The molecular defences against reactive oxygen species in yeast

Free radicals in biology and medicine

1991 • 17,840 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

[37] Carbonyl assays for determination of oxidatively modified proteins

1994 • 2,605 citations

Thioredoxin-dependent peroxide reductase from yeast.

1994 • 940 citations

The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene.

1994 • 511 citations

YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides.

1994 • 472 citations

A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions.

1993 • 470 citations

Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.

1991 • 369 citations

GSH1, which encodes gamma-glutamylcysteine synthetase, is a target gene for yAP-1 transcriptional regulation.

1994 • 310 citations

Rapid and sensitive pollutant detection by induction of heat shock gene-bioluminescence gene fusions

1994 • 300 citations

Cloning, sequencing, and mutation of thiol-specific antioxidant gene of Saccharomyces cerevisiae

1993 • 299 citations

DNA and Free Radicals

1993 • 291 citations

MAC1, a nuclear regulatory protein related to Cu-dependent transcription factors is involved in Cu/Fe utilization and stress resistance in yeast.

1993 • 274 citations

The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity.

1995 • 265 citations

Redox redux: The control of oxidative stress responses

1991 • 242 citations

Mutations in PMR1 suppress oxidative damage in yeast cells lacking superoxide dismutase

1995 • 241 citations

Saccharomyces cerevisiae has distinct adaptive responses to both hydrogen peroxide and menadione

1992 • 234 citations

Stress tolerance and membrane lipid unsaturation in Saccharomyces cerevisiae grown aerobically or anaerobically

1994 • 232 citations

Yeast and mammalian metallothioneins functionally substitute for yeast copper-zinc superoxide dismutase.

1993 • 230 citations

Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCF1.

1994 • 214 citations

Stress response of yeast

1993 • 211 citations

The PAR1 (YAP1/SNQ3) gene of Saccharomyces cerevisiae, ac-jun homologue, is involved in oxygen metabolism

1992 • 209 citations

Inducibility of the response of yeast cells to peroxide stress

1992 • 207 citations

The role of the YAP1 and YAP2 genes in the regulation of the adaptive oxidative stress responses of Saccharomyces cerevisiae

1995 • 200 citations

ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene.

1991 • 199 citations

Yeast bZip proteins mediate pleiotropic drug and metal resistance.

1993 • 191 citations

Isolation and characterization of the ZWF1 gene of Saccharomyces cerevisiae, encoding glucose-6-phosphate dehydrogenase

1990 • 179 citations

Is hydroxyl radical generated by the Fenton reaction in vivo?

1985 • 173 citations

Saccharomyces Cerevisiae has an Inducible Response to Menadione which differs from that to Hydrogen Peroxide

1993 • 151 citations

Absence of electron transport (Rho 0 state) restores growth of a manganese-superoxide dismutase-deficient Saccharomyces cerevisiae in hyperoxia. Evidence for electron transport as a major source of superoxide generation in vivo.

1993 • 151 citations

Induction of major heat-shock proteins of Saccharomyces cerevisiae, including plasma membrane Hsp30, by ethanol levels above a critical threshold

1994 • 150 citations

Analysis of Saccharomyces cerevisiae proteins induced by peroxide and superoxide stress

1994 • 134 citations

Yap1p, a yeast transcriptional activator that mediates multidrug resistance, regulates the metabolic stress response.

1994 • 132 citations

Molecular cloning of the γ‐glutamylcysteine synthetase gene of Saccharomyces cerevisiae

1991 • 131 citations

Mutants of Saccharomyces cerevisiae sensitive to oxidative and osmotic stress

1995 • 106 citations

The vacuolar H+-ATPase of Saccharomyces cerevisiae is required for efficient copper detoxification, mitochondrial function, and iron metabolism

1993 • 102 citations

Stress-induced transcriptional activation mediated by YAP1 and YAP2 genes that encode the Jun family of transcriptional activators in Saccharomyces cerevisiae

1994 • 95 citations

Transcriptional activation mediated by the yeast AP-1 protein is required for normal cadmium tolerance.

1994 • 94 citations

Acquisition of Ethanol Tolerance in Saccharomyces cerevisiae: The Key Role of the Mitochondrial Superoxide Dismutase

1993 • 89 citations

Overexpression of YAP2, coding for a new yAP protein, and YAP1 in Saccharomyces cerevisiae alleviates growth inhibition caused by 1,10-phenanthroline.

1993 • 83 citations

Polyubiquitin gene expression contributes to oxidative stress resistance in respiratory yeast (Saccharomyces cerevisiae)

1994 • 81 citations

Oxidative mutagens induce intrachromosomal recombination in yeast

1994 • 77 citations

The requirement for yeast superoxide dismutase is bypassed through mutations in BSD2, a novel metal homeostasis gene.

1994 • 71 citations

Regulation of manganese superoxide dismutase in Saccharomyces cerevisiae

1988 • 60 citations

Oxygen toxicity in a polyamine-depleted spe2 delta mutant of Saccharomyces cerevisiae.

1993 • 57 citations

The role of glutathione biosynthesis in heavy metal resistance in the fission yeastSchizosaccharomyces pombe

1994 • 55 citations

Complementation of DNA repair‐deficient Escherichia coli by the yeast Apn1 apurinic/apyrimidinic endonuclease gene

1991 • 52 citations

Regulation of Cu,Zn‐ and Mn‐superoxide dismutase transcription in Saccharomyces cerevisiae

1993 • 47 citations

Absence of Electron Transport (Rho' State) Restores Growth of a Manganese-Superoxide Dismutase-deficient Saccharomyces cerevisiae in Hyperoxia

1993 • 41 citations

As We Live And Breathe: Free Radicals and Aging

1994 • 35 citations

The methionine sulphoxide reductase activity of the yeast dimethyl sulphoxide reductase system

1985 • 20 citations

Mechanisms of Oxygen Radiosensitization in Irradiated Yeast

1993 • 19 citations

Lipid hydroperoxide‐resistance gene in Saccharomyces cerevisiae: utilization as a selectable marker gene for yeast transformation

1993 • 7 citations

The role of glutathione biosynthesis in heavy metal resistance in the fission yeast Schizosaccharomyces pombe

1994 • 6 citations

The methionine sulphoxide reductase activity of the yeast dimethyl sulphoxide reductase system

1985 • 3 citations