DNA Methylation and Gene Expression

Expression of a single transfected cDNA converts fibroblasts to myoblasts

1987 • 3,373 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Amount and distribution of 5-methylcytosine in human DNA from different types of tissues or cells

1982 • 1,002 citations

Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).

1981 • 873 citations

Sequence specificity of methylation in higher plant DNA

1981 • 719 citations

Reactivation of an Inactive Human X Chromosome: Evidence for X Inactivation by DNA Methylation

1981 • 711 citations

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

1980 • 634 citations

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation.

1989 • 554 citations

De novo methylation and expression of retroviral genomes during mouse embryogenesis

1982 • 524 citations

The nucleotide sequence of the human β-globin gene

1980 • 502 citations

5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β⁺Thalassemia

1982 • 496 citations

Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation

1981 • 475 citations

DNA methylation controls the inducibility of the mouse metallothionein-I gene in lymphoid cells

1981 • 464 citations

DNA methylation and the regulation of globin gene expression

1983 • 451 citations

Substrate and sequence specificity of a eukaryotic DNA methylase

1982 • 441 citations

Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1.

1981 • 388 citations

Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring

1982 • 379 citations

The somatic replication of DNA methylation

1981 • 368 citations

Temporal order of chromatin structural changes associated with activation of the major chicken vitellogenin gene

1983 • 366 citations

Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation

1987 • 363 citations

α-globin-gene switching during the development of chicken embryos: Expression and chromosome structure

1981 • 353 citations

De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells.

1982 • 299 citations

A dominant role for DNA secondary structure in forming hypersensitive structures in chromatin

1983 • 273 citations

In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells.

1982 • 271 citations

DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning.

1981 • 231 citations

Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis.

1986 • 224 citations

The absence of detectable methylated bases in Drosophila melanogaster DNA

1982 • 211 citations

Distribution of 5-methylcytosine in chromatin.

1977 • 196 citations

Methylation of foreign DNA sequences in eukaryotic cells.

1980 • 190 citations

Delayed de novo methylation in teratocarcinoma suggests additional tissue-specific mechanisms for controlling gene expression

1983 • 187 citations

The regulated expression of β-globin genes introduced into mouse erythroleukemia cells

1983 • 186 citations

Expression of a cloned adenovirus gene is inhibited by in vitro methylation.

1982 • 184 citations

Unusual methylation pattern of the α2(I) collagen gene

1982 • 177 citations

Tissue-specific DNA methylation in a cluster of rabbit beta-like globin genes.

1980 • 172 citations

Activation of globin genes during chicken development

1981 • 164 citations

Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine.

1982 • 149 citations

Pattern of methylation of two genes coding for housekeeping functions.

1983 • 148 citations

5-Azacytidine-Induced Reactivation of a Herpes Simplex Thymidine Kinase Gene

1982 • 144 citations

Estrogen induces a demethylation at the 5' end region of the chicken vitellogenin gene.

1982 • 142 citations

Active gene sequences are undermethylated.

1981 • 139 citations

Expression of the chloramphenicol acetyltransferase gene in mammalian cells under the control of adenovirus type 12 promoters: effect of promoter methylation on gene expression.

1983 • 139 citations

Muscle-specific activation of a methylated chimeric actin gene

1986 • 135 citations

Undermethylation at the 5′ end of the albumin gene is necessary but not sufficient for albumin production by rat hepatoma cells in culture

1982 • 124 citations

Differences in the DNA of the inactive X chromosomes of fetal and extraembryonic tissues of mice

1983 • 123 citations

Tissue-specific expression of a cloned chick δ-crystallin gene in mouse cells

1983 • 121 citations

The effect of sequence specific DNA methylation on restriction endonuclease cleavage

1981 • 120 citations

Expression and methylation of the mouse alpha-fetoprotein gene in embryonic, adult, and neoplastic tissues.

1982 • 119 citations

Regulated expression of the human β-globin gene family in murine erythroleukaemia cells

1983 • 112 citations

Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycle.

1985 • 111 citations

Effect of the B--Z transition in poly(dG-m5dC) . poly(dG-m5dC) on nucleosome formation.

1982 • 110 citations

Derepression of genes on the human inactive X chromosome: Evidence for differences in locus-specific rates of derepression and rates of transfer of active and inactive genes after DNA-mediated transformation

1982 • 110 citations

Murine erythroleukemia cell differentiation: DNase I hypersensitivity and DNA methylation near the globin genes

1982 • 110 citations

Inactive X chromosome DNA does not function in DNA-mediated cell transformation for the hypoxanthine phosphoribosyltransferase gene.

1980 • 106 citations

5-methylcytosine is localized in nucleosomes that contain histone H1.

1983 • 97 citations

Organization of 5-methylcytosine in chromosomal DNA

1978 • 95 citations

Unusual properties of the DNA from Xanthomonas phage XP-12 in which 5-methylcytosine completely replaces cytosine

1975 • 93 citations

The bacteriopbage λ O replication protein: isolation and characterization of the amplified initiator

1983 • 88 citations

In contrast to other Xenopus genes the estrogen-inducible vitellogenin genes are expressed when totally methylated

1983 • 87 citations

Methylation of simian virus 40 Hpa II site affects late, but not early, viral gene expression.

1982 • 85 citations

Studies on gene control regions XII. The functional significance of a Lac operator constitutive mutation

1979 • 84 citations

Expression of a chicken lysozyme recombinant gene is regulated by progesterone and dexamethasone after microinjection into oviduct cells

1982 • 83 citations

Changes in methylation pattern of albumin and α-fetoprotein genes in developing rat liver and neoplasia

1983 • 70 citations

Distribution of 5-methylcytosine in the DNA of somatic and germline cells from bovine tissues

1981 • 66 citations

Physical studies on synthetic DANs containing 5-methylcytosine

1974 • 65 citations

Complete DNA methylation does not prevent polyoma and simian virus 40 virus early gene expression.

1983 • 63 citations

The structure of the thymidine kinase gene promoter: Nuclease hypersensitivity correlates with expression

1982 • 63 citations

The level of expression of the rat growth hormone gene in liver tumor cells is at least eight orders of magnitude less than that in anterior pituitary cells.

1983 • 62 citations

Is hypomethylation linked to activation of δ-crystallin genes during lens development?

1983 • 53 citations

Transcription in oocytes of highly methylated rDNA from Xenopus laevis sperm

1983 • 53 citations

Phenotypic Switching in Cells Transformed with the Herpes Simplex Virus Thymidine Kinase Gene

1982 • 52 citations

Effect of DNA Methylation on Gene Expression

1983 • 39 citations

Tissue specificity and organisation of CpG methylation in calf satellite DNA I

1982 • 26 citations

DNA Methylation Patterns Associated with Asparagine Synthetase Expression in Asparagine-Overproducing and -Auxotrophic Cells

1989 • 25 citations

Deleted Work

1955 • 0 citations