Exercise Capacity in Chronic Obstructive Pulmonary Disease: Mechanisms of Limitation

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

2001 • 6,099 citations

ATS/ACCP Statement on Cardiopulmonary Exercise Testing

2003 • 2,603 citations

Reflex cardiovascular and respiratory responses originating in exercising muscle

1972 • 1,096 citations

Dynamic Hyperinflation and Exercise Intolerance in Chronic Obstructive Pulmonary Disease

2001 • 1,034 citations

Peripheral muscle weakness contributes to exercise limitation in COPD.

1996 • 1,011 citations

Changes in muscle contractile properties and neural control during human muscular fatigue

1984 • 992 citations

Reductions in Exercise Lactic Acidosis and Ventilation as a Result of Exercise Training in Patients with Obstructive Lung Disease

1991 • 909 citations

Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD

2004 • 853 citations

Fatigue of long duration in human skeletal muscle after exercise.

1977 • 777 citations

Peripheral Muscle Weakness in Patients with Chronic Obstructive Pulmonary Disease

1998 • 772 citations

Respiratory muscle work compromises leg blood flow during maximal exercise

1997 • 673 citations

Oxidative capacity of the skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPD.

1996 • 578 citations

Muscle strength, symptom intensity, and exercise capacity in patients with cardiorespiratory disorders.

1995 • 574 citations

Analysis of the Factors Related to Mortality in Chronic Obstructive Pulmonary Disease

2003 • 570 citations

Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause?

2002 • 561 citations

Exertional Breathlessness in Patients with Chronic Airflow Limitation: The Role of Lung Hyperinflation

1993 • 549 citations

Exercise Capacity and Ventilatory, Circulatory, and Symptom Limitation in Patients with Chronic Airflow Limitation

1992 • 538 citations

Spirometric Correlates of Improvement in Exercise Performance after Anticholinergic Therapy in Chronic Obstructive Pulmonary Disease

1999 • 491 citations

Invited Review: Redox modulation of skeletal muscle contraction: what we know and what we don't

2001 • 449 citations

Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise

1998 • 446 citations

Predictors of Mortality in Patients with Emphysema and Severe Airflow Obstruction

2006 • 434 citations

Qualitative aspects of exertional breathlessness in chronic airflow limitation: pathophysiologic mechanisms.

1997 • 428 citations

Energy supply and muscle fatigue in humans

1998 • 415 citations

Cellular mechanisms of fatigue in skeletal muscle

1991 • 412 citations

Hyperinflation, Dyspnea, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease

2006 • 384 citations

Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease

2004 • 363 citations

Blood and muscle pH after maximal exercise in man

1972 • 334 citations

Pulmonary mechanics during exercise in subjects with chronic airflow obstruction

1980 • 319 citations

Respiratory and Limb Muscle Weakness Induced by Tumor Necrosis Factor-α

2002 • 315 citations

Improvements in Symptom-Limited Exercise Performance Over 8 h With Once-Daily Tiotropium in Patients With COPD

2005 • 306 citations

Effects of Endurance Training on Skeletal Muscle Bioenergetics in Chronic Obstructive Pulmonary Disease

1999 • 265 citations

Contractile Leg Fatigue after Cycle Exercise

2003 • 253 citations

Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD

2006 • 240 citations

Ventilatory mechanics and expiratory flow limitation during exercise in patients with obstructive lung disease

1971 • 240 citations

Descriptors of breathlessness in cardiorespiratory diseases.

1996 • 231 citations

Peripheral muscle endurance and the oxidative profile of the quadriceps in patients with COPD

2004 • 218 citations

Effect of inspiratory muscle work on peripheral fatigue of locomotor muscles in healthy humans

2005 • 211 citations

Symptoms and Quadriceps Fatigability after Walking and Cycling in Chronic Obstructive Pulmonary Disease

2003 • 211 citations

Quadriceps strength and fatigue assessed by magnetic stimulation of the femoral nerve in man

1996 • 208 citations

Ventilatory and metabolic adaptations to walking and cycling in patients with COPD

2000 • 198 citations

Chest wall mechanics during exercise in patients with severe chronic air-flow obstruction.

1984 • 195 citations

Effect of mild-to-moderate airflow limitation on exercise capacity

1991 • 191 citations

Metabolic and hemodynamic responses of lower limb during exercise in patients with COPD

1998 • 185 citations

The effect of acid–base balance on fatigue of skeletal muscle

1985 • 174 citations

Prediction of amorphous phase stability in the metal–silicon systems

2001 • 173 citations

Cachectin/tumor necrosis factor mediates changes of skeletal muscle plasma membrane potential.

1986 • 172 citations

Metabolic Factors in Fatigue

2006 • 158 citations

Evidence of Skeletal Muscle Metabolic Reserve During Whole Body Exercise in Patients with Chronic Obstructive Pulmonary Disease

1999 • 158 citations

Muscle fatigue and lactic acid accumulation.

1986 • 140 citations

Phosphocreatine content in single fibers of human muscle after sustained submaximal exercise

1997 • 139 citations

EXERCISE LIMITATION AND CLINICAL EXERCISE TESTING IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

1994 • 139 citations

Contractile Fatigue, Muscle Morphometry, and Blood Lactate in Chronic Obstructive Pulmonary Disease

2005 • 135 citations

Walking versus Cycling

2005 • 133 citations

Symptom Intensity and Subjective Limitation to Exercise in Patients With Cardiorespiratory Disorders

1996 • 128 citations

Quadriceps Fatigue after Cycle Exercise in Patients with Chronic Obstructive Pulmonary Disease

2000 • 127 citations

Recent advances in the understanding of skeletal muscle fatigue

2002 • 126 citations

Effects of muscle fatigue on mechanically sensitive afferents of slow conduction velocity in the cat triceps surae

1991 • 112 citations

Dyspnea and Leg Effort during Incremental Cycle Ergometry

1992 • 111 citations

The ventilatory capacity of patients with chronic airways obstruction.

1969 • 108 citations

Inspiratory muscles during exercise: a problem of supply and demand

1988 • 102 citations

Limitation of lower limbV˙<scp>o</scp>₂during cycling exercise in COPD patients

2001 • 99 citations

Quadriceps muscle endurance in patients with chronic obstructive pulmonary disease

2004 • 97 citations

Exercise training during rehabilitation of patients with COPD: A current perspective

2003 • 94 citations

Quadriceps Fatigue After Cycle Exercise in Patients With COPD Compared With Healthy Control Subjects

2003 • 88 citations

Effects of oxygen on lower limb blood flow and O2 uptake during exercise in COPD

2001 • 87 citations

Small Airway Pathology is Related to Increased Closing Capacity and Abnormal Slope of Phase III in Excised Human Lungs^1–3

1980 • 86 citations

The role of spinal cord transmission in the ventilatory response to exercise in man.

1984 • 65 citations

Effects of acute hypoxemia on force and surface EMG during sustained handgrip

2001 • 62 citations

Dynamic Hyperinflation: Is It Worth Measuring?

2006 • 62 citations

Flow-volume Curves and Breathing Patterns during Exercise in Patients with Obstructive Lung Disease

1970 • 60 citations

L (+)-lactate does not affect twitch and tetanic responses in mechanically skinned mammalian muscle fibres

2001 • 60 citations

Pathologic Changes and Contractile Properties of the Diaphragm in Corticosteroid Myopathy in Hamsters: Comparison to Peripheral Muscle

1989 • 59 citations

Relationship of skeletal muscle metaboreceptors in the upper and lower limbs with the respiratory control in patients with heart failure

2001 • 47 citations

Assessment of muscle fatigue during exercise in chronic obstructive pulmonary disease

2006 • 40 citations

Electrophysiologic changes during exercise testing in patients with chronic obstructive pulmonary disease

2002 • 40 citations

Blood flow distribution, lymph flow, villus tissue osmolality and fluid and electrolyte transport after exposing the cat small intestine to sodium deoxycholate

1986 • 38 citations

Effects of Chronic Hypoxemia on the Afferent Nerve Activities from Skeletal Muscle

2001 • 35 citations

MECHANISMS OF EXERTIONAL DYSPNEA

1994 • 32 citations

Effect of acute hyperoxia during exercise on quadriceps electrical activity in active COPD patients

2004 • 29 citations

Endurance training improves skeletal muscle electrical activity in active COPD patients

2003 • 27 citations

Muscle fatigue: mechanisms and regulation

2000 • 22 citations

Exercise capacity and breathing mechanics in patients with airflow limitation

1992 • 18 citations

CLINICAL EXERCISE TESTING IN CHRONIC AIRFLOW LIMITATION

1996 • 17 citations

Involvement of membrane excitation failure in fatigue induced by intermittent submaximal voluntary contraction of the first dorsal interosseous muscle.

1993 • 12 citations

Physiological basis of dyspnoea

2005 • 3 citations

Pulmonary rehabilitation

2004 • 2 citations