SAC1-like Domains of Yeast SAC1,INP52, and INP53 and of Human Synaptojanin Encode Polyphosphoinositide Phosphatases

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

Phosphoinositides as Regulators in Membrane Traffic

1996 • 717 citations

Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body

1998 • 652 citations

A presynaptic inositol-5-phosphatase

1996 • 573 citations

Phosphoinositide kinases

1996 • 529 citations

Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis

1997 • 460 citations

SopB, a protein required for virulence of Salmonella dublin , is an inositol phosphate phosphatase

1998 • 436 citations

Fab1p Is Essential for PtdIns(3)P 5-Kinase Activity and the Maintenance of Vacuolar Size and Membrane Homeostasis

1998 • 416 citations

REGULATION OF EUKARYOTIC PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C AND PHOSPHOLIPASE D

1997 • 390 citations

Structure and function of theprotein tyrosine phosphatases

1996 • 339 citations

Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes

1995 • 293 citations

Suppressors of yeast actin mutations.

1989 • 286 citations

Essential role for diacylglycerol in protein transport from the yeast Golgi complex

1997 • 257 citations

Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function.

1989 • 228 citations

The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae

1998 • 222 citations

Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects

1998 • 161 citations

Phosphoinositide signaling and turnover: PtdIns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities

1998 • 148 citations

Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts

1997 • 141 citations

A Phosphatidylinositol 4-Kinase Pleckstrin Homology Domain That Binds Phosphatidylinositol 4-Monophosphate

1998 • 140 citations

The diversity and possible functions of the inositol polyphosphate 5-phosphatases

1998 • 138 citations

Identification and Characterization of an Essential Family of Inositol Polyphosphate 5-Phosphatases (INP51, INP52 and INP53 Gene Products) in the Yeast Saccharomyces cerevisiae

1998 • 121 citations

Synaptojanin Inhibition of Phospholipase D Activity by Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate

1997 • 120 citations

Phospholipid-binding protein domains

1998 • 116 citations

PIPkins1We introduce here the abbreviation PIPkin (an abbreviation we have used in our lab for years) for cogent reasons. Previously, PtdIns4P 5-kinase was the favoured abbreviation, but in view of the extensive revision and uncertainty as to substrates and products that we discuss in this review, only PtdInsP kinase would now suffice. Moreover, we have recently recorded evidence that type II PIPkin is subject to multiple phosphorylations by protein kinases [1]. As we progress in our …

1998 • 110 citations

Novel Genes Involved in Endosomal Traffic in Yeast Revealed by Suppression of a Targeting-defective Plasma Membrane ATPase Mutant

1997 • 103 citations

INP51, a Yeast Inositol Polyphosphate 5-Phosphatase Required for Phosphatidylinositol 4,5-Bisphosphate Homeostasis and Whose Absence Confers a Cold-resistant Phenotype

1998 • 101 citations

Phosphoinositides as spatial regulators of membrane traffic

1997 • 100 citations

The phosphatidylinositol 4-phosphate 5-kinase family

1996 • 97 citations

Disruption of three phosphatidylinositol-polyphosphate 5-phosphatase genes from Saccharomyces cerevisiae results in pleiotropic abnormalities of vacuole morphology, cell shape, and osmohomeostasis.

1997 • 85 citations

Epidermal growth factor increases the labeling of phosphatidylinositol 3,4-bisphosphate in MA-10 Leydig tumor cells.

1990 • 79 citations

Sac1p mediates the adenosine triphosphate transport into yeast endoplasmic reticulum that is required for protein translocation.

1995 • 69 citations

Regulation of second messengers by the inositol polyphosphate 5-phosphatases

1996 • 59 citations

Inositols do it all.

1996 • 55 citations

Inositol trisphosphate metabolism in Saccharomyces cerevisiae: identification, purification and properties of inositol 1,4,5-trisphosphate 6-kinase

1994 • 31 citations

Purification and characterization of a polyphosphoinositide phosphatase from rat brain.

1994 • 16 citations