Prospects for Development of a Treponemal Vaccine

IMMOBILIZATION OF TREPONEMA PALLIDUM IN VITRO BY ANTIBODY PRODUCED IN SYPHILITIC INFECTION

1949 • 386 citations

INOCULATION SYPHILIS IN HUMAN VOLUNTEERS

1956 • 268 citations

Biology of the treponematoses

1957 • 225 citations

Molecular characterization of receptor binding proteins and immunogens of virulent Treponema pallidum.

1980 • 146 citations

Therapy for Incubating Syphilis

1971 • 129 citations

Biology of the treponematoses based on studies carried out at the International Treponematosis Laboratory Center of the Johns Hopkins University under the auspices of the World Health Organization.

1957 • 124 citations

Demonstration of the in Vitro Phagocytosis of Treponema Pallidum by Rabbit Peritoneal Macrophages

1978 • 122 citations

Characterization of the attachment of Treponema pallidum (Nichols strain) to cultured mammalian cells and the potential relationship of attachment to pathogenicity

1977 • 122 citations

Characterization of lymphocyte responsiveness in early experimental syphilis. II. Nature of cellular infiltration and Treponema pallidum distribution in testicular lesions.

1980 • 122 citations

Treponema pallidum (Nichols strain) in tissue cultures: cellular attachment, entry, and survival

1975 • 122 citations

Humoral immune response in human syphilis to polypeptides of Treponema pallidum.

1982 • 115 citations

Immunity in experimental syphilis. VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by -irradiation.

1973 • 115 citations

Parasitism by Virulent Treponema pallidum of Host Cell Surfaces

1977 • 110 citations

Identification of Treponema pallidum antigens: comparison with a nonpathogenic treponeme.

1982 • 105 citations

Surface Characterization of Virulent Treponema pallidum

1980 • 92 citations

Humoral immunity in experimental syphilis. I. The demonstration of resistance conferred by passive immunization.

1976 • 87 citations

Identification and preliminary characterization of Treponema pallidum protein antigens expressed in Escherichia coli

1983 • 86 citations

Murine monoclonal antibodies specific for virulent Treponema pallidum (Nichols)

1982 • 85 citations

Molecular cloning and expression of Treponema pallidum DNA in Escherichia coli K-12

1983 • 83 citations

Humoral immunity in experimental syphilis. II. The relationship of neutralizing factors in immune serum to acquired resistance.

1976 • 83 citations

Humoral immune response in experimental syphilis to polypeptides of Treponema pallidum.

1983 • 73 citations

Expression of Treponema pallidum Antigens in Escherichia coli

1982 • 72 citations

Comparison of major protein antigens and protein profiles of Treponema pallidum and Treponema pertenue

1983 • 68 citations

Molecular analysis of immunoglobulins M and G immune response to protein antigens of Treponema pallidum in human syphilis

1984 • 63 citations

Molecular basis of immunological cross-reactivity between Treponema pallidum and Treponema pertenue

1983 • 62 citations

Host Response to Treponema pallidum in Intradermally-Infected Rabbits: Evidence for Persistence of Infection at Local and Distant Sites

1980 • 60 citations

Natural treponematosis of the African primate.

1969 • 60 citations

Characterization of monoclonal antibodies to Treponema pallidum.

1985 • 60 citations

PROTECTIVE ANTIBODIES IN THE SERUM OF SYPHILITIC RABBITS

1939 • 53 citations

A histopathologic and immunologic study of the course of syphilis in the experimentally infected rabbit. Demonstration of long-lasting cellular immunity.

1980 • 53 citations

How infectious is syphilis?

1983 • 53 citations

Immunity to Syphilis I. Passive Transfer in Rabbits with Hyperimmune Serum

1973 • 52 citations

Experimental syphilitic orchitis in rabbits: ultrastructural appearance of Treponema pallidum during phagocytosis and dissolution by macrophages in vivo.

1982 • 51 citations

Effect of cortisone administration on host-parasite relationships in early experimental syphilis.

1981 • 48 citations

Molecular characterization of common treponemal antigens

1983 • 46 citations

An electron microscopic study of a syphilitic chancre. Engulfment of Treponema pallidum by plasma cells.

1970 • 43 citations

Immunogenic properties of the protein component of Treponema pallidum.

1969 • 40 citations

Serial ultrathin sectioning demonstrating the intracellularity of T. Pallidum. An electron microscopic study.

1972 • 40 citations

Analysis of serum IgG against Treponema pallidum protein antigens in experimentally infected rabbits.

1981 • 40 citations

Immunity to syphilis: passive transfer in rabbits using serial doses of immune serum

1976 • 37 citations

Attempt to protect rabbits against experimental syphilis by passive immunization.

1973 • 36 citations

Activation of macrophages by products of lymphocytes from normal and syphilitic rabbits

1982 • 35 citations

Experimental Syphilis in the Rabbit: Passive Transfer of Immunity with Immunoglobulin G from Immune Serum

1979 • 35 citations

Effects of passive immunization on experimental syphilis in the rabbit.

1973 • 34 citations

Acquired resistance of hamsters to challenge with homologous and heterologous virulent treponemes

1982 • 29 citations

LSH hamster model of syphilitic infection

1980 • 27 citations

Immune serum confers protection against syphilitic infection on hamsters

1983 • 27 citations

THE ANTIBODY RESPONSE IN RABBITS TO KILLED SUSPENSIONS OF PATHOGENIC T. PALLIDUM

1948 • 26 citations

Artificial immunization of rabbits against syphilis. I. Effect of increasing doses of treponemes given by the intramuscular route.

1969 • 25 citations

CROSS IMMUNITY IN EXPERIMENTAL SYPHILIS, YAWS, AND VENEREAL SPIROCHETOSIS OF RABBITS123

1947 • 24 citations

Use of CB hamsters in the study of Treponema pertenue.

1979 • 23 citations

Passive transfer of resistance to frambesial infection in hamsters

1978 • 23 citations

Electron microscopy of Treponema pallidum occurring in a human primary lesion

1969 • 20 citations

Limited protection of rabbits against infection with Treponema pallidum by immune rabbit sera.

1979 • 19 citations

Molecular characterization of Treponema pallidum proteins responsible for the human immune response to syphilis

1982 • 18 citations

PROTECTIVE ANTIBODIES IN THE SERUM OF SYPHILITIC PATIENTS12

1948 • 18 citations

STUDIES ON THE PREVENTIVE INOCULATION AGAINST SYPHILIS

1951 • 14 citations

Inability of spleen cells from chancre-immune rabbits to confer immunity to challenge with Treponema pallidum

1977 • 14 citations

Passive transfer of immunity to experimental syphilis in rabbits by immune lymphocytes.

1975 • 13 citations

Resistance and serological changes in rabbits immunized with virulent Treponema pallidum sonicate.

1971 • 13 citations

THE RESISTANCE OF YAWS AND SYPHILIS PATIENTS TO REINOCULATION WITH YAWS SPIROCHETES1

1936 • 13 citations

Development of monoclonal antibodies that recognize Treponema pallidum

1983 • 12 citations

Cobra venom factor abrogates passive humoral resistance to syphilitic infection in hamsters

1984 • 10 citations

Ability of enriched immune T cells to confer resistance in hamsters to infection with Treponema pertenue

1979 • 10 citations

Treponemicidal activity of supernatants from cultures of sensitized lymphocytes.

1981 • 10 citations

Attempted immunization of rabbits against syphilis with killed Treponema pallidum and adjuvants.

1947 • 9 citations

Potential for vaccines for venereal diseases.

1976 • 9 citations

Sequential changes in susceptibility to Treponema pallidum of rabbits previously infected with Treponema paraluis-cuniculi

1981 • 8 citations

Attempts at immunization against syphilis with avirulent Treponemma pallidum.

1970 • 7 citations

Immunization of Rabbits with Spirochaeta aurantia Does Not Induce Resistance to Treponema pallidum

1984 • 7 citations

Immunity in syphilis. Studies in active immunity.

1976 • 7 citations

Immunochemical Studies of the Reiter Spirochete.

1951 • 6 citations

Experimental syphilis vaccines in rabbits. I. Differential protection with an adjuvant spectrum.

1976 • 5 citations

Inability of immune cells treated with anti-thymocyte serum to confer on hamsters resistance to cutaneous infection with Treponema pertenue

1979 • 3 citations

Preventive Immunization against Treponematous Infections and Experiments which indicate the Possibility of Antitreponematous Immunization.

1930 • 3 citations