A Peptide Prodrug Approach for Improving Bisphosphonate Oral Absorption

Effect of Oral Alendronate on Bone Mineral Density and the Incidence of Fractures in Postmenopausal Osteoporosis

1995 • 2,293 citations

The Role of Phosphonates in Living Systems

2018 • 536 citations

Comparison between permeability coefficients in rat and human jejunum.

1996 • 421 citations

The oligopeptide transporter (Pept-1) in human intestine: Biology and function

1997 • 337 citations

Bisphosphonates: Preclinical Aspects and Use in Osteoporosis

1997 • 228 citations

Physiological disposition of alendronate, a potent anti-osteolytic bisphosphonate, in laboratory animals.

1991 • 161 citations

Metabolism of disodium ethane-1-hydroxy-1,1-diphosphonate (disodium etidronate) in the rat, rabbit, dog and monkey

1972 • 124 citations

ABSORPTION OF ORAL DIPHOSPHONATE IN NORMAL SUBJECTS

1986 • 119 citations

Passive and carrier-mediated intestinal absorption components of two angiotensin converting enzyme (ACE) inhibitor prodrugs in rats: enalapril and fosinopril.

1989 • 113 citations

In vitro permeability through caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system.

1996 • 112 citations

Effects of dose, sex, and age on the disposition of alendronate, a potent antiosteolytic bisphosphonate, in rats.

1992 • 96 citations

Molecular mechanism for the relative binding affinity to the intestinal peptide carrier. Comparison of three ACE-inhibitors: enalapril, enalaprilat, and lisinopril

1995 • 95 citations

Use of bisphosphonates in cancer patients

1996 • 93 citations

Use of the peptide carrier system to improve the intestinal absorption of L-alpha-methyldopa: carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa.

1989 • 89 citations

Development of a new in vitro model for studying implantable polyurethane calcification

1991 • 85 citations

Effect of Oral Alendronate on Bone Mineral Density and the Incidence of Fractures in Postmenopausal Osteoporosis

1996 • 83 citations

Alendronate

1997 • 81 citations

Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and β-lactam antibiotics

1990 • 79 citations

Membrane Transporters as Drug Targets

1999 • 79 citations

On the Absorption of Alendronate in Rats

1994 • 75 citations

Degradation Kinetics and Mechanism of Aminocephalosporins in Aqueous Solution: Cefadroxil

1981 • 75 citations

Drug Transport and Targeting

2002 • 60 citations

Utilization of Peptide Carrier System To Improve Intestinal Absorption: Targeting Prolidase as a Prodrug-Converting Enzyme

1992 • 54 citations

Membrane permeability parameters for some amino acids and β-lactam antibiotics: Application of the boundary layer approach

1988 • 54 citations

Pharmacokinetic evaluation of pamidronate after oral administration: A study on dose proportionality, absolute bioavailability, and effect of repeated administration

1993 • 48 citations

Pharmacokinetics of the osteotropic diphosphonate 3-amino-1-hydroxypropane-1,1-diphosphonic acid in mammals.

1987 • 43 citations

Anticalcification and antiresorption effects of bisacylphosphonates

1995 • 43 citations

Bisacylphosphonates inhibit hydroxyapatite formation and dissolution in vitro and dystrophic calcification in vivo.

1992 • 43 citations

Bisphosphonate Prodrugs: Synthesis and in Vitro Evaluation of Novel Clodronic Acid Dianhydrides as Bioreversible Prodrugs of Clodronate

1999 • 39 citations

Sodium EDTA enhances intestinal absorption of two bisphosphonates

1991 • 36 citations

Bisphosphonates and tetracycline: experimental models for their evaluation in calcium-related disorders.

1998 • 35 citations

Rat jejunal permeability and metabolism of mu-selective tetrapeptides in gastrointestinal fluids from humans and rats.

1997 • 32 citations

Mode of administration-dependent pharmacokinetics of bisphosphonates and bioavailability determination

2001 • 28 citations

Alendronate treatment for osteoporosis: A review of the clinical evidence

1996 • 28 citations

Animal Models of Human Related Calcium Metabolic Disorders

1995 • 27 citations

Intestinal absorption mechanism of amphoteric β-lactam antibiotics II: Michaelis—menten kinetics of cyclacillin absorption and its pharmacokinetic analysis in rats

1981 • 27 citations

In Vitro and In Vivo Anticalcification Effects of Novel Bishydroxyiminophosphonates

1992 • 21 citations

Bisphosphonates Spearhead New Approach to Treating Bone Metastases

1997 • 9 citations