Inhibition of heme synthesis induces apoptosis in human erythroid progenitor cells

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Basic Methods in Molecular Biology

1986 • 3,284 citations

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture

1977 • 2,134 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Sedimentation characteristics of rapidly labelled RNA from HeLa cells

1962 • 1,033 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells

1990 • 837 citations

Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours.

1983 • 436 citations

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

1993 • 380 citations

Purification of human erythroid colony-forming units and demonstration of specific binding of erythropoietin.

1987 • 225 citations

Human colony-forming units-erythroid do not require accessory cells, but do require direct interaction with insulin-like growth factor I and/or insulin for erythroid development.

1989 • 204 citations

Maintenance by erythropoietin of viability and maturation of murine erythroid precursor cells

1988 • 198 citations

Distinct roles of erythropoietin, insulin-like growth factor I, and stem cell factor in the development of erythroid progenitor cells.

1994 • 181 citations

Apoptosis of human erythroid colony‐forming cells is decreased by stem cell factor and insulin‐like growth factor I as well as erythropoietin

1993 • 162 citations

Succinylacetone, a potent inhibitor of heme biosynthesis: Effect on cell growth, heme content and δ-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells

1979 • 151 citations

Accelerated programmed cell death (apoptosis) in erythroid precursors of patients with severe beta-thalassemia (Cooley's anemia) [see comments]

1993 • 142 citations

Apoptosis: Final control point in cell biology

1992 • 112 citations

Mutated recombinant human heavy-chain ferritins and myelosuppression in vitro and in vivo: a link between ferritin ferroxidase activity and biological function.

1991 • 80 citations

Activation of apoptosis associated with enforced myc expression in myeloid progenitor cells is dominant to the suppression of apoptosis by interleukin-3 or erythropoietin

1993 • 70 citations

The influence of purified recombinant human heavy-subunit and light- subunit ferritins on colony formation in vitro by granulocyte- macrophage and erythroid progenitor cells

1986 • 69 citations

Control of erythroid differentiation: Possible role of the transferrin cycle

1986 • 46 citations

Ferrokinetics and Erythropoiesis in Man: Red‐Cell Production and Destruction in Normal and Anaemic Subjects

1977 • 43 citations

Estimation of Ferrokinetic Parameters by a Mathematical Model in Patients with Primary Acquired Sideroblastic Anaemia

1978 • 42 citations

c-myc is an erythropoietin early response gene in normal erythroid cells: evidence for a protein kinase C-mediated signal

1992 • 34 citations

Pyridoxine-Responsive Sideroblastic Anemia Due to Antituberculous Drugs

1967 • 24 citations

Erythroblast transferrin receptors and transferrin kinetics in iron deficiency and various anemias

1987 • 24 citations

Haem Biosynthesis in Refractory Sideroblastic Anaemia Associated with the Preleukaemic Syndrome

1981 • 22 citations

H-ferritin: a regulatory cytokine that down-modulates cell proliferation.

1992 • 20 citations

Enzymatic Defects of Heme Synthesis In Thalassemia*

1964 • 19 citations

IN VITRO HEME SYNTHESIS BY HUMAN BLOOD: ABNORMAL HEME SYNTHESIS IN THALASSEMIA MAJOR.

1964 • 17 citations

Inhibition of heme synthesis in bone marrow cells by succinylacetone: Effect on globin synthesis

1983 • 16 citations

Therapeutic effect of heme arginate in myelodysplastic syndromes

1992 • 15 citations

Abnormalities of Heme and Pyrrole Metabolism in Thalassemia

1964 • 15 citations

Inhibition of heme synthesis decreases transferrin receptor expression in mouse erythroleukemia cells

1992 • 15 citations

Binding and suppressive activity of human recombinant ferritins on erythroid cells

1992 • 14 citations

Possible mechanism of ineffective erythropoiesis by an altered transferrin receptor cycle in erythroleukemia

1988 • 7 citations

Pyridoxine-responsive sideroblastic anemia due to antituberculous drugs

1967 • 5 citations

Intracellular heme coordinately modulates globin chain synthesis, transferrin receptor number, and ferritin content in differentiating Friend erythroleukemia cells

1991 • 2 citations