Extracellular Glucose Concentration Alters Functional Activity of the Intestinal Oligopeptide Transporter (PepT-1) in Caco-2 Cells

Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

1989 • 2,127 citations

Caco-2 monolayers in experimental and theoretical predictions of drug transport1PII of original article: S0169-409X(96)00415-2. The article was originally published in Advanced Drug Delivery Reviews 22 (1996) 67–84.1

2001 • 1,479 citations

Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells

2000 • 533 citations

Human Intestinal H+/Peptide Cotransporter

1995 • 495 citations

The oligopeptide transporter (Pept-1) in human intestine: Biology and function

1997 • 337 citations

Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose

2000 • 312 citations

Transport of Valganciclovir, a Ganciclovir Prodrug, via Peptide Transporters PEPT1 and PEPT2

2000 • 304 citations

Peptide Transporters in the Intestine and the Kidney

1996 • 297 citations

Valacyclovir: A Substrate for the Intestinal and Renal Peptide Transporters PEPT1 and PEPT2

1998 • 294 citations

Targeted prodrug design to optimize drug delivery

2000 • 267 citations

Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies

1997 • 226 citations

PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine

2001 • 209 citations

Hormonal regulation of oligopeptide transporter Pept-1 in a human intestinal cell line

1999 • 161 citations

Glycation of amino groups in protein. Studies on the specificity of modification of RNase by glucose.

1985 • 157 citations

Expression and protein kinase C-dependent regulation of peptide/H+ co-transport system in the Caco-2 human colon carcinoma cell line

1994 • 144 citations

Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H(+)-coupled carriers at both apical and basal membranes.

1993 • 136 citations

New and better protocols for a short-term Caco-2 cell culture system

2002 • 126 citations

Membrane transporters

2000 • 124 citations

Sustained hyperglycemia in vitro down‐regulates the GLUT1 glucose transport system of cultured human term placental trophoblast: a mechanism to protect fetal development?¹

1998 • 107 citations

The mRNA of L-Type Calcium Channel Elevated in Colon Cancer

2000 • 106 citations

A Peptide Prodrug Approach for Improving Bisphosphonate Oral Absorption

2000 • 102 citations

Functional characteristics of basolateral peptide transporter in the human intestinal cell line Caco-2

1999 • 102 citations

Functional Roles of Histidine and Tyrosine Residues in the H+-Peptide Transporter PepT1

2000 • 97 citations

Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line

2001 • 92 citations

Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells

2002 • 71 citations

Presence of inducible nitric oxide synthase, nitrotyrosine, CD68, and CD14 in the small intestine in celiac disease.

1997 • 66 citations

Downregulation of the human taurine transporter by glucose in cultured retinal pigment epithelial cells

1999 • 65 citations

Molecular Identification of a Role for Tyrosine 167 in the Function of the Human Intestinal Proton- Coupled Dipeptide Transporter (hPepT1)

1998 • 64 citations

Down-regulation of blood-brain glucose transport in the hyperglycemic nonobese diabetic mouse

1995 • 59 citations

Inhibition of the H+/Peptide Cotransporter in the Human Intestinal Cell Line Caco-2 by Cyclic AMP

1996 • 49 citations

Noncompetitive inhibition of cephradine uptake by enalapril in rabbit intestinal brush-border membrane vesicles: an enalapril specific inhibitory binding site on the peptide carrier.

1994 • 27 citations

Involvement of thiol groups in the function of the dipeptide/proton cotransport system in rabbit renal brush-border membrane vesicles

1989 • 18 citations

Chemical Modifications of Melatonin Receptors in Chicken Brain

1994 • 6 citations