phosphorylation and p56lck modification in IL-2 or phorbol ester-activated human natural killer cells.

1990 • 52 citations

Natural killer cells

1992 • 49 citations

Expression and function of AIM, an activation inducer molecule of human lymphocytes, is dependent on the activation of protein kinase C

1989 • 48 citations

Natural killer susceptibility is independent of HLA class I antigen expression on cell lines obtained from human solid tumors

1990 • 46 citations

Fc gamma receptor signal transduction in natural killer cells. Coupling to phospholipase C via a G protein-independent, but tyrosine kinase-dependent pathway.

1991 • 42 citations

CD2 is functionally linked to the ζ‐natural killer receptor complex

1991 • 41 citations

The 28-kDa/32-kDa activation antigen EA 1. Further characterization and signal requirements for its expression.

1988 • 41 citations

Phosphoinositide breakdown and evidence for protein kinase C involvement during human NK killing

1988 • 40 citations

Expression of lineage‐restricted protein tyrosine kinase genes in human natural killer cells

1991 • 28 citations

Characterization of a subset of human B lymphocytes interacting with natural killer cells.

1991 • 13 citations