Osmotic regulation of the heat shock response in H4IIE rat hepatoma cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

AP-1 function and regulation

1997 • 2,833 citations

Functional Significance of Cell Volume Regulatory Mechanisms

1998 • 1,871 citations

Heat shock, stress proteins, chaperones, and proteotoxicity

1991 • 1,069 citations

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival

1998 • 742 citations

Protein kinase cascades activated by stress and inflammatory cytokines

1996 • 722 citations

Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase

1992 • 647 citations

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

1996 • 457 citations

Cellular hydration state: an important determinant of protein catabolism in health and disease

1993 • 434 citations

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

1993 • 348 citations

An emerging family of dual specificity MAP kinase phosphatases

1995 • 256 citations

Immediate early gene and HSP70 expression in hyperosmotic stress in MDCK cells

1991 • 223 citations

The role of heat-shock proteins in thermotolerance

1993 • 200 citations

Cell volume and hormone action

1992 • 129 citations

Activation of extracellular signal-regulated kinases Erk-1 and Erk-2 by cell swelling in H4IIE hepatoma cells

1995 • 129 citations

Regulation of taurocholate excretion by a hypo-osmolarity-activated signal transduction pathway in rat liver

1996 • 116 citations

Protein Kinase Signaling Pathway Triggered by Cell Swelling and Involved in the Activation of Glycogen Synthase and Acetyl-CoA Carboxylase in Isolated Rat Hepatocytes

1996 • 110 citations

Induction of gene expression by heat shock versus osmotic stress

1994 • 104 citations

Cytoprotection by the osmolytes betaine and taurine in ischemia- reoxygenation injury in the perfused rat liver

1997 • 81 citations

Effect of anisotonic cell‐volume modulation on glutathione‐S‐conjugate release, t‐butylhydroperoxide metabolism and the pentose‐phosphate shunt in perfused rat liver

1992 • 70 citations

Arsenite inhibits two steps in the ubiquitin-dependent proteolytic pathway

1989 • 66 citations

The heat-shock transcription factor HSF1 is rapidly activated by either hyper- or hypo-osmotic stress in mammalian cells

1997 • 63 citations

Hyperosmotic Induction of the Mitogen-Activated Protein Kinase Phosphatase MKP-1 in H4IIE Rat Hepatoma Cells

1998 • 62 citations

Osmotic regulation of the heat shock response in primary rat hepatocytes

1998 • 58 citations

Effect of betaine on HSP70 expression and cell survival during adaptation to osmotic stress

1993 • 51 citations

Increase of c‐jun mRNA upon hypo‐osmotic cell swelling of rat hepatoma cells

1994 • 47 citations

Induction of molecular chaperones by hyperosmotic stress in mouse inner medullary collecting duct cells

1997 • 46 citations

Cell swelling increases bile flow and taurocholate excretion into bile in isolated perfused rat liver

1992 • 44 citations

The two activation domains of the CCAAT-binding factor CBF interact with the dTAFII110 component of the Drosophila TFIID complex

1998 • 43 citations

Transient Acquired Thermotolerance in Drosophila, Correlated with Rapid Degradation of Hsp70 During Recovery

1995 • 41 citations

In vivo and in vitro osmotic regulation of HSP-70 and prostaglandin synthase gene expression in kidney cells

1995 • 40 citations

Transient Acquired Thermotolerance in Drosophila, Correlated with Rapid Degradation of Hsp70 During Recovery

1995 • 35 citations

The Contrasting Role of Calcium Influx in Secretion Induced by Cell Swelling Can Differentiate Normal and Tumor-Derived Rat Pituitary Cells*

1991 • 28 citations

Osmotic Regulation of MAP-Kinase Activities and Gene Expression in H4IIE Rat Hepatoma Cells

1998 • 27 citations

The phosphorylation state of MAP‐kinases modulates the cytotoxic response of smooth muscle cells to hydrogen peroxide

1996 • 25 citations

Cytoprotection by the osmolytes ?ine and taurine in ischemia- reoxygenation injury in the perfused rat liver

1997 • 12 citations

Hyperthermia in cancer research: current status.

1996 • 8 citations